-
1
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
Teglund S, Toftgard R (2010) Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 1805:181-208
-
(2010)
Biochim Biophys Acta
, vol.1805
, pp. 181-208
-
-
Teglund, S.1
Toftgard, R.2
-
2
-
-
0345059765
-
Hedgehog signalling in cancer formation and maintenance
-
Pasca di Magliano M, Hebrok M (2003) Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 3:903-911
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 903-911
-
-
Pasca Di Magliano, M.1
Hebrok, M.2
-
4
-
-
67650289584
-
Mechanisms of hedgehog pathway activation in cancer and implications for therapy
-
Scales SJ, de Sauvage FJ (2009) Mechanisms of hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 30:303-312
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
De Sauvage, F.J.2
-
5
-
-
77956292749
-
Discovery of NVPLDE225, a potent and selective smoothened antagonist
-
Pan S, Wu X, Jiang J, Gao W, Wan Y, Cheng D, Han D, Liu J, Englund NP, Wang Y, Peukert S, Miller-Moslin K, Yuan J, Guo R, Matsumoto M, Vattay A, Jiang Y, Tsao J, Sun F, Pferdekamper AMC, Dodd S, Tuntland T, Maniara W, Kelleher JF III, Yao Y-M, Warmuth M, Williams J, Dorsch M (2010) Discovery of NVPLDE225, a potent and selective smoothened antagonist. ACS Med Chem Lett 1:130-134
-
(2010)
ACS Med Chem Lett
, vol.1
, pp. 130-134
-
-
Pan, S.1
Wu, X.2
Jiang, J.3
Gao, W.4
Wan, Y.5
Cheng, D.6
Han, D.7
Liu, J.8
Englund, N.P.9
Wang, Y.10
Peukert, S.11
Miller-Moslin, K.12
Yuan, J.13
Guo, R.14
Matsumoto, M.15
Vattay, A.16
Jiang, Y.17
Tsao, J.18
Sun, F.19
Pferdekamper, A.M.C.20
Dodd, S.21
Tuntland, T.22
Maniara, W.23
Kelleher III, J.F.24
Yao, Y.-M.25
Warmuth, M.26
Williams, J.27
Dorsch, M.28
more..
-
6
-
-
77958060845
-
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
-
Buonamici S, Williams J, Morrissey M, Wang A, Guo R, Vattay A, Hsiao K, Yuan J, Green J, Ospina B, Yu Q, Ostrom L, Fordjour P, Anderson DL, Monahan JE, Kelleher JF, Peukert S, Pan S, Wu X, Maira SM, Garcia-Echeverria C, Briggs KJ, Watkins DN, Yao YM, Lengauer C, Warmuth M, Sellers WR, Dorsch M (2010) Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2:51ra70
-
(2010)
Sci Transl Med
, vol.2
-
-
Buonamici, S.1
Williams, J.2
Morrissey, M.3
Wang, A.4
Guo, R.5
Vattay, A.6
Hsiao, K.7
Yuan, J.8
Green, J.9
Ospina, B.10
Yu, Q.11
Ostrom, L.12
Fordjour, P.13
Anderson, D.L.14
Monahan, J.E.15
Kelleher, J.F.16
Peukert, S.17
Pan, S.18
Wu, X.19
Maira, S.M.20
Garcia-Echeverria, C.21
Briggs, K.J.22
Watkins, D.N.23
Yao, Y.M.24
Lengauer, C.25
Warmuth, M.26
Sellers, W.R.27
Dorsch, M.28
more..
