Cytomegalovirus alpha-chemokine genotypes are associated with clinical manifestations in children with congenital or postnatal infections

Virology

Volumn 462-463, Issue 1, 2014, Pages 207-217

  Paradowska, Edyta ^a   Jabłońska, Agnieszka ^a   Płóciennikowska, Agnieszka ^a,d   Studzińska, Mirosława ^a   Suski, Patrycja ^a   Wiśniewska Ligier, Małgorzata ^b   Dzierzanowska Fangrat, Katarzyna ^c   Kasztelewicz, Beata ^c   Woźniakowska Gesicka, Teresa ^b   Leśnikowski, Zbigniew J ^a  

^a INSTITUTE OF MEDICAL BIOLOGY   (Poland)

^b POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

^c CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^d NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Congenital infection; Human cytomegalovirus; Postnatal infection; Virus genotype; chemokine

Indexed keywords

CXCL1 CHEMOKINE; CXCL2 CHEMOKINE;

ADULT; ANEMIA; ARTICLE; BRAIN CALCIFICATION; BRAIN DYSFUNCTION; BRAIN VENTRICLE DILATATION; CONGENITAL HEART DISEASE; CONGENITAL INFECTION; CONTROLLED STUDY; CYST; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; EYE DISEASE; GENE SEQUENCE; GENOTYPE; HEARING IMPAIRMENT; HEPATOMEGALY; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; INFANT; INTRAUTERINE GROWTH RETARDATION; JAUNDICE; LIVER INJURY; MAJOR CLINICAL STUDY; MICROCEPHALY; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PETECHIA; PNEUMONIA; PREVALENCE; PRIORITY JOURNAL; PSYCHOMOTOR RETARDATION; PUERPERAL INFECTION; SPLENOMEGALY; THROMBOCYTOPENIA; UL146 GENE; UL147 GENE; VIRURIA; VIRUS GENE; VIRUS INFECTION; VIRUS LOAD;

CONGENITAL INFECTION; HUMAN CYTOMEGALOVIRUS; POSTNATAL INFECTION; VIRUS GENOTYPE; Α-CHEMOKINE;

ADULT; CHEMOKINES, CXC; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GENETIC VARIATION; GENOTYPE; GLYCOPROTEINS; HUMANS; INFANT; INFANT, NEWBORN; MALE; VIRAL ENVELOPE PROTEINS; VIRAL LOAD; VIRAL PROTEINS;

EID: 84903779294     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.06.020     Document Type: Article

References (45)

