Genome-wide analysis of the regulatory function mediated by the small regulatory psm-mec RNA of methicillin-resistant Staphylococcus aureus

International Journal of Medical Microbiology

Volumn 304, Issue 5-6, 2014, Pages 637-644

  Cheung, Gordon Y C ^a   Villaruz, Amer E ^a   Joo, Hwang Soo ^a   Duong, Anthony C ^a   Yeh, Anthony J ^a   Nguyen, Thuan H ^a   Sturdevant, Daniel E ^b   Queck, S Y ^a,c   Otto, M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Biomerieux Singapore Pte Ltd   (Singapore)

Author keywords

Antibiotic resistance; MRSA; Staphylococcus aureus; Virulence

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; CYTOLYSIN; FACTOR PROTEIN A; PENICILLIN BINDING PROTEIN 2A; PHENOL SOLUBLE MODULIN MEC RNA; UNCLASSIFIED DRUG; BACTERIAL TOXIN; MECA PROTEIN, STAPHYLOCOCCUS AUREUS; SMALL INTERFERING RNA; STAPHYLOCOCCAL DELTA TOXIN; STAPHYLOCOCCUS PROTEIN A;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BASE PAIRING; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE LOCUS; GENE MUTATION; IMMUNE EVASION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROARRAY ANALYSIS; PENICILLIN RESISTANCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATOR GENE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; STAPHYLOCOCCUS INFECTION;

BACTERIAL PROTEINS; BACTERIAL TOXINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; RNA, SMALL INTERFERING; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCAL PROTEIN A;

EID: 84903821001     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2014.04.008     Document Type: Article

References (30)

