A review on solubility enhancement using hydrotropic phenomena

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 6, Issue 6, 2014, Pages 1-7

  Sampath Kumar, V ^a   Raja, C ^a   Jayakumar, C ^a  

^a ANNA UNIVERSITY   (India)

Author keywords

Bioavailability; Hydrophobic drugs; Hydrotropes; Hydrotropy; Mixed hydrotropy; Solubility; Solubility enhancement

Indexed keywords

HYDROTROPE; QUATERNARY AMMONIUM DERIVATIVE; THIOCYANIC ACID DERIVATIVE;

ANALYTIC METHOD; CO SOLVENCY; COST EFFECTIVENESS ANALYSIS; CRITICAL MICELLE CONCENTRATION; CRYSTALLIZATION; DRUG BIOAVAILABILITY; DRUG SELECTIVITY; DRUG SOLUBILITY; EVAPORATION; GRAVIMETRY; HYDROTROPIC SOLUBILISATION; MICELLAR SOLUBILIZATION; MIXED HYDROTROPY; NANOTECHNOLOGY; PARTICLE SIZE; PHASE TRANSITION; REVIEW; SALTING IN; SALTING OUT; SOLUBILIZATION; SPRAY DRYING; SULFONATION; SUPPOSITORY; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 84903904252     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Review

References (76)