1. Aguayo F., Murayama T., Eizuru Y. UL146 variability among clinical isolates of human cytomegalovirus from Japan. Biol. Res. 2010, 43:475-480. (doi: /S0716-97602010000400013).
2. Akter P., Cunningham C., McSharry B.P., Dolan A., Addison C., Dargan D.J., Hassan-Walker A.F., Emery V.C., Griffiths P.D., Wilkinson G.W., Davison A.J. Two novel spliced genes in human cytomegalovirus. J. Gen. Virol. 2003, 84:1117-1122.
3. Arav-Boger R., Zong J.C., Foster C.B. Loss of linkage disequilibrium and accelerated protein divergence in duplicated cytomegalovirus chemokine genes. Virus Genes 2005, 31:65-72.
4. Arav-Boger R., Foster C.B., Zong J.C., Pass R.F. Human cytomegalovirus encoded α-chemokines exhibit high seguence variability in congenitally infected newborns. J. Infect. Dis. 2006, 193:788-791.
5. Arav-Boger R., Battaglia C.A., Lazzarotto T., Gabrielli L., Zong J.C., Hayward G.S., Diener-West M., Landini M.P. Cytomegalovirus (CMV)-encoded UL144 (truncated tumor necrosis factor receptor) and outcome of congenital CMV infection. J. Infect. Dis. 2006, 194:464-473.
6. Baggiolini M., Dewald B., Moser B. Human chemokines, un update. Annu. Rev. Immunol. 1997, 15:675-705.
7. Barbi M., Binda S., Caroppo S., Primache V., Didò P., Guidotti P., Corbetta C., Melotti D. CMV gB genotypes and outcome of vertical transmission: study on dried blood spots of congenitally infected babies. J. Clin. Virol. 2001, 21:75-79.
8. Boppana S.B., Fowler K.B., Pass R.F., Rivera L.B., Bradford R.D., Lakeman F.D., Britt W.J. Congenital cytomegalovirus infection, association between virus burden in infancy and hearing loss. J. Pediatr. 2005, 146:817-823.
9. Bradley A.J., Kovács I.J., Gatherer D., Dargan D.J., Alkharsah K.R., Chan P.K., Carman W.F., Dedicoat M., Emery V.C., Geddes C.C., Gerna G., Ben-Ismaeil B., Kaye S., McGregor A., Moss P.A., Pusztai R., Rawlinson W.D., Scott G.M., Wilkinson G.W., Schulz T.F., Davison A.J. Genotypic analysis of two hypervariable human cytomegalovirus genes. J. Med. Virol. 2008, 80:1615-1623. 10.1002/jmv.21241.
10. Bradley A.J., Lurain N.S., Ghazal P., Trivedi U., Cunningham C., Baluchova K., Gatherer D., Wilkinson G.W., Dargan D.J., Davison A.J. High-throughput sequence analysis of variants of human cytomegalovirus strains Towne and AD169. J. Gen. Virol. 2009, 90:2375-2380. 10.1099/vir.0.013250-0.
11. Cannon M.J., Hyde T.B., Schmid D.S. Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection. Rev. Med. Virol. 2011, 21:240-255. 10.1002/rmv.695.
12. Cha T.A., Tom E., Kemble G.W., Duke G.M., Mocarski E.S., Spaete R.R. Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains. J. Virol. 1996, 70:78-83.
13. Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L., Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C., Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W., Davison A.J. Genetic content of wild-type human cytomegalovirus. J. Gen. Virol. 2004, 85:1301-1312.
14. Dollard S.C., Grosse S.D., Ross D.S. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev. Med. Virol. 2007, 17:355-363.
15. Guerra B., Lazzarotto T., Quarta S., Lanari M., Bovicelli L., Nicolosi A., Landini M.P. Prenatal diagnosis of symptomatic congenital cytomegalovirus infection. Am. J. Obstet. Gynecol. 2000, 183:476-482.
16. long as BACs and site-directed mutagenesis using a PCR-based technique. Virology 2003, 307:164-177.
17. Hassan-Walker A.F., Mattes F.M., Griffiths P.D., Emery V.C. Quantity of cytomegalovirus DNA in different leukocyte populations during active infection in vivo and the presence of gB and UL18 transcripts. J. Med. Virol. 2001, 64:283-289.
18. Hassan-Walker A.F., Okwuadi S., Lee L., Griffiths P.D., Emery V.C. Sequence variability of the α-chemokine UL146 from clinical strains of human cytomegalovirus. J. Med. Virol. 2004, 74:573-579.
19. He R., Ruan Q., Qi Y., Ma Y.P., Huang Y.J., Sun Z.R., Ji Y.H. Sequence variability of human cytomegalovirus UL146 and UL147 genes in low-passage clinical isolates. Intervirology 2006, 49:215-223.
20. He R., Ma Y., Qi Y., Jiang S., Wang N., Li M., Ji Y., Sun Z., Ruan Q. Characterization of human cytomegalovirus UL146 transcripts. Virus Res. 2012, 163:223-228. 10.1016/j.virusres.2011.09.034.
21. Heo J., Petheram S., Demmier G., Murph J.R., Adler S.P., Bale J., Sparer T.E. Polymorphism within human cytomegalovirus chemokine (UL146/UL147) and cytokine receptor genes (UL144) are not predictive of sequelae in congenitally infected children. Virology 2008, 378:86-96. 10.1016/j.virol.2008.05.002.
22. Kenneson A., Cannon M.J. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV). Rev. Med. Virol. 2007, 17:253-276.
23. Lurain N.S., Fox A.M., Lichy H.M., Bhorade S.M., Ware C.F., Huang D.D., Kwan S.-P., Garrity E.R., Chou S. Analysis of the human cytomeaglovirus genomic region from UL146 through UL147A reveals sequence hypervariability, genotypic stability and overlapping transcripts. Virol. J. 2006, 3:4.
24. Lüttichau H.R. The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist. J. Biol. Chem. 2010, 285:9137-9146. 10.1074/jbc.M109.002774.
25. Mocarski E.S. Immunomodulation by cytomegaloviruses, manipulative strategies beyond evasion. Trends Microbiol. 2002, 10:332-339.
