The effects of designation and volume of neonatal care on mortality and morbidity outcomes of very preterm infants in England: Retrospective population-based cohort study

BMJ Open

Volumn 4, Issue 7, 2014, Pages

  Watson, S I ^a   Arulampalam, W ^b   Petrou, S ^a   Marlow, N ^c   Morgan, A S ^c   Draper, E S ^d   Santhakumaran, S ^e   Modi, N ^e  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIRTH WEIGHT; CAUSE OF DEATH; CLINICAL STUDY; COHORT ANALYSIS; ENTEROCOLITIS; FEMALE; GESTATIONAL AGE; HEALTH CARE UTILIZATION; HIGH VOLUME HOSPITAL; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INFANT; LUNG DYSPLASIA; MALE; NATIONAL HEALTH SERVICE; NECROTISING ENTEROCOLITIS; NEWBORN CARE; NEWBORN MORBIDITY; NEWBORN MORTALITY; OUTCOME ASSESSMENT; PREMATURITY; RETROLENTAL FIBROPLASIA; RETROSPECTIVE STUDY; SENSITIVITY ANALYSIS; TERTIARY HEALTH CARE; UNITED KINGDOM; VERY LOW BIRTH WEIGHT; ENGLAND; HOSPITAL MORTALITY; INFANT MORTALITY; INFANT, PREMATURE, DISEASES; MORTALITY; NEONATAL INTENSIVE CARE UNIT; NEWBORN; STATISTICS AND NUMERICAL DATA;

COHORT STUDIES; ENGLAND; FEMALE; HOSPITAL MORTALITY; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INTENSIVE CARE UNITS, NEONATAL; MALE; RETROSPECTIVE STUDIES;

EID: 84903849022     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2014-004856     Document Type: Article

References (36)

