Association between orthostatic hypotension and cardiovascular risk, cerebrovascular risk, cognitive decline and falls as well as overall mortality: A systematic review and meta-analysis

Journal of Hypertension

Volumn 32, Issue 8, 2014, Pages 1562-1571

  Angelousi, Anna ^a   Girerd, Nicolas ^b   Benetos, Athanase ^a   Frimat, Luc ^a   Gautier, Sylvie ^a   Weryha, Georges ^a   Boivin, Jean Marc ^b  

^a CHU NANCY BRABOIS   (France)

^b INSERM   (France)

Author keywords

cardiovascular risk; cognitive decline; coronary disease; dementia; falls; mortality; orthostatic hypotension; strokes; white matter lesions hyperintensities

Indexed keywords

CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; COMORBIDITY; DEMENTIA; FALLING; HEART ARRHYTHMIA; HEART FAILURE; HUMAN; META ANALYSIS; MORTALITY; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW; WHITE MATTER LESION; CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; COMPLICATION; PROSPECTIVE STUDY; RISK;

ACCIDENTAL FALLS; CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; HUMANS; HYPOTENSION, ORTHOSTATIC; PROSPECTIVE STUDIES; RISK;

EID: 84904055176     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000000235     Document Type: Review

References (60)

1. Feldstein C, Weder AB. Orthostatic hypotension: A common, serious and underrecognized problem in hospitalized patients. J Am Soc Hypertens 2012; 6:27-39.
2. Valbusa F, Labat C, Salvi P, Vivian ME, Hanon O, Benetos A, on behalf of the PARTAGE investigators. Orthostatic hypotension in very old individuals living in nursing homes: The PARTAGE study. J Hypertens 2012; 30:53-60.
3. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 1996; 46:1470.
4. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci 2011; 26:46-48.
5. Fedorowski A, Franceschini N, Brody J, Liu C, Verwoert GC, Boerwinkle E, et al. Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium. Eur Heart J 2012; 33:2331-2341.
6. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and metaanalyses of studies that evaluate healthcare interventions: explanation and elaboration. PLoS Med 2009; 21:e1000100.
7. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ, GRADE Working Group. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924-926. (Pubitemid 351632017)
8. Jones CD, Loehr L, Franceschini N, Rosamond WD, Chang PP, Shahar E, et al. Orthostatic hypotension as a risk factor for incident heart failure: The atherosclerosis risk in communities study. Hypertension 2012; 59:913-918.
9. Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM, Melander O. Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project). Eur Heart J 2010; 31:85-91.
10. Fagard RH, De Cort P. Orthostatic hypotension is a more robust predictor of cardiovascular events than nighttime reverse dipping in elderly. Hypertension 2010; 56:56-61.
11. Verwoert GC, Mattace-Raso FU, Hofman A, Heeringa J, Stricker BH, Breteler MM, et al. Orthostatic hypotension and risk of cardiovascular disease in elderly people: The Rotterdam study. J Am Geriatr Soc 2008; 56:1816-1820.
12. Rose KM, Eigenbrodt ML, Biga RL, Couper DJ, Light KC, Sharrett AR, et al. Orthostatic hypotension predicts mortality in middle-aged adults: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 2006; 15:630-636. (Pubitemid 44252304)
13. Luukinen H, Koski K, Laippala P, Airaksinen KE. Orthostatic hypotension and the risk of myocardial infarction in the home-dwelling elderly. J Intern Med 2004; 255:486-493. (Pubitemid 38446362)
14. Sarasin FP, Louis-Simonet M, Carballo D, Slama S, Junod AF, Unger PF. Prevalence of orthostatic hypotension among patients presenting with syncope in the ED. Am J Emerg Med 2002; 20:497-501. (Pubitemid 35168151)
15. Rose KM, Tyroler HA, Nardo CJ, Arnett DK, Light KC, Rosamond W, et al. Orthostatic hypotension and the incidence of coronary heart disease: The Atherosclerosis Risk in Communities study. Am J Hypertens 2000; 13:571-578. (Pubitemid 30459866)
16. Weiss A, Beloosesky Y, Kornowski R, Yalov A, Grinblat J, Grossman E. Influence of orthostatic hypotension on mortality among patients discharged from an acute geriatric ward. J Gen Intern Med 2006; 21:602-606. (Pubitemid 43801489)
