Associations of sex steroids with bone maturation, bone mineral density, bone geometry, and body composition: A cross-sectional study in healthy male adolescents

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 7, 2014, Pages

  Vandewalle, S ^a   Taes, Y ^a   Fiers, T ^a   Toye, K ^a   Van Caenegem, E ^a   Roggen, I ^b   De Schepper, J ^a,b   Kaufman, J M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b University Hospital Brussels   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; TESTOSTERONE;

ADOLESCENT; ADULT; ANTHROPOMETRIC PARAMETERS; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BONE AGE; BONE DENSITOMETRY; BONE DENSITY; BONE MATURATION; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; CORTICAL THICKNESS (BONE); CROSS-SECTIONAL STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENDOSTEAL CIRCUMFERENCE; ESTRADIOL BLOOD LEVEL; FAT MASS; FOREARM; HUMAN; LEAN BODY WEIGHT; LEG; LIQUID CHROMATOGRAPHY; LUMBAR SPINE; MALE; NORMAL HUMAN; PERIOSTEAL CIRCUMFERENCE; PRIORITY JOURNAL; PUBERTY; QUANTITATIVE ANALYSIS; RADIUS; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL; TIBIA; TRABECULAR BONE; VOLUMETRY;

ADOLESCENT; ADOLESCENT DEVELOPMENT; BODY COMPOSITION; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; CHILD; CROSS-SECTIONAL STUDIES; GONADAL STEROID HORMONES; HEALTH; HUMANS; MALE; ORGAN SIZE; YOUNG ADULT;

EID: 84904048031     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3887     Document Type: Article

References (39)

