Ultrasound-assisted one-pot four-component synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole scaffold and their biological broadcast

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 655-664

  Kalaria, Piyush N ^a   Satasia, Shailesh P ^a   Avalani, Jemin R ^a   Raval, Dipak K ^a  

^a SARDAR PATEL UNIVERSITY   (India)

Author keywords

5 Imidazopyrazole; Antimicrobial activity; Antituberculosis activity; FRAP assay; Pyridine derivatives; Ultrasound

Indexed keywords

2 AMINO 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL] 6 (2 OXO 3H CHROMEN 3 YL)NICOTINONITRILE; 2 AMINO 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL] 6 (THIOPHEN 2 YL)NICOTINONITRILE; 2 AMINO 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL] 6 PHENYLNICOTINONITRILE; 2 AMINO 6 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL) 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL] 6 (2 OXO 3H CHROMEN 3 YL)NICOTINONITRILE; 2 AMINO 6 (4 BROMOPHENYL) 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL]NICOTINONITRILE; 2 AMINO 6 (4 CHLOROPHENYL) 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL]NICOTINONITRILE; 2 AMINO 6 (4 FLUOROPHENYL) 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL]NICOTINONITRILE; 2 AMINO 6 (4 METHOXYPHENYL) 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL]NICOTINONITRILE; 2 AMINO 6 (FURAN 2 YL) 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL]NICOTINONITRILE; 3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOLE 4 CARBALDEHYDE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (2 OXO 3H CHROMEN 3 YL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (2,2 DIMETHYLBENZO[D][1,3]DIOXOL 5 YL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (4 BROMOPHENYL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (4 CHLOROPHENYL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (4 FLUOROPHENYL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (4 METHOXYPHENYL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (FURAN 2 YL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 (THIOPHEN 2 YL)NICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 2 AMINO 6 PHENYLNICOTINONITRILE; 4 [5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL] 6 [(1,1' BUPHENYL) 4 YL] 2 AMINONICOTINONITRILE; 5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOLE 4 CARBALDEHYDE; 6 [(1,1' BUPHENYL) 4 YL] 2 AMINO 4 [3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL] NICOTINONITRILE; AMPICILLIN; ASCORBIC ACID; GRISEOFULVIN; ISONIAZID; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; 2 AMINO 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL) 6 (2 OXO 2H CHROMEN 3 YL)NICOTINONITRILE; 2 AMINO 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL) 6 (THIOPHEN 2 YL)NICOTINONITRILE; 2 AMINO 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL) 6 PHENYLNICOTINONITRILE; 2 AMINO 6 (2,2 DIMETHYLBENZO [D] [1,3] DIOXOL 5 YL) 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL)NICOTINONITRILE; 2 AMINO 6 (4 BROMOPHENYL) 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL)NICOTINONITRILE; 2 AMINO 6 (4 CHLOROPHENYL) 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL)NICOTINONITRILE; 2 AMINO 6 (4 FLUOROPHENYL) 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL)NICOTINONITRILE; 2 AMINO 6 (4 METHOXYPHENYL) 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL)NICOTINONITRILE; 2 AMINO 6 (FURAN 2 YL) 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL)NICOTINONITRILE; 4 (5 (1 IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (4 METHOXYPHENYL)NICOTINONITRILE; 4 (5 (1 IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (FURAN 2 YL)NICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (2 OXO 2H CHROMEN 3 YL)NICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (2,2 DIMETHYLBENZO [D] [1,3] DIOXOL 5 YL)NICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (4 BROMOPHENYL)NICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (4 CHLOROPHENYL)NICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (4 FLUOROPHENYL)NICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 (THIOPHEN 2 YL)NICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 2 AMINO 6 PHENYLNICOTINONITRILE; 4 (5 (1H IMIDAZOL 1 YL) 3 METHYL 1 PHENYL 1H PYRAZOL 4 YL) 6 [(1,1' BIPHENYL) 4 YL] AMINONICOTINONITRILE; 6 [(1,1' BIPHENYL)4 YL] 2 AMINO 4 (3 METHYL 5 (4 METHYL 1H IMIDAZOL 1 YL) 1 PHENYL 1H PYRAZOL 4 YL)NICOTINONITRILE; ANTIINFECTIVE AGENT; ANTIOXIDANT; TUBERCULOSTATIC AGENT; 3-CYANOPYRIDINE; IMIDAZOPYRAZOLE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTITUBERCULOSIS ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; CLOSTRIDIUM TETANI; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; KNOEVENAGEL CONDENSATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SALMONELLA TYPHI; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; ULTRASOUND; VIBRIO CHOLERAE; POLYMERIZATION; REACTION TIME; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHI; CHEMISTRY; DRUG EFFECTS; FUNGUS; SYNTHESIS;

ANTIOXIDANTS; ANTITUBERCULAR AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; FUNGI; MYCOBACTERIUM TUBERCULOSIS; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; ULTRASONICS;

EID: 84903993164     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.071     Document Type: Article

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