26. Nijman J., van Loon A.M., de Vries L.S., Koopman-Esseboom C., Groenendaal F., Uiterwaal C.S., Verboon-Maciolek M.A. Urine viral load and correlation with disease severity in infants with congenital or postnatal cytomegalovirus infection. J. Clin. Virol. 2012, 54:121-124. 10.1016/j.jcv.2012.02.017.
27. Paradowska E., Przepiórkiewicz M., Nowakowska D., Studzińska M., Wilczyński J., Emery V.C., Leśnikowski Z.J. Detection of cytomegalovirus in human placental cells by polymerase chain reaction. Acta Pathol. Microbiol. Immunol. Scand. 2006, 114:764-771.
28. Paradowska E., Studzińska M., Nowakowska D., Wilczyński J., Rycel M., Suski P., Gaj Z., Kaczmarek B., Zbróg Z., Leśnikowski Z.J. Distribution of UL144, US28 and UL55 genotypes in Polish newborns with congenital cytomegalovirus infections. Eur. J. Clin. Microbiol. Infect. Dis. 2012, 31:1335-1345. 10.1007/s10096-011-1447-z.
29. Paradowska E., Jabłońska A., Studzińska M., Suski P., Kasztelewicz B., Zawilińska B., Wiśniewska-Ligier M., Dzierżanowska-Fangrat K., Woźniakowska-Gesicka T., Czech-Kowalska J., Lipka B., Kornacka M., Pawlik D., Tomasik T., Kosz-Vnenchak M., Leśnikowski Z.J. Distribution of cytomegalovirus gN variants and associated clinical sequelae in infants. J. Clin. Virol. 2013, 58:271-275. 10.1016/j.jcv.2013.05.024.
30. Paradowska E., Jabłońska A., Studzińska M., Kasztelewicz B., Zawilińska B., Wiśniewska-Ligier M., Dzierżanowska-Fangrat K., Woźniakowska-Gesicka T., Kosz-Vnenchak M., Leśnikowski Z.J. Cytomegalovirus glycoprotein H genotype distribution and the relationship with hearing loss in children. J. Med. Virol. 2014, 86:1421-1427. http://dx.doi.org/10.1002/jmv.23906.
31. Pati S.K., Pinninti S., Novak Z., Chowdhury N., Patro R.K., Fowler K., Ross S., Boppana S. Genotypic diversity and mixed infection in newborn disease and hearing loss in congenital cytomegalovirus infection. Pediatr. Infect. Dis. J. 2013, 32:1050-1054. NIDCD CHIMES Study Investigators. 10.1097/INF.0b013e31829bb0b9.
32. Penfold M.E., Dairaghi D.J., Duke G.M., Saederup N., Mocarski E.S., Kemble G.W., Shall T.J. Cytomegalovirus encodes a potent α-chemokine. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:9839-9844.
33. Picone O., Costa J.M., Chaix M.L., Ville Y., Rouzioux C., Leruez-Ville M. Human cytomegalovirus UL144 gene polymorphisms in congenital infections. J. Clin. Microbiol. 2005, 43:25-29.
34. Pignatelli S., Dal Monte P., Rossini G., Landini M.P. Genetic polymorphisms among human cytomegalovirus (HCMV) wild-type strains. Rev. Med. Virol. 2004, 14:383-410.
35. Pignatelli S., Lazzarotto T., Gatto M.R., Dal Monte P., Landini M.P., Faldella G., Lanari M. Cytomegalovirus gN genotypes distribution among congenitally infected newborns and their relationship with symptoms at birth and sequelae. Clin. Infect. Dis. 2010, 1:33-41. 10.1086/653423.
36. Plotkin S.A., Starr S.E., Friedman H.M., Gönczöl E., Weibel R.E. Protective effects of Towne cytomegalovirus vaccine against low-passage cytomegalovirus administered as a challenge. J. Infect. Dis. 1989, 159:860-865.
37. Prichard M.N., Penfold M.E., Duke G.M., Spaete R.R., Kemble G.W. A review of genetic differences between limited and extensively passaged human cytomegalovirus strains. Rev. Med. Virol. 2001, 11:191-200.
38. Renzette N., Bhattacharjee B., Jensen J.D., Gibson L., Kowalik T.F. Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants. PLoS Pathog. 2011, 7:e1001344. 10.1371/journal.ppat.1001344.
39. Ross S.A., Novak Z., Pati S., Patro R.K., Blumenthal J., Danthuluri V.R., Ahmed A., Michaels M.G., Sánchez P.J., Bernstein D.I., Tolan R.W., Palmer A.L., Britt W.J., Fowler K.B., Boppana S.B. Mixed infection and strain diversity in congenital cytomegalovirus infection. J. Infect. Dis. 2011, 204:1003-1007. 10.1093/infdis/jir457.
40. Spector S.A., Hsia K., Crager M., Pilcher M., Cabral S., Stempien M.J. Cytomegalovirus (CMV) DNA load is an independent predictor of CMV disease and survival in advanced AIDS. J. Virol. 1999, 73:7027-7030.
41. Stagno S., Pass R.F., Dworsky M.E., Henderson R.E., Moore E.G., Walton P.D., Alford C.A. Congenital cytomegalovirus infection, the relative importance of primary and recurrent maternal infection. N. Engl. J. Med. 1982, 306:945-949.
42. Stanton R., Westmoreland D., Fox J.D., Davison A.J., Wilkinson G.W. Stability of human cytomegalovirus genotypes in persistently infected renal transplant recipients. J. Med. Virol. 2005, 75:42-46.
43. Strieter R.M., Burdick M.D., Gomperts B.N., Belperio J.A., Keane M.P. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev. 2005, 16:593-609.
44. Temperton N.J., Quenelle D.C., Lawson K.M., Zuckerman J.N., Kern E.R., Griffiths P.D., Emery V.C. Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine, adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides. J. Med. Virol. 2003, 70:86-90.
45. Waters A., Hassan J., deGascun C., Kissoon G., Knowles S., Molloy E., Connell J., Hall W.W. Human cytomegalovirus UL144 is associated with viremia and infant development sequelae in congenital infection. J. Clin. Microbiol. 2010, 48:3956-3962. 10.1128/JCM.01133-10.