17. Luukinen H, Airaksinen KE. Orthostatic hypotension predicts vascular death in older diabetic patients. Diabetes Res Clin Pract 2005; 67:163-166. (Pubitemid 40093026)
18. Fisher AA, Davis MW, Srikusalanukul W, Budge MM. Postprandial hypotension predicts all-cause mortality in older, low-level care residents. J Am Geriatr Soc 2005; 53:1313-1320. (Pubitemid 41602476)
19. Masaki KH, Schatz IJ, Burchfiel CM, Sharp DS, Chiu D, Foley D, Curb JD. Orthostatic hypotension predicts mortality in elderly men: The Honolulu Heart Program. Circulation 1998; 98:2290-2295. (Pubitemid 28533848)
20. Tilvis RS, Hakala SM, Valvanne J, Erkinjuntti T. Postural hypotension and dizziness in a general aged population: A four-year follow-up of the Helsinki Aging Study. J Am Geriatr Soc 1996; 44:809-814. (Pubitemid 26238724)
21. Passant U, Warkentin S, Gustafson L. Orthostatic hypotension and low blood pressure in organic dementia: A study of prevalence and related clinical characteristics. Int J Geriatr Psychiatry 1997; 12:395-403. (Pubitemid 27148464)
22. Yatsuya H, Folsom AR, Alonso A, Gottesman RF, Rose KM, ARIC Study Investigators. Postural changes in blood pressure and incidence of ischemic stroke subtypes: The ARIC study. Hypertension 2011; 57:167-173.
23. Yap PL, Niti M, Yap KB, Ng TP. Orthostatic hypotension, hypotension and cognitive status: early comorbid markers of primary dementia? Dement Geriatr Cogn Disord 2008; 26:239-246.
24. Kario K, Eguchi K, Hoshide S, Hoshide Y, Umeda Y, Mitsuhashi T, Shimada K. U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives: orthostatic hypertension as a new cardiovascular risk factor. J Am Coll Cardiol 2002; 40:133-141. (Pubitemid 34701388)
25. Hossain M, Ooi WL, Lipsitz LA. Intra-individual postural blood pressure variability and stroke in elderly nursing home residents. J Clin Epidemiol 2001; 54:488-494. (Pubitemid 32405292)
26. Eigenbrodt ML, Rose KM, Couper DJ, Arnett DK, Smith R, Jones D. Orthostatic hypotension as a risk factor for stroke: The Atherosclerosis Risk in Communities (ARIC) study, 1987-1996. Stroke 2000; 31:2307-2313.
27. Viramo P, Luukinen H, Koski K, Laippala P, Sulkava R, Kivelä SL. Orthostatic hypotension and cognitive decline in older people. J Am Geriatr Soc 1999; 47:600-604. (Pubitemid 29215590)
28. Gangavati A, Hajjar I, Quach L, Jones RN, Kiely DK, Gagnon P, Lipsitz LA. Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: The maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J Am Geriatr Soc 2011; 59:383-539.
29. Czarkowska H, Tutaj M, Rudzin'ska M, Motyl M, Brys M, Bukowczan S, et al. Cardiac responses to orthostatic stress deteriorate in Parkinson disease patients who begin to fall. Neurol Neurochir Pol 2010; 44:339-349.
30. Chu LW, Chi I, Chiu AY. Incidence and predictors of falls in the Chinese elderly. Ann Acad Med Singapore 2005; 34:60-72 (Pubitemid 40379974)
31. Erratum in: Ann Acad Med Singapore 2005; 34: 469.
32. Maurer MS, Cohen S, Cheng H. The degree and timing of orthostatic blood pressure changes in relation to falls in nursing home residents. J Am Med Dir Assoc 2004; 5:233-238. (Pubitemid 39089700)
33. Tromp AM, Pluijm SM, Smit JH, Deeg DJ, Bouter LM, Lips P. Fall-risk screening test: A prospective study on predictors for falls in communitydwelling elderly. J Clin Epidemiol 2001; 54:837-844. (Pubitemid 32722189)
34. Kario K, Tobin JN, Wolfson LI, Whipple R, Derby CA, Singh D, et al. Lower standing systolic blood pressure as a predictor of falls in the elderly: A community-based prospective study. J Am Coll Cardiol 2001; 38:246-252. (Pubitemid 32613858)
35. Ooi WL, Hossain M, Lipsitz LA. The association between orthostatic hypotension and recurrent falls in nursing home residents. Am J Med 2000; 108:106-111. (Pubitemid 30064420)
36. Graafmans WC, Ooms ME, Hofstee HM, Bezemer PD, Bouter LM, Lips P. Falls in the elderly: A prospective study of risk factors and risk profiles. Am J Epidemiol 1996; 143:1129-1136. (Pubitemid 26158109)
37. Higgins JP, Thompson SG. Quantifying heterogeneity in a metaanalysis. Stat Med 2002; 21:1539-1558.
38. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315:629-634. (Pubitemid 27387172)
39. Fedorowski A, Hedblad B, Engström G, Gustav Smith J, Melander O. Orthostatic hypotension and long-term incidence of atrial fibrillation: The Malmö Preventive Project. J Intern Med 2010; 268:383-389.
40. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. J Neurol Sci 1996; 144:218-219.
41. Wieling W, Schatz IJ. The consensus statement on the definition of orthostatic hypotension: A revisit after 13 years. J Hypertens 2009; 27:935-938.
42. Romero-Ortuno R, Cogan L, Foran T, Kenny RA, Fan CW. Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people. J Am Geriatr Soc 2011; 59:655-665.
43. Braam EA, Verbakel D, Adiyaman A, Thien T. Orthostatic hypotension: revision of the definition is needed. J Hypertens 2009; 27:2119-2220.
44. Fedorowski A, Ostling G, Persson M, Struck J, Engström G, Nilsson PM, et al. Orthostatic blood pressure response, carotid intima-media thickness, and plasma fibrinogen in older nondiabetic adults. J Hypertens 2012; 30:522-529.
45. Tang A, Eng JJ, Krassioukov A. Application of the Sit-Up Test for orthostatic hypotension in individuals with stroke. Auton Neurosci 2012; 168:82-87.
46. Fan XH, Wang Y, Sun K, Zhang W, Wang H, Wu H, et al. Disorders of orthostatic blood pressure response are associated with cardiovascular disease and target organ damage in hypertensive patients. Am J Hypertens 2010; 23:829-837.
47. Euser SM, van Bemmel T, Schram MT, Gussekloo J, Hofman A, Westendorp RG, Breteler MM. The effect of age on the association between blood pressure and cognitive function later in life. J Am Geriatr Soc 2009; 57:1232-1237.
48. van Beek AH, Claassen JA, Rikkert MG, Jansen RW. Cerebral autoregulation: An overview of current concepts and methodology with special focus on the elderly. J Cereb Blood Flow Metab 2008; 28:1071-1085. (Pubitemid 351733344)
49. Elmstáhl S, Rosén I. Postural hypotension and EEG variables predict cognitive decline: results from a 5-year follow-up of healthy elderly women. Dement Geriatr Cogn Disord 1997; 8:180-187.
50. Schoon Y, Lagro J, Verhoeven Y, Rikkert MO, Claassen J. Hypotensive syndromes are not associated with cognitive impairment in geriatric patients. Am J Alzheimer Dis Other Demen 2013; 28:47-53.
51. Shaw FE, Bond J, Richardson DA, Dawson P, Steen IN, McKeith IG, Kenny RA. Multifactorial intervention after a fall in older people with cognitive impairment and dementia presenting to the accident and emergency department: randomised controlled trial. BMJ 2003; 326:73
52. Erratum in: BMJ 2003; 326:699.
53. Gates S, Fisher JD, Cooke MW, Carter YH, Lamb SE. Multifactorial assessment and targeted intervention for preventing falls and injuries among older people in community and emergency care settings: systematic review and meta-analysis. BMJ 2008; 336:130-133. (Pubitemid 351211964)
54. Lamb SE, Jørstad-Stein EC, Hauer K, Becker C, Prevention of Falls Network Europe and Outcomes Consensus Group. Development of a common outcome data set for fall injury prevention trials: The Prevention of Falls Network Europe consensus. J Am Geriatr Soc 2005; 53:1618-1622. (Pubitemid 41602457)
55. Low PA, Singer W. Management of neurogenic orthostatic hypotension: An update. Lancet Neurol 2008; 7:451-458. (Pubitemid 351508480)
56. Coppini DV, Bowtell PA, Weng C, Young PJ, Sönksen PH. Showing neuropathy is related to increased mortality in diabetic patients: A survival analysis using an accelerated failure time model. J Clin Epidemiol 2000; 53:519-523. (Pubitemid 30254349)
57. Hilsted J, Parving HH, Christensen NJ, Benn J, Galbo H. Hemodynamics in diabetic orthostatic hypotension. J Clin Invest 1981; 68:1427-1434. (Pubitemid 12194396)
58. Mattace-Raso FU, van der Cammen TJ, Knetsch AM, van den Meiracker AH, Schalekamp MA, Hofman A, Witteman JC. Arterial stiffness as the candidate underlying mechanism for postural blood pressure changes and orthostatic hypotension in older adults: The Rotterdam study. J Hypertens 2006; 24:339-344. (Pubitemid 43348247)
59. Mattace-Raso FU, van den Meiracker AH, Bos WJ, van der Cammen TJ, Westerhof BE, Elias-Smale S, et al. Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: The Rotterdam study. J Hypertens 2007; 25:1421-1426. (Pubitemid 46918829)
60. Boddaert J, Tamim H, Verny M, Belmin J. Arterial stiffness is associated with orthostatic hypotension in elderly subjects with history of falls. J Am Geriatr Soc 2004; 52:568-572. (Pubitemid 38480634)