Histological significance of p53 gene expression in squamous cell carcinoma of the buccal mucosa

Journal of Maxillofacial and Oral Surgery

Volumn 8, Issue 3, 2009, Pages 205-210

  Jayade, Bhushan V ^a   Bhat, Kishore ^b   Patil, B R ^a   Nayak, Ramakant ^b   Sant, Aswari ^b  

^a Karnataka Cancer Therapy and Research Institute   (India)

^b Institute of Dental Sciences and Research Centre   (India)

Author keywords

Anneroth s grade; Histology; Immunohistochemistry; Oral squamous cell carcinoma; p53

Indexed keywords

EID: 84903764111     PISSN: 09728279     EISSN: 0974942X     Source Type: Journal    
DOI: 10.1007/s12663-009-0051-6     Document Type: Article

References (19)

1. Jhonson N, Schmid S, Franeschi S, MacDonald DG, Ferlay J, Bouquot JE et al. (2005) Squamous Cell Carcinoma. In Barnes L, Eveson JW, Reichart P, Sidransky D (eds), World Health Organisation Classification of Tumors Pathology & Genetics of Head & Neck Tumors IARC Press LYON 168–175
2. Haraf DJ, Nodzenski E, Brachman D, Mick R, Montag A, Graves D, Vokes EE, Weichselbaum RR (1996) Human pappiloma virus and p53 in head and neck cancer: clinical correlates and survival. Clin Cancer Res 2(4): 755–762
3. Girod SC, Pfeiffer P, Ries J, Pape HD (1998) Proliferative activity and loss of function of tumor suppressor genes as ‘biomarkers’ in diagnosis and prognosis of benign and preneoplastic oral lesions and oral squamous cell carcinoma. Br J Oral Maxillofac Surg 36(4): 252–260
4. Nylander K, Dabelsteen E, Hall PA (2000) The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck. J Oral Pathol Med 29(9): 413–425
5. Perez-Ordonez B, Beauchemin M, Jordon RC (2006) Molecular Biology of Squamous cell Carcinoma of the Head and Neck. J Clin Pathol 59(5): 445–453
6. Gasco M, Crook T (2003) The p53 network in head and neck cancer. Oral Oncol 39(3): 222–231
7. Guimaraes DP, Hainaut P (2002) TP53: a key gene in human cancer. Biochimie 84(1): 83–93
8. de Oliveira LR, Ribeiro-Silva A, Zucoloto S (2007) Prognostic impact of p53 and p63 immunoexpression in oral squamous cell carcinoma. J Oral Pathol Med 36(4): 191–197
9. Agarwal S, Mathur M, Srivastava A, Ralhan R (1999) MDM2/p53 co-expression in oral premalignant and malignant lesions: potential prognostic implications. Oral oncol 35(2): 209–216
10. Shiraki M, Odajima T, Ikeda T, Sasaki A, Satoh M, Yamaguchi A, Noguchi M, Nagai I, Hiratsuka H (2005) Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer. Mod Pathol 18(11): 1482–1489
11. Anneroth G, Hansen LS, Silverman S Jr (1986) Malignancy grading in oral squamous cell carcinoma. I. squamous cell carcinoma of the tongue and floor of mouth: histologic grading in the clinical evaluation. J Oral Pathol 15(3): 162–168
12. Okada Y, Mataga I, Katagiri M, Ishii K (2003) An analysis of cervical lymph nodes metastasis in oral squamous cell carcinoma: relationship between grade of histopathological malignancy and lymph nodes metastasis. Int J Oral Maxillofac Surg 32(3): 284–288
13. De Araujo VC, Loyola AM, Pinto Junior DD, Borra RC, De Araujo NS (1997) p53 in biopsies of oral squamous cell carcinoma. A comparative study with a malignancy grading system. Oral Oncol 33(1): 5–9
14. Bryne M, Koppang HS, Lilleng R et.al. (1989) New Malignancy grading is a better prognostic indicator than Broder’s gradingin Oral Squamous Cell Carcinoma. J Oral Pathol Med 18(8): 432–437
15. Cruz I, Snijders PJ, Van Houten V, Vosjan M, Van der Waal I, Meijer CJ (2002) Specific p53 immunostaining patterns are associated with smoking habits in patients with oral squamous cell carcinomas. J Clin Pathol 55(11): 834–840
16. Panjwani S, Sadiq S (2008) p53 expression in benign dysplastic and malignant oral squamous epithelial lesions. Pak J Med Sci 24(1): 130–135
17. Kurokawa H, Zhang M, Matsumoto S, Yamashita Y, Tanaka T, Tomoyose T, Takano H, Funaki K, Fukuyama H, Takahashi T, Sakoda S (2005) The relationship of the histologic grade at the deep invasive front and the expression of Ki-67 antigen and p53 protein in oral squamous cell carcinoma. J Oral Pathol Med 34(10): 602–607
18. Yamazaki Y, Chiba I, Hirai A, Notani K, Kashiwazaki H, Tei K, Totsuka Y, Iizuka T, Kohgo T, Fukuda H (2003) Radioresistance in oral squamous cell carcinoma with p53 DNA contact mutation. Am J Clin Oncol 26(5): e124–129
19. Carlos de Vicente J, Junquera Gutierrez LM, Zapatero AH, Fresno Forcelledo MF, Hernandez-Vallejo G, Lopez Arranz JS (2004) Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases. Head Neck 26(1): 22–30