1. Argaman L., Hershberg R., Vogel J., Bejerano G., Wagner E.G., Margalit H., Altuvia S. Novel small RNA-encoding genes in the intergenic regions of Escherichia coli. Curr. Biol. 2001, 11:941-950.
2. Bae T., Schneewind O. Allelic replacement in Staphylococcus aureus with inducible counter-selection. Plasmid 2006, 55:58-63.
3. Chatterjee S.S., Chen L., Joo H.S., Cheung G.Y., Kreiswirth B.N., Otto M. Distribution and regulation of the mobile genetic element-encoded phenol-soluble modulin PSM-mec in methicillin-resistant Staphylococcus aureus. PLoS ONE 2011, 6:e28781.
4. Cheung G.Y., Rigby K., Wang R., Queck S.Y., Braughton K.R., Whitney A.R., Teintze M., DeLeo F.R., Otto M. Staphylococcus epidermidis strategies to avoid killing by human neutrophils. PLoS Pathog. 2010, 6:e1001133.
5. Cheung G.Y., Wang R., Khan B.A., Sturdevant D.E., Otto M. Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infect. Immun. 2011, 79:1927-1935.
6. DeLeo F.R., Kennedy A.D., Chen L., Bubeck Wardenburg J., Kobayashi S.D., Mathema B., Braughton K.R., Whitney A.R., Villaruz A.E., Martens C.A., Porcella S.F., McGavin M.J., Otto M., Musser J.M., Kreiswirth B.N. Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:18091-18096.
7. Fitzgerald J.R., Sturdevant D.E., Mackie S.M., Gill S.R., Musser J.M. Evolutionary genomics of Staphylococcus aureus: insights into the origin of methicillin-resistant strains and the toxic shock syndrome epidemic. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:8821-8826.
8. Forsgren A., Nordstrom K. Protein A from Staphylococcus aureus: the biological significance of its reaction with IgG. Ann. N. Y. Acad. Sci. 1974, 236:252-266.
9. Gao J., Stewart G.C. Regulatory elements of the Staphylococcus aureus protein A (Spa) promoter. J. Bacteriol. 2004, 186:3738-3748.
10. Gomez M.I., Lee A., Reddy B., Muir A., Soong G., Pitt A., Cheung A., Prince A. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat. Med. 2004, 10:842-848.
11. Hiramatsu K., Cui L., Kuroda M., Ito T. The emergence and evolution of methicillin-resistant Staphylococcus aureus. Trends Microbiol. 2001, 9:486-493.
12. Holden M.T., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:9786-9791.
13. Kaito C., Omae Y., Matsumoto Y., Nagata M., Yamaguchi H., Aoto T., Ito T., Hiramatsu K., Sekimizu K. A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus. PLoS ONE 2008, 3:e3921.
14. Kaito C., Saito Y., Ikuo M., Omae Y., Mao H., Nagano G., Fujiyuki T., Numata S., Han X., Obata K., Hasegawa S., Yamaguchi H., Inokuchi K., Ito T., Hiramatsu K., Sekimizu K. Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence. PLoS Pathog. 2013, 9:e1003269.
15. Kaito C., Saito Y., Nagano G., Ikuo M., Omae Y., Hanada Y., Han X., Kuwahara-Arai K., Hishinuma T., Baba T., Ito T., Hiramatsu K., Sekimizu K. Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence. PLoS Pathog. 2011, 7:e1001267.
16. Kopke A.K., Leggatt P.A. Initiation of translation at an AUA codon for an archaebacterial protein gene expressed in E. coli. Nucleic Acids Res. 1991, 19:5169-5172.
17. Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y., Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Whole genome sequencing of methicillin-resistant Staphylococcus aureus. Lancet 2001, 357:1225-1240.
18. Lin L., Ibrahim A.S., Xu X., Farber J.M., Avanesian V., Baquir B., Fu Y., French S.W., Edwards J.E., Spellberg B. Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog. 2009, 5:e1000703.
19. Lowy F.D. Staphylococcus aureus infections. N. Engl. J. Med. 1998, 339:520-532.
20. Lowy F.D. Antimicrobial resistance: the example of Staphylococcus aureus. J. Clin. Invest. 2003, 111:1265-1273.
21. Merino N., Toledo-Arana A., Vergara-Irigaray M., Valle J., Solano C., Calvo E., Lopez J.A., Foster T.J., Penades J.R., Lasa I. Protein A-mediated multicellular behavior in Staphylococcus aureus. J. Bacteriol. 2009, 191:832-843.
22. Musser J.M., Kapur V. Clonal analysis of methicillin-resistant Staphylococcus aureus strains from intercontinental sources: association of the mec gene with divergent phylogenetic lineages implies dissemination by horizontal transfer and recombination. J. Clin. Microbiol. 1992, 30:2058-2063.
23. Novick R.P., Ross H.F., Projan S.J., Kornblum J., Kreiswirth B., Moghazeh S. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J. 1993, 12:3967-3975.
24. Otto M. Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu. Rev. Microbiol. 2010, 64:143-162.
25. Otto M. Staphylococcus aureus toxin gene hitchhikes on a transferable antibiotic resistance element. Virulence 2010, 1:49-51.
26. Queck S.Y., Jameson-Lee M., Villaruz A.E., Bach T.H., Khan B.A., Sturdevant D.E., Ricklefs S.M., Li M., Otto M. RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol. Cell 2008, 32:150-158.
27. Queck S.Y., Khan B.A., Wang R., Bach T.H., Kretschmer D., Chen L., Kreiswirth B.N., Peschel A., Deleo F.R., Otto M. Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog. 2009, 5:e1000533.
28. Rudkin J.K., Edwards A.M., Bowden M.G., Brown E.L., Pozzi C., Waters E.M., Chan W.C., Williams P., O'Gara J.P., Massey R.C. Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system. J. Infect. Dis. 2012, 205:798-806.
29. Wadler C.S., Vanderpool C.K. A dual function for a bacterial small RNA: SgrS performs base pairing-dependent regulation and encodes a functional polypeptide. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:20454-20459.
30. Wang R., Braughton K.R., Kretschmer D., Bach T.H., Queck S.Y., Li M., Kennedy A.D., Dorward D.W., Klebanoff S.J., Peschel A., DeLeo F.R., Otto M. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat. Med. 2007, 13:1510-1514.