1. Lasswell SM, Barfield WD, Rochat RW, et al. Perinatal regionalization for very low-birth-weight and very preterm infants: a meta-analysis. JAMA 2010;304:992-1000.
2. Phibbs CS, Baker LC, Caughey AB, et al. Level and volume of neonatal intensive care and mortality in very-low-birth-weight infants. N Engl J Med 2007;356:2165-75. (Pubitemid 47010842)
3. Cifuentes J, Bronstein J, Phibbs CS, et al. Mortality in low birth weight infants according to level of neonatal care at hospital of birth. Pediatrics 2002;109:745-51. (Pubitemid 34493337)
4. Chung JH, Phibbs CS, Boscardin WJ, et al . The effect of neonatal intensive care level and hospital volume on mortality of very low birth weight infants. Med Care 2010;48:635-44.
5. Rogowski JA, Horbar JD, Staiger DO, et al. Indirect vs direct hospital quality indicators for very low-birth-weight infants. JAMA 2004;291:202-9. (Pubitemid 38082814)
6. Bartels DB, Wypij D, Wenzlaff P, et al. Hospital volume and neonatal mortality among very low birth weight infants. Pediatrics 2006;117:2206-14. (Pubitemid 46071267)
7. Lorch SA, Baiocchi M, Ahlberg CE, et al. The differential impact of delivery hospital on the outcomes of premature infants. Pediatrics 2012;130:270-8.
8. Fellman V, Hellström-Westas L, Norman M, et al. One-year survival of extremely preterm infants after active perinatal care in Sweden. JAMA 2009;301:2225-33.
9. Johansson S, Montgomery SM, Ekbom A, et al. Preterm delivery, level of care, and infant death in Sweden: a population-based study. Pediatrics 2004;113:1230-5. (Pubitemid 38580685)
10. Rautava L, Lehtonen L, Peltola M, et al. The effect of birth in secondary- or tertiary-level hospitals in Finland on mortality in very preterm infants: a birth-register study. Pediatrics 2007;119:e257-63. (Pubitemid 46397833)
11. Synnes AR, Macnab YC, Qiu Z, et al. Neonatal intensive care unit characteristics affect the incidence of severe intraventricular hemorrhage. Med Care 2006;44:754-9. (Pubitemid 44284266)
12. Phibbs CS. Managed clinical networks in neonatal care. BMJ 2012;344:e2423.
13. Department of Health. Report of Department of Health Working Group on Neonatal Intensive Care Services. London, 2003.
14. Gale C, Santhakumaran S, Nagarajan S, et al. Impact of managed clinical networks on NHS specialist neonatal services in England: population based study. BMJ 2012;344:e2105.
15. Tucker J. Patient volume, staffing, and workload in relation to risk-adjusted outcomes in a random stratified sample of UK neonatal intensive care units: a prospective evaluation. Lancet 2002;359:99-107. (Pubitemid 34112536)
16. Hamilton KESC, Redshaw ME, Tarnow-Mordi W. Nurse staffing in relation to risk-adjusted mortality in neonatal care. Arch Dis Child Fetal Neonatal Ed 2007;92:F99-103.
17. Van Reempts P, Gortner L, Milligan D, et al. Characteristics of neonatal units that care for very preterm infants in Europe: results from the MOSAIC study. Pediatrics 2007;120:e815-25. (Pubitemid 47549524)
18. Department of Health. Reforming NHS financial flows: introducing payment by results. London. 2002.
19. Ehrenkranz RA, Walsh MC, Vohr BR, et al. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics 2005;116:1353-60. (Pubitemid 46056482)
20. Medlock S, Ravelli ACJ, Tamminga P, et al. Prediction of mortality in very premature infants: a systematic review of prediction models. PLoS ONE 2011;6:e23441.
21. Noble M, McLennan D,Wilkinson K, et al. English Indices of Deprivation 2007. Communities and Local Government, London. 2008.
22. British Association of Perinatal Medicine. Categories of care. 2011. http://www.bapm.org/publications/documents/guidelines/CatsofcarereportAug11.pdf (accessed 12 Jun 2012).
23. Office for National Statistics. Super output areas. 2011. http://www.ons.gov.uk/ons/guide-method/geography/beginner-s-guide/census/ super-output-areas--soas-/index.html (accessed 12 Feb 2013).
24. Smith LK, Draper ES, Manktelow BN, et al. Socioeconomic inequalities in very preterm birth rates. Arch Dis Child Fetal Neonatal Ed 2007;92:F11 -14.
25. Terza JV, Basu A, Rathouz PJ. Two-stage residual inclusion estimation: addressing endogeneity in health econometric modeling. J Health Econ 2008;27:531-43.
26. Tsai AC, Votruba M, Bridges JFP, et al. Overcoming bias in estimating the volume-outcome relationship. Health Serv Res 2006;41:252-64.
27. Imbens G, Angrist J. Identification and estimation of local average treatment effects. Econometrica 1994;62:467-75.
28. Heller G, Richardson DK, Schnell R, et al. Are we regionalized enough? Early-neonatal deaths in low-risk births by the size of delivery units in Hesse, Germany 1990-1999. Int J Epidemiol 2002;31:1061-8. (Pubitemid 35446884)
29. Moster D, Lie RT, Markestad T. Relation between size of delivery unit and neonatal death in low risk deliveries: population based study. Arch Dis Child Fetal Neonatal Ed 1999;80:F221-5. (Pubitemid 29453044)
30. Bowman E, Doyle LW, Murton LJ, et al. Increased mortality of preterm infants transferred between tertiary perinatal centres. BMJ 1988;297:1098-100.
31. Lee SK, Zupancic JA, Pendray M, et al. Transport risk index of physiologic stability: a practical system for assessing infant transport care. J Pediatr 2001;139:220-6. (Pubitemid 32721708)
32. Mistry H, Dowie R, Franklin RCG, et al. Costs of neonatal care for low-birthweight babies in English hospitals. Acta Paediatr 2009;98:1123-9.
33. Gale C, Hay A, Philipp C, et al. In-utero transfer is too difficult: results from a prospective study. Early Hum Dev 2012;88:147-50.
34. Binder S, Hill K, Meinzen-Derr J, et al. Increasing VLBW deliveries at subspecialty perinatal centers via perinatal outreach. Pediatrics 2011;127:487-93.
35. Neto MT. Perinatal care in Portugal: effects of 15 years of a regionalized system. Acta Paediatr 2006;95:1349-52. (Pubitemid 44643545)
36. Delamothe T, Godlee F. Dr Lansley 's monster. BMJ 2011;342:d408.