Statistical and methodological concerns about the beneficial effect of neuraminidase inhibitors on mortality

The Lancet Respiratory Medicine

Volumn 2, Issue 7, 2014, Pages e9-e10

  Jones, Mark ^a   Del Mar, Chris ^b   Hama, Rokuro ^c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b BOND UNIVERSITY   (Australia)

^c Japan Institute of Pharmacovigilance   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SIALIDASE INHIBITOR; ANTIVIRUS AGENT; ENZYME INHIBITOR; OSELTAMIVIR; SIALIDASE; ZANAMIVIR;

DRUG EFFICACY; DRUG EXPOSURE; DRUG USE; GOVERNMENT; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; LETTER; MORTALITY; OUTCOME ASSESSMENT; PANDEMIC INFLUENZA; PRIORITY JOURNAL; PUBLIC HEALTH; RISK ASSESSMENT; STATISTICAL ANALYSIS; ANTAGONISTS AND INHIBITORS; FEMALE; INFLUENZA VIRUS A H1N1; INFLUENZA, HUMAN; MALE; PANDEMIC;

ANTIVIRAL AGENTS; ENZYME INHIBITORS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MALE; NEURAMINIDASE; OSELTAMIVIR; PANDEMICS; ZANAMIVIR;

EID: 84903943315     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(14)70126-2     Document Type: Letter

References (5)

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2. Van Walraven C, Davis D, Forster A, Wells G Time-dependent bias was common in survival analyses published in leading clinical journals. J Clin Epidemiol 2004, 57:672-682.
3. Beyersmann J, Gastmeier P, Wolkewitz M, Schumacher M An easy mathematical proof showed that time-dependent bias inevitably leads to biased effect estimation. J Clin Epidemiol 2008, 61:1216-1221.
4. Siston A, Rasmussen S, Honein M, et al. Pandemic 2009 influenza A (H1N1) virus illness among pregnant women in the United States. JAMA 2010, 303:1517-1525.
5. Study claiming Tamiflu saved lives was based on "flawed" analysis-recent rapid responses, (accessed May 19, 2014). http://www.bmj.com/content/348/bmj.g2228?tab=responses.