Modelling three-dimensional protein structures for applications in drug design

Drug Discovery Today

Volumn 19, Issue 7, 2014, Pages 890-897

  Schmidt, Tobias ^a,b   Bergner, Andreas ^a,b,c   Schwede, Torsten ^a,b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOCHROME P450; CYTOCHROME P450 2D6; DNA METHYLTRANSFERASE; G PROTEIN COUPLED RECEPTOR; HISTONE DEACETYLASE; LIGAND; MULTIDRUG RESISTANCE PROTEIN 1; POTASSIUM CHANNEL HERG; PROTEIN; SIRTUIN;

ACCURACY; AMINO ACID SEQUENCE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG SCREENING; ENZYME SUBSTRATE; HUMAN; LIGAND BINDING; MODEL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; QUALITY CONTROL; RELIABILITY; REVIEW; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE;

ANIMALS; BINDING SITES; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84903776217     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.10.027     Document Type: Review

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