Quantitative proteomics analysis reveals similar release profiles following specific PAR-1 or PAR-4 stimulation of platelets

Cardiovascular Research

Volumn 103, Issue 1, 2014, Pages 140-146

  Van Holten, Thijs C ^a   Bleijerveld, Onno B ^a,b,c,d   Wijten, Patrick ^b,c,d   De Groot, Philip G ^a   Heck, Albert J R ^b,c,d   Barendrecht, Arjan D ^a   Merkx, Tesy H ^a   Scholten, Arjen ^b,c,d   Roest, Mark ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

Author keywords

Platelets; Protease activated receptor; Quantitative proteomics; Releasate; Thrombosis

Indexed keywords

BETA THROMBOGLOBULIN; ENDOSTATIN; PLATELET DERIVED GROWTH FACTOR AB; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; RANTES; STROMAL CELL DERIVED FACTOR 1; THROMBOCYTE FACTOR 4; THROMBOSPONDIN; VASCULOTROPIN; APOPTOSIS REGULATORY PROTEIN; CXCL12 PROTEIN, HUMAN; FIBRINOGEN; FIBRINOGEN RECEPTOR; PADGEM PROTEIN; PPBP PROTEIN, HUMAN; PROSTATE APOPTOSIS RESPONSE-4 PROTEIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEOMICS; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; THROMBOCYTE ACTIVATION; ANGIOGENESIS; BLOOD; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS); SECRETORY VESICLE; THROMBOCYTE;

APOPTOSIS REGULATORY PROTEINS; BETA-THROMBOGLOBULIN; BLOOD PLATELETS; CHEMOKINE CXCL12; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRINOGEN; HUMANS; MASS SPECTROMETRY; NEOVASCULARIZATION, PHYSIOLOGIC; P-SELECTIN; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEOMICS; RECEPTOR, PAR-1; SECRETORY VESICLES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84904016724     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu113     Document Type: Article

References (12)

1. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-3384.
2. Smyth SS, McEver RP,Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC. Platelet functions beyond hemostasis. J Thromb Haemost 2009;7:1759-1766.
3. Chatterjee M, Huang Z, ZhangW, Jiang L, Hultenby K, Zhu L, Hu H, Nilsson GP, Li N. Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli. Blood 2011;117:3907-3911.
4. Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Angiogenesis is regulated by a novel mechanism: pro-and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008;111:1227-1233.
5. Ma L, Perini R, McKnight W, Dicay M, Klein A, Hollenberg MD, Wallace JL. Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci USA 2005;102:216-220.
6. Kamykowski J, Carlton P, Sehgal S, Storrie B. Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet alpha-granules. Blood 2011;118:1370-1373.
7. van Nispen tot Pannerden H, de Haas F, GeertsW, Posthuma G, van Dijk S, Heijnen HF. The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes. Blood 2010;116:1147-1156.
8. Jonnalagadda D, Izu LT, Whiteheart SW. Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood 2012;120:5209-5216.
9. Wijten P, van Holten TC,Woo LLB, Bleijerveld OB, Roest M, Heck AJ, Scholten A. High precision platelet releasate definition by quantitative reversed protein profiling. 2013; doi:10.1161/ATVBAHA.113.301147.
10. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest 1999;103:879-887.
11. SambranoGR, HuangW, FaruqiT,Mahrus S, Craik C, Coughlin SR. CathepsinGactivates protease-activated receptor-4 in human platelets. J Biol Chem 2000;275:6819-6823.
12. Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE. PAR-4, but not PAR-1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. J Biol Chem 2006;281:26665-26674.