The protective effects of nausea and vomiting of pregnancy against adverse fetal outcome-A systematic review

Reproductive Toxicology

Volumn 47, Issue , 2014, Pages 77-80

  Koren, Gideon ^a   Madjunkova, Svetlana ^a   Maltepe, Caroline ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Congenital malformations; Miscarriage; Nausea and vomiting of pregnancy; NVP; Pregnancy outcome; Prematurity

Indexed keywords

ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; BENDECTIN; DOXYLAMINE PLUS PYRIDOXINE; MECLOZINE;

ADVERSE OUTCOME; ALLERGY; CHILD DEVELOPMENT; CONGENITAL MALFORMATION; EFFECT SIZE; FETUS OUTCOME; HUMAN; INTELLIGENCE QUOTIENT; INTRAUTERINE GROWTH RETARDATION; LOW BIRTH WEIGHT; MORNING SICKNESS; NAUSEA AND VOMITING; NAUSEA AND VOMITING OF PREGNANCY; PREGNANCY DISORDER; PREGNANT WOMAN; PREMATURITY; REVIEW; SMALL FOR DATE INFANT; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW; FEMALE; FETUS; NAUSEA; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; VOMITING; DISEASE SEVERITY; MULTIVARIATE ANALYSIS; PERINATAL DRUG EXPOSURE;

FEMALE; FETUS; HUMANS; NAUSEA; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; VOMITING;

EID: 84903836395     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.05.012     Document Type: Review

References (19)

1. Maltepe C., Koren G. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum - a 2013 update. J Popul Ther Clin Pharmacol 2013, 20:14.
2. Clark S.M., Costantine M.M., Hankins G.D. Review of NVP and HG and early pharmacotherapeutic intervention. Obstet Gynecol Int 2012, 252676:24.
3. Brandes J.M. First-trimester nausea and vomiting as related to outcome of pregnancy. Obstet Gynecol 1967, 30:427-431.
4. Chan R.L., Olshan A.F., Savitz D.A., Herring A.H., Daniels J.L., Peterson H.B., et al. Severity and duration of nausea and vomiting symptoms in pregnancy and spontaneous abortion. Hum Reprod 2010, 25:2907-2912.
5. Weigel M.M., Reyes M., Caiza M.E., Tello N., Castro N.P., Cespedes S., et al. Is the nausea and vomiting of early pregnancy really feto-protective?. J Perinat Med 2006, 34:115-122.
6. Czeizel A.E., Puho E., Acs N., Banhidy F. Inverse association between severe nausea and vomiting in pregnancy and some congenital abnormalities. Am J Med Genet A 2006, 140:453-462.
7. Asker C., Norstedt Wikner B., Kallen B. Use of antiemetic drugs during pregnancy in Sweden. Eur J Clin Pharmacol 2005, 61:899-906.
8. Kallen B., Mottet I. Delivery outcome after the use of meclozine in early pregnancy. Eur J Epidemiol 2003, 18:665-669.
9. Kallen B. Use of antihistamine drugs in early pregnancy and delivery outcome. J Matern Fetal Neonatal Med 2002, 11:146-152.
10. Seto A. The safety of antihistamines in pregnancy: a meta analysis 1992, [Master thesis], University of Toronto, Toronto. http://www.motherisk.org/documents/studies/Anti%20histamines_MetaAnalysis.pdf.
11. Anderka M., Mitchell A.A., Louik C., Werler M.M., Hernandez-Diaz S., Rasmussen S.A. Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects. Birth Defects Res A: Clin Mol Teratol 2012, 94:22-30.
12. Czeizel A.E., Puho E. Association between severe nausea and vomiting in pregnancy and lower rate of preterm births. Paediatr Perinat Epidemiol 2004, 18:253-259.
13. Nulman I., Rovet J., Barrera M., Knittel-Keren D., Feldman B.M., Koren G. Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin. J Pediatr 2009, 155:45-50.
14. Koren G., Boskovic R., Hard M., Maltepe C., Navioz Y., Einarson A. Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy. Am J Obstet Gynecol 2002, 186:S228-S231.
15. Mazzotta P., Stewart D., Atanackovic G., Koren G., Magee L.A. Psychosocial morbidity among women with nausea and vomiting of pregnancy: prevalence and association with anti-emetic therapy. J Psychosom Obstet Gynaecol 2000, 21:129-136.
16. Kjaersgaard M.I., Parner E.T., Vestergaard M., Sorensen M.J., Olsen J., Christensen J., et al. Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study. PLoS ONE 2013, 8:1-16.
17. Gentile S. Pregnancy exposure to serotonin reuptake inhibitors and the risk of spontaneous abortions. CNS Spectr 2008, 13:960-966.
18. Edwards D.R., Aldridge T., Baird D.D., Funk M.J., Savitz D.A., Hartmann K.E. Periconceptional over-the-counter nonsteroidal anti-inflammatory drug exposure and risk for spontaneous abortion. Obstet Gynecol 2012, 120:113-122.
19. Nakhai-Pour H.R., Broy P., Sheehy O., Berard A. Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion. CMAJ 2011, 183:1713-1720.