Interferon alfa therapy in CALR-mutated essential thrombocythemia

New England Journal of Medicine

Volumn 371, Issue 2, 2014, Pages 188-189

  Cassinat, Bruno ^a   Verger, Emmanuelle ^a   Kiladjian, Jean Jacques ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CALRETICULIN; JANUS KINASE 2; PEGINTERFERON ALPHA2A; THROMBOPOIETIN RECEPTOR;

ADULT; CALCIRETICULIN GENE; CASE REPORT; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; FEMALE; FOLLOW UP; GENE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; HIGH RISK PATIENT; HUMAN; JANUS KINASE 2 GENE; LETTER; MEDICAL HISTORY; MIDDLE AGED; MOLECULAR CLONING; MOLECULAR DYNAMICS; MYELOPROLIFERATIVE NEOPLASM; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; THROMBOCYTHEMIA; THROMBOPOIETIN RECEPTOR GENE;

CALRETICULIN; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; INTERFERON-ALPHA; JANUS KINASE 2; MALE; MIDDLE AGED; MUTATION; THROMBOCYTHEMIA, ESSENTIAL;

EID: 84903879916     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1401255     Document Type: Letter

References (5)

1. Klampfl T, Gisslinger H, Harutyunyan AS, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med 2013;369:2379-90.
2. Nangalia J, Massie CE, Baxter EJ, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 2013;369:2391-405.
3. Kiladjian JJ, Cassinat B, Chevret S, et al. Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. Blood 2008;112:3065-72.
4. Yue X, Wang H, Zhao F, et al. Hepatitis B virus-induced calreticulin protein is involved in IFN resistance. J Immunol 2012;189:279-86.
5. Barbui T, Barosi G, Birgegard G, et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 2011;29:761-70.