1. Neuberg C. Hydrotropy. Biochem. Z. 1916; 76: 107-109.
2. Booth H. S, Everson H. E. Hydrotropic solubilities in aqueous sodium o-, m-and p-xylene sulfonate solutions. Ind. Eng. Chem. 1950;. 42: 1536-1537.
3. Booth H. S, Everson H. E. Hydrotropic solubilities. Ind. Eng. Chem. 1949; 41: 2627-2629.
4. Booth H. S, Everson H. E. Hydrotropic solubilities in 40% sodium xylene sulfonate Solutions. Ind. Eng. Chem. 1948; 40: 1491-1493.
5. Balasubramanian D, Srinivas V, Gaikar V. G., and Sharma M. M. Aggregation behavior of hydrotropes in aqueous solutions. Journal Physical Chemistry. 1989; 93: 3865-3870.
6. Mckee R. H. Use of hydrotrope solutions in Industry. Ind. Eng. chem. 1946; 38: 382.
7. Rodriguez A, Gracini M, Moya M. L. Effects of addition of polar organic solvents on micellization. Langmuir., 2008; 24: 12785-2790.
8. Badwan A. A, El-Khordagui L. K, Saleh A. M. The solubility of benzodiazepines in sodium salicylate solutions and a proposed mechanism for hydrotropic solubilisation. Int. J. Pharm. 1983; 13: 67-74.
9. Pandit A, Sharma M. M. Intensification of heterogeneous reactions through hydrotropy. Alkaline hydrolysis of esters and oximation of cyclododecanone. Chem. Eng. Sci. 1987; 42: 2519-2523.
10. Chen X, Micheu J. C. Hydrotrope Induced auto catalysis in the biphasic alkaline hydrolysis of aromatic esters. J. Colloid Interface Sci. 2002; 249: 172-179.
11. Akhilesh Kumar Jain. Solubilization of indomethacin using hydrotropes for aqueous injection. European Journal of Pharmaceutics and iopharmaceutics. 2008; 68: 701-714.
12. Maheshwari R. K, Chaturvedi S. C, Jain N. K. Novel application of hydrotropic Solubilization in the quantitative analysis of some NSAIDs and their solid dosage forms. Indian J. Pharm. Sci. 2007; 69: 101-105.
13. Dandekar D. V, Gaikar V. G. Hydrotropic extraction of curcuminoids from turmeric. Sep. Sci. Technol. 2003; 38(5): 1185-1215.
14. Colonia E. J, Dixit A. B, Tavare N. S. Separation of o-and p-chlorobenzoic acids: hydrotropy and precipitation. J. Crys. Growth. 1996; 166: 976-980.
15. Coffman R. E, Kildsig D. O. Hydrotropic solubilization-mechanistic studies. Pharmaceutical Research. 1996; 13(10): 1460-1463.
16. Dharmesh Varade, Pratap Bahadur. Effect of hydrotropes on the aqueous solution behavior of surfactants. Journal of Surfactants and Detergents. 2004; 7(3): 257-261.
17. Dharmendira Kumar M, Nagendra Gandhi, N. Effect of hydrotropes on solubility and mass transfer coefficient of amyl acetate. Bio process. Eng. 2000; 23: 31-36.
18. Dharmendira Kumar M, Nagendra Gandhi N. Effect of hydrotropes on solubility and mass transfer coefficient of methyl salicylate. J. Chem. Eng. 2000; 45: 419-423.
19. Deno N. C, Spink C. H. The Mc-Devit long equation for salt effects on non-electrolytes. J. Phys. Chem. 1963; 67: 1347-1349.
20. Friberg S. E. Hydrotropes. Surf. Sci. Z. 1997; 2: 490-494.
21. Gaspar Gonzalez, Eduardo J, Nassar, Maria Elizabete D, Zaniquelli. Examination of the Hydrotropic Effect of Sodium p-Toluenesulfonate on a Nonionic Surfactant (C12E6) Solution. Journal of Colloid and Interface Science. 2000; 230(2): 223-228.
22. Iqrar Ahmad Khan, Ahmad Jahan Khanam, Mohmad Shafi Sheikh, Kabir-ud-Din. Influence of ionic and nonionic hydrotropes on micellar behavior of a cationic gemini surfactant butanediyl-1, 4-bis(dimethyl cetyl ammonium bromide). Journal of Colloid and Interface Science. 2011; 359(2): 467-473.
23. Jadhav V. K, Dixit B. A, Tavare N. S. Solubilities of m-and Paminoacetophenones in hydrotrope solutions. J. Chem. Eng. Data. 1995; 40: 669-673.
24. Paul O, Raynaud-Lacroze, Narayan S, Tavare. Separation of 2-Naphthol: Hydrotropy and Precipitation. Ind. Eng. Chem. Res. 1993; 32: 685-691.
25. Travis K, Hodgdon, Eric W. Kaler. Hydrotropic solutions. Current Opinion in Colloidand Interface Science. 2007; 3: 121-128.
26. Maheshwari R. K, Gupta HM, Singh M, Ramchandani U, Pandey S. A novel application of hydrotropic solubilization in the spectrophotometric analysis of gatifloxacin in solid dosage form. Asian J Chem. 2008; 20 (1): 241-4.
27. Raynaud-Lacroze P. O, Tavare N. S. Separation of 2-naphthol: Hydrotropy and Precipitation,. Ind. Eng. Chem. Res. 1993; 32: 685-691.
28. Friberg S. E, Yang Y, Huang T. A. Reversible extraction process of phenyl ethyl alcohol a fragrance. Ind. Eng. Chem. Res. 1996; 35: 2856-2859.