-
7
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
DOI 10.1101/gad.1025302
-
Chen JK, Taipale J, Cooper MK, Beachy PA (2002) Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev 16:2743-2748 (Pubitemid 35253140)
-
(2002)
Genes and Development
, vol.16
, Issue.21
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
8
-
-
84898721363
-
A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor sonidegib (LDE225) in patients with advanced solid tumors
-
Rodon J, Tawbi HA, Thomas AL, Stoller RG, Turtschi CP, Baselga J, Sarantopoulos J, Mahalingham D, Shou Y, Moles MA, Yang L, Granvil C, Hurh E, Rose KL, Amakye DD, Dummer R, Mita AC (2014) A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor sonidegib (LDE225) in patients with advanced solid tumors. Clin Cancer Res 20:1900-1909
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1900-1909
-
-
Rodon, J.1
Tawbi, H.A.2
Thomas, A.L.3
Stoller, R.G.4
Turtschi, C.P.5
Baselga, J.6
Sarantopoulos, J.7
Mahalingham, D.8
Shou, Y.9
Moles, M.A.10
Yang, L.11
Granvil, C.12
Hurh, E.13
Rose, K.L.14
Amakye, D.D.15
Dummer, R.16
Mita, A.C.17
-
9
-
-
40949104442
-
The 2007 recommendations of the International Commission on Radiological Protection. ICRP Publication 103
-
International Commission on Radiological Protection (ICRP)
-
International Commission on Radiological Protection (ICRP) (2007) The 2007 recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann ICRP 37(2-4):116-117
-
(2007)
Ann ICRP
, vol.37
, Issue.2-4
, pp. 116-117
-
-
-
10
-
-
48249097413
-
Performance evaluation of the new AMS system at Accium Biosciences
-
Zoppi U, Crye J, Song Q, Arjomand A (2007) Performance evaluation of the new AMS system at Accium Biosciences. Radiocarbon 49:171-180
-
(2007)
Radiocarbon
, vol.49
, pp. 171-180
-
-
Zoppi, U.1
Crye, J.2
Song, Q.3
Arjomand, A.4
-
11
-
-
0034281129
-
Accelerator mass spectrometry in pharmaceutical research and development - A new ultrasensitive analytical method for isotope measurement
-
Garner RC (2000) Accelerator mass spectrometry in pharmaceutical research and development - a new ultrasensitive analytical method for isotope measurement. Curr Drug Metab 1:205-213
-
(2000)
Curr Drug Metab
, vol.1
, pp. 205-213
-
-
Garner, R.C.1
-
14
-
-
0021707968
-
Properties of acyl glucuronides: Implications for studies of the pharmacokinetics and metabolism of acidic drugs
-
Faed EM (1984) Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs. Drug Metab Rev 15:1213-1249
-
(1984)
Drug Metab Rev
, vol.15
, pp. 1213-1249
-
-
Faed, E.M.1
-
15
-
-
0037306174
-
Acyl glucuronide drug metabolites: Toxicological and analytical implications
-
DOI 10.1097/00007691-200302000-00001
-
Shipkova M, Armstrong VW, Oellerich M, Wieland E (2003) Acyl glucuronide drug metabolites: toxicological and analytical implications. Ther Drug Monit 25:1-16 (Pubitemid 36139819)
-
(2003)
Therapeutic Drug Monitoring
, vol.25
, Issue.1
, pp. 1-16
-
-
Shipkova, M.1
Armstrong, V.W.2
Oellerich, M.3
Wieland, E.4
-
16
-
-
0027199712
-
Predictability of the covalent binding of acidic drugs in man
-
Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET (1993) Predictability of the covalent binding of acidic drugs in man. Life Sci 53:PL141-PL146
-
(1993)
Life Sci
, vol.53
-
-
Benet, L.Z.1
Spahn-Langguth, H.2
Iwakawa, S.3
Volland, C.4
Mizuma, T.5
Mayer, S.6
Mutschler, E.7
Lin, E.T.8
-
17
-
-
0036206773
-
Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin
-
DOI 10.1124/dmd.30.4.404
-
Bolze S, Bromet N, Gay-Feutry C, Massiere F, Boulieu R, Hulot T (2002) Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin. Drug Metab Dispos 30:404-413 (Pubitemid 34263825)
-
(2002)
Drug Metabolism and Disposition
, vol.30
, Issue.4
, pp. 404-413
-
-
Bolze, S.1
Bromet, N.2
Gay-Feutry, C.3
Massiere, F.4
Boulieu, R.5
Hulot, T.6
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