Rapid diagnosis of tuberculosis using ex vivo host biomarkers in sputum

European Respiratory Journal

Volumn 44, Issue 1, 2014, Pages 254-257

  Ota, Martin O C ^a   Mendy, Joseph F ^a   Donkor, Simon ^a   Togun, Toyin ^a   Daramy, Mohammed ^a   Gomez, Marie P ^a   Chegou, Novel N ^b   Sillah, Abdou K ^a   Owolabi, Olumuyiwa ^a   Kampmann, Beate ^a   Walzl, Gerhard ^b   Sutherland, Jayne S ^a  

^a Vaccinology Theme   (Gambia)

^b STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD40 LIGAND; CYTOKINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; CCL2 PROTEIN, HUMAN; CXCL10 PROTEIN, HUMAN; TUBERCULIN; TUMOR NECROSIS FACTOR; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

DISEASE CLASSIFICATION; EX VIVO STUDY; HUMAN; INFLAMMATION; INTERFERON GAMMA RELEASE ASSAY; LETTER; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLEURA FLUID; POINT OF CARE TESTING; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SPUTUM; SPUTUM ANALYSIS; TUBERCULOSIS; TUBERCULOSIS RAPID TEST; CHEMISTRY; COMMUNICABLE DISEASE CONTROL; DEVICES; DIAGNOSTIC TEST; GAMBIA; METABOLISM; PROCEDURES; REPRODUCIBILITY; TUBERCULIN TEST;

BIOMARKERS; CHEMOKINE CCL2; CHEMOKINE CXCL10; COMMUNICABLE DISEASE CONTROL; CYTOKINES; DIAGNOSTIC TESTS, ROUTINE; EPIDERMAL GROWTH FACTOR; GAMBIA; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPUTUM; TUBERCULIN; TUBERCULIN TEST; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84903841974     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00209913     Document Type: Letter

References (12)

1. World Health Organization. WHO Global Tuberculosis Report 2013. www.who.int/tb/publications/factsheet-global.pdfDatelastupdated:2013. Datelastaccessed:February28,2014.
2. Weyer K, Mirzayev F, Migliori GB, et al. Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF. Eur Respir J 2013; 42: 252-271.
3. Albanna AS, Bachmann K, White D, et al. Serum lipids biomarkers for therapeutic monitoring of latent tuberculosis infection. Eur Respir J 2013; 42: 547-550.
4. Minion J, Leung E, Talbot E, et al. Diagnosing tuberculosis with urine lipoarabinomannan: systematic review and meta-analysis. Eur Respir J 2011; 38: 1398-1405.
5. Chegou NN, Heyckendorf J, Walzl G, et al. Beyond the IFN-c horizon: biomarkers for immunodiagnosis of infection with M. tuberculosis. Eur Respir J 2014; 43: 1472-1486.
6. Sutherland JS, Garba D, Fombah AE, et al. Highly accurate diagnosis of pleural tuberculosis by immunological analysis of the pleural effusion. PLoS One 2012; 7: e30324.
7. Batz HG, Cook GS, Reid SD. Towards lab-free tuberculosis diagnostics. www.msfaccess.org/sites/default/files/MSF-assets/TB/Docs/TB-Report- TowardsLabFreeTBDX-2011-ENG.pdf
8. Ribeiro-Rodrigues R, Resende Co T, Johnson JL, et al. Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance. Clin Diagn Lab Immunol 2002; 9: 818-823.
9. Yang CT, Cambier CJ, Davis JM, et al. Neutrophils exert protection in the early tuberculosis granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe 2012; 12: 301-312.
10. Cormican LJ, Schey S, Milburn HJ. G-CSF enables completion of tuberculosis therapy associated with iatrogenic neutropenia. Eur Respir J 2004; 23: 649-650.
11. M.ariotti S, Sargentini V, Pardini M, et al. Mycobacterium tuberculosis may escape helper T cell recognition by infecting human fibroblasts. Hum Immunol 2013; 74: 722-729.
12. Diel R, Loddenkemper R, Zellweger JP, et al. Old ideas to innovate tuberculosis control: preventive treatment to achieve elimination. Eur Respir J 2013; 42: 785-801. Partnership