29. Jain P, Goel A, Sharma S, Parmar M. Solubility Enhancement Techniques with Special Emphasis On Hydrotrophy. International Journal of Pharma Professional's Research July 2010; 1(1): 34-45.
30. Behera AL, Sahoo SK, Patil SV. Enhancement of solubility: a pharmaceutical overview. Der Pharmacia Lettre. 2010; 2(2): 310-318.
31. Sharma R, Pathodiya G, Mishra PG. A novel application of hydrotropic solubilization indevelopment and validation of spectrophotometric method forsimultaneous estimation of paracetamol and diclofenac sodium in solid dosage form International Journal of Pharma and Bio Sciences 2010; 1(3): 1-9.
32. Sara Nicoli, Franca Zani, Stefania Bilzi, Ruggero Bettini & Patrizia Santi. Association of nicotinamide with parabens: Effect on solubility, partition and transdermal permeation European Journal of Pharmaceutics and Biopharmaceutics. 2008; 69(2): 613-621.
33. Deepak V, Dandekar, Jayaprakasha G. K, Bhimanagouda S. Patil. Hydrotropic extraction of bioactive limonin from sour orange (Citrus aurantium L.) seeds Food Chemistry. 2008; 109(3): 515-520.
34. Gibson. Pharmaceutical preformulation and formulation. 2nd ed. Interpharm Press. 2001: 28-29.
35. Martin A. Micromeritics in physical pharmacy. 2nd ed. Phikadelphia PA. 1988: 273.
36. Goel A, Sharma M, Sharma S, Haffez A, Arora J. Pharmacokinetic data and solubility profile of antihypertensive drugs. Int J Pharma Prof Res. 2010; 1: 61-77.
37. Goel A, Saini S, Chowdhry V, Haider SA, Singh RK. Pharmacokinetic solubility and dissolution profile of anticancer drugs. Int J Pharma Prof Res. 2011; 2(4): 502-539.
38. Goel A, Aggarwal S, Partap S, Saurabh A, Choudhary V. Pharmacokinetic solubility and dissolution profile of antiarrythmic drugs. Int J Pharma Prof Res. 2012; 3(1): 592-601.
39. Sanjay P. Mishra; V. G. Gaikar. Aqueous Hydrotropic Solution as an Efficient Solubilizing Agent for Andrographolide from Andrographis paniculata Leaves. Separation Science and Technology. 2006; 41: 1115-1134.
40. Pahala Simamora, Joan M, Alvarez, Samuel H, Yalkowsky. Solubilization of rapamycin Pahala Simamora. International Journal of Pharmaceutics. 2001; 213: 25-29.
41. Gaikar, V. G. and P. V. Phatak, 1999. Selective solubilization of isomers in hydrotrope solutions: o-/p-chlorobenzoic acids and o-/pnitroanilines. Sep. Sci. Technol., 34(3): 439-459.
42. Yiyang Lin, Yan Qiao, Xinhao Cheng, Yun Yan, Zhibo Li Jianbin Huang. Journal of Colloid and Interface Science. 2012; 369: 238-244.
43. Ankit Mangal, Sandeep Singh Bhadoriya, Sorabh Joshi, Gaurav Agrawal, Amit Gupta, Narendra Mandoria. Extraction Of Herbal Drugs By Using Hydrotropy Solublization Phenomenon. Int. Res j pharm. App sci., 2012; 2(1): 63-74.
44. Friberg E, Brancewicz C. O/W Microemulsions and hydrotropes: The coupling action of a hydrotrope. Langmuir. 1994; 10: 2945-2949.
45. Jouyban A, Chew NY, Chan HK, Sabour M, Acree WE Jr. A unified cosolvency model for calculating solute solubility in mixed solvents. Chem Pharm Bull (Tokyo). 2005: 53(6): 634-7.
46. Senthilnathan M, Jayakumar C, Nagendra Gandhi N., Effect of Hydrotropes on the solubility and Mass Transfer Coefficient of Methyl Salicylate, Canadian Journal of Modern Applied Science, 2009; 3: 101-11.
47. Jayakumar C., Nagendra Gandhi N., Hydrotropic study on Furfural-Comprehensive Design Expert Plot, Modern Applied Science. 2009; 3: 117-130.
48. Jayakumar C, Deepakkumar K, Nesakumar D, Nagendra Gandhi N, Quantitative analysis of Theophylline bulk sample using Sodium salicylate hydrotrope. Indian J. Pharm. Sci. 2010; 0975-1491.
49. Shinde A. J. Solubilization of poorly soluble drugs. A Review. Pharmainfo. net. 2007; 5: 6.
50. Hydrotropes. Technical Bulletin: Pilot chemical company.
51. Tirucherai G S, Mitra A K. Effect of hydroxypropyl beta cyclodextrin complexation on aqueous solubility, stability, and corneal permeation of acyl ester prodrugs of ganciclovier. AAPS Pharm. Sci. Tech. 4: 2003: E45.
52. Strickley R. G. Solubilizing excipients in oral and injectable formulations. Pharm. Res. 2004; 21: 201-230.
53. Nema S, Washkuhn R. J, Brendel R. J. Excipients and their use in injectable products. Pharm. Sci. Technol. 1997; 51: 166-171.
54. Rubino J T, Yalkowsky S H. Co-solvency and deviations from loglinear solubilization. Pharm. Res. 1987; 4: 231-236.