1. Pomerant T, Tillmann V, Jürimäe J, Jürimäe T. The influence of serum ghrelin, IGF axis and testosterone on bone mineral density in boys at different stages of sexual maturity. J Bone Miner Metab. 2007;25:193-197. (Pubitemid 46643764)
2. Soyka LA, Fairfield WP, Klibanski A. Hormonal determinants and disorders of peak bone mass in children. J Clin Endocrinol Metab. 2000;85:3951-3963. (Pubitemid 32055332)
3. Finkelstein JS, Neer RM, Biller BMK, Crawford JD, Klibanski A. Osteopenia in men with a history of delayed puberty. NEngl J Med. 1992;326:600-604.
4. Gilsanz V, Chalfant J, Kalkwarf H, et al. Age at onset of puberty predicts bone mass in young adulthood. J Pediatr. 2011;158:100-105.
5. Yap F, Hogler W, Briody J. The skeletal phenotype of men with previous constitutional delay of puberty. J Clin Endocrinol Metab. 2004;89:4306-4311. (Pubitemid 39244430)
6. Riggs B, Khosla S, Melton LJ 3rd. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002;23:279-302. (Pubitemid 34651948)
7. Yilmaz D, Ersoy B, Bilgin E, Gümüser G, Onur E, Pinar ED. Bone mineral density in girls and boys at different pubertal stages: relation with gonadal steroids, bone formation markers and growth parameters. J Bone Miner Metab. 2005;23:476-482. (Pubitemid 41571115)
8. Schoenau E. From mechanostat theory to development of the "functional muscle-bone-unit." J Musculoskelet Neuronal Interact. 2005; 5:232-238. (Pubitemid 41684172)
9. Vanderschueren D, van Herck E, Nijs J. Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology. 1997;138:2301-2307. (Pubitemid 27215229)
10. Callewaert F, Venken K, Kopchick J. Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models. J Bone Miner Res. 2010; 25:617-626.
11. Smith EP, Boyd J, Frank GR, Takahashi H, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. NEngl J Med. 1994;331:1056-1061. (Pubitemid 24317698)
12. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab. 1995;80:3689-3698.
13. Carani C, Qin K, Simoni M, et al. Effect of testosterone and estradiol in amanwith aromatase deficiency. NEngl JMed. 1997;337:91-95. (Pubitemid 27284394)
14. Bilezikian JP, Morishima A, Bell J, Grumbach MM. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med. 1998;339:599-603. (Pubitemid 28385657)
15. Lorentzon M, Swanson C, Andersson N, Mellström D, Ohlsson C. Free testosterone is a positive, whereas free estradiol is a negative predictor of cortical bone size in young Swedish men: the Good study. J Bone Miner Res. 2005;20:1334-1341. (Pubitemid 41033517)
16. Lapauw B, Taes Y, Bogaert V, et al. Serum estradiol is associated with volumetric BMD and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblings. J Bone Miner Res. 2009;24:1075-1085.
17. Philippaerts RM, Matton L, Wijndaele K, Balduck A-L, De Bourdeaudhuij I, Lefevre J. Validity of a physical activity computer questionnaire in 12- to 18-year-old boys and girls. Int J Sports Med. 2006;27:131-136. (Pubitemid 43288525)
18. Verloigne M, De Bourdeaudhuij I, et al. Self-determined motivation towards physical activity in adolescents treated for obesity: an observational study. Int J Behav Nutr Phys Act. 19:2011;8:97.
19. Roelants M, Hauspie R, Hoppenbrouwers K. References for growth and pubertal development from birth to 21 years in Flanders Belgium. Ann Hum Biol. 2009;36:680-694.
20. Greulich WW, Pyle SI. Radiographic Atlas of Skeletal Development of the Hand and Wrist. Stanford, CA: Stanford University Press; 1959.
21. Schönau E, Neu CM, Rauch F, Manz F. The development of bone strength at the proximal radius during childhood and adolescence. J Clin Endocrinol Metab. 2001;86:613-618. (Pubitemid 32207468)
22. Vandewalle S, Taes Y, Van Helvoirt M, et al. Bone size and bone strength are increased in obese male adolescents. J Clin Endocrinol Metab. 2013;98:3019-3028.
23. Fiers T, Casetta B, Bernaert B, Vandersypt E, Debock M, Kaufman JM. Development of highly sensitive method for the quantification of estrone and estradiol in serum by liquid chromatography tandem mass spectrometry without derivatization. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;893-894:57-62.
24. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84:3666-3672. (Pubitemid 30645223)
25. Szulc P, Claustrat B, Munoz F, Marchand F, Delmas PD. Assessment of the role of 17β-oestradiol in bone metabolism in men: does the assay technique matter? The Minos study. Clin Endocrinol (Oxf). 2004;61:447-457. (Pubitemid 39388483)
26. Van Caenegem E, Wierckx K, Taes Y, et al. Bone mass, bone geometry and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy. J Clin Endocrinol Metab. 2012;97:2503-2511.
27. De Schepper J, Derde MP, Van den Broeck M, Piepsz A, Jonckheer MH. Normative data for lumbar spine bone mineral content in children: influence of age, height, weight and pubertal stage. J Nucl Med. 1991;32:216-220.
28. Schönau E, Neu CM, Rauch F, Manz F. Gender-specific pubertal changes in volumetric cortical bone mineral density at the proximal radius. Bone. 2002;31:110-113. (Pubitemid 34754435)
29. Neu CM, Manz F, Rauch F, Merkel A, Schönau E. Bone densities and bone size at the distal radius in healthy children and adolescents: a study using peripheral quantitative computed tomography. Bone. 2001;28:227-232. (Pubitemid 32140979)
30. Neu CM, Rauch F, Manz F, Schönau E. Modeling of cross-sectional bone size, mass and geometry at the proximal radius: a study of normal bone development using peripheral quantitative computed tomography. Osteoporos Int. 2001;12:538-547. (Pubitemid 32777429)
31. Moyer-Mileur LJ, Quick JL, Murray MA. Peripheral quantitative computed tomography of the tibia: pediatric reference values. J Clin Dens. 2008;11:283-294.
32. Frost HM. Bone mass and the mechanostat: a proposal. Anat Rec. 1987;219:1-9.
33. Rauch F, Bailey D, Baxter-Jones A, Mirwald R, Faulkner R. The 'muscle-bone unit' during the pubertal growth spurt. Bone. 2004; 34:771-775. (Pubitemid 38581121)
34. Rauch F. The dynamics of bone structure development during pubertal growth. J Musculoskelet Neuronal Interact. 2012;12: 1-6.
35. Marcus R, Leary D, Schneider DL, Shane E, Favus M, Quigley CA. The contribution of testosterone to skeletal development and maintenance: lessons from the androgen insensitivity syndrome. J Clin Endocrinol Metab. 2000;85:1032-1037. (Pubitemid 32269345)
36. Weise M, De-Levi S, Barnes KM, Gafni RI, Abad V, Baron J. Effects of estrogen on growth plate senescence and epiphyseal fusion. Proc Natl Acad Sci USA. 2001;98:6871-6876. (Pubitemid 32538309)
37. Loesch DZ, Hopper JL, Rogucka E, Huggins RM. Timing and genetic rapport between growth in skeletal maturity and height around puberty: similarities and differences between girls and boys. Am J Hum Genet. 1995;56:753-759.
38. Nilsson O, Chrysis D, Pajulo O, et al. Localization of estrogen receptors-α and -β and androgen receptor in the human growth plate at different pubertal stages. J Endocrinol. 2003;177:319-326. (Pubitemid 36656405)
39. Moverare S, Venken K, Eriksson AL, et al. Differential effects on bone of estrogen receptor α and androgen receptor activation in orchidectomized adult male mice. Proc Natl Acad Sci USA. 2003; 100:13573-13578. (Pubitemid 37448563)