55. Shiv M. Solubility Enhancement: Need. pharmainfo. net. 2009.
56. Trease and Evanse: Pharmacognosy. Rajkamal Electric press Delhi 526 15th edition 2005.
57. Jain P, Goel A, Sharma S, Parmar M. Solubility Enhancement Techniques with Special Emphasis On Hydrotrophy. International Journal of Pharma Professional's Research. 2010; 1(1): 34-45.
58. Zaheer A, Naveen M, Santosh MK, Imran K, Solubility enhancement of poorly water soluble drugs, Int J PharmTech. 2011; 3 (1): 807-823.
59. Nidhi K, Indrajeet S, Khushboo M, Gauri K, Sen DJ, Hydrotropy: a promising tool for solubility enhancement, Int J Drug Dev Res. 2011; 3(2) 26-33.
60. Rong Guo, Qiqing Zhang, Junhong Qian, Aihua Zou. Hydrotrope and hydrotrope-solubilization action of penicillin-K in CTAB/n-C 5H11OH/H2O system. Physicochemical and Engineering Aspects. 2002; 196: 223-234.
61. Subir Kumar Das, Shrabani Das B. Nandi Ganguly, Amarnath Maitra. Self association of sodium salicylate system. Chemical Physics. 2003; 293: 211-216.
62. Shete A S, Yadav AV, Dabke A. P. Sakhare S. S. Formulation and Evaluation of Hydrotropic Solublization Based Suspensions of Griseofulvin. International Journal of Pharma Sciences and Research (IJPSR). 2010; 1(1): 51-57.
63. Marios Hopkins Hatzopoulos, Julian Eastoe, Peter J. Dowding, Isabelle Grillo, Bruno Demé, Sarah E. Rogers, Richard Heenan, and Robert Dyer. Effects of Structure Variation on Solution Properties of Hydrotropes: Phenyl versus Cyclohexyl Chain Tips. Langmuir. 2012; 28: 9332-9340.
64. Sharma D, Soni M, Kumar S, Gupta GD. Solubility enhancement-eminent role in poorly soluble drugs. Research Journal of Pharmacy and Technology. 2009; 2(2): 220-224.
65. Vemula VR, Lagishetty V, Lingala S. Solubility enhancement techniques. International Journal of Pharmaceutical Sciences Review and Research. 2010; 5(1): 41-51.
66. Kumar A, Sahoo SK, Padhee K, Kochar PS, Sathapathy A, Pathak N. Review on solubility enhancement techniques for hydrophobic drugs. Pharmacie Globale. 2011; 3(3): 1-7.
67. Jain P, Goel A, Sharma S, Parmar M. Solubility Enhancement Techniques with Special Emphasis on Hydrotrophy. International Journal of Pharma Professional's Research. 2010; 1(1): 34-45.
68. Marios Hopkins Hatzopoulos, Julian Eastoe, Peter J. Dowding, Isabelle Grillo, Bruno Demé, Sarah E. Rogers, Richard Heenan, and Robert Dyer. Effects of Structure Variation on Solution Properties of Hydrotropes: Phenyl versus Cyclohexyl Chain Tips. Langmuir, 2012; 28 (25): 9332-9340.
69. More HN, Hajare AA. Practical physical pharmacy. Career publication, 2010: 230.
70. Maheshwari RK. Analytical techniques using hydrotropic solubilization [Thesis]. Department of Pharmacy, Shri G. S. Institute of Technology and Science, Indore. 2008; 61-62.
71. R. K. Maheshwari, S. R. Bishnoi, D. Kumar, Murali Krishna. Quantitative spectrophotometric determination of ornidazole tablet formulations using ibuprofen sodium as hydrotropic solubilizing agent Digest. Journal of Nanomaterials an Biostructures. 2009; 4(4): 751-754.
72. Maheshwari RK, Sharma S, Rai N, Rajput M. Simple titrimetric method to estimate ketoprofen in bulk using mixed hydrotropy. Journal of Pharmacy Research 2010; 3(3): 442-443.
73. Jain N, Jain R, Thakur N, Gupta B, Banweer J, Jain S. Novel spectrophotometric quantitative estimation of hydrochlorothiazide in bulk drug and their dosage forms by using hydrotropic agent. IntJ. Appl. Pharma. 2010; 2(3): 1114.
74. Sharma R, Pathodiya G, Mishra PG. A novelapplication of hydrotropic solubilization indevelopment and validation of spectrophotometric method forsimultaneous estimation of paracetamol and diclofenac sodium in solid dosage form International Journal of Pharma and Bio Sciences 2010; 1(3): 1-9.
75. Santosh Bhalerao, Santosh Tambe, Vikas Pareek, Rup ali Shinde, Lalit Kumar Gupta. A solid-liquid extraction and high performance thin layer chromatographic determination of diacerein and aceclofenac in pharmaceutical tablet dosage form. Asian journal pharmaceutical and clinical Research. 2010; 3(1): 25-30.
76. Jain P, Goel A, Sharma S, Parmar M. Solubility Enhancement Techniques with Special Emphasis on Hydrotrophy. International Journal of Pharma Professional's Research July 2010; 1(1): 34-45.