Inhibition of serotonin reuptake by antidepressants and cerebral microbleeds in the general population

Stroke

Volumn 45, Issue 7, 2014, Pages 1951-1957

  Aarts, Nikkie ^a   Akoudad, Saloua ^a   Noordam, Raymond ^a   Hofman, Albert ^a   Ikram, M Arfan ^a   Stricker, Bruno H ^a,b   Visser, Loes E ^a   Vernooij, Meike W ^a,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Inspectorate of Health Care   (Netherlands)

^c Apotheek Haagse Ziekenhuizen   (Netherlands)

Author keywords

antidepressive agents; cerebral small vessel diseases; serotonin

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CITALOPRAM; CLOMIPRAMINE; DESIPRAMINE; DOSULEPIN; DOXEPIN; DULOXETINE; FLUVOXAMINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMIPRAMINE; MAPROTILINE; MIANSERIN; MIRTAZAPINE; MOCLOBEMIDE; NEFAZODONE; NORTRIPTYLINE; OPIPRAMOL; PAROXETINE; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAZODONE; VENLAFAXINE;

ADULT; ARTICLE; BLOOD VESSEL INJURY; BRAIN DAMAGE; BRAIN HEMORRHAGE; CARDIOVASCULAR RISK; CENTER FOR EPIDEMIOLOGICAL STUDIES DEPRESSION SCALE; CEREBROSPINAL FLUID; CEREBROVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; DEPRESSION; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLLOW UP; GRAY MATTER; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; POPULATION; PRESCRIPTION; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; WHITE MATTER; WHITE MATTER LESION;

ANTIDEPRESSIVE AGENTS; CEREBRAL SMALL VESSEL DISEASES; SEROTONIN;

AGED; BRAIN; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; DEPRESSION; DRUG PRESCRIPTIONS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MICROVESSELS; MIDDLE AGED; NETHERLANDS; PROSPECTIVE STUDIES; RISK; SEROTONIN UPTAKE INHIBITORS;

EID: 84903761217     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.114.004990     Document Type: Article

References (52)

1. Parabiaghi A, Franchi C, Tettamanti M, Barbato A, D'Avanzo B, Fortino I, et al. Antidepressants utilization among elderly in Lombardy from 2000 to 2007: dispensing trends and appropriateness. Eur J Clin Pharmacol. 2011;67: 1077-1083.
2. Sonnenberg CM, Deeg DJ, Comijs HC, van Tilburg W, Beekman AT. Trends in antidepressant use in the older population: results from the LASA-study over a period of 10 years. J Affect Disord. 2008;111: 299-305.
3. Olfson M, Marcus SC, Pincus HA, Zito JM, Thompson JW, Zarin DA. Antidepressant prescribing practices of outpatient psychiatrists. Arch Gen Psychiatry. 1998;55: 310-316. (Pubitemid 28173620)
4. Chemali Z, Chahine LM, Fricchione G. The use of selective serotonin reuptake inhibitors in elderly patients. Harv Rev Psychiatry. 2009;17: 242-253.
5. MacGillivray S, Arroll B, Hatcher S, Ogston S, Reid I, Sullivan F, et al. Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis. BMJ. 2003;326:1014.
6. Coupland C, Dhiman P, Morriss R, Arthur A, Barton G, Hippisley-Cox J. Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ. 2011;343:d4551.
7. Lewis JD, Strom BL, Localio AR, Metz DC, Farrar JT, Weinrieb RM, et al. Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity. Pharmacoepidemiol Drug Saf. 2008;17: 328-335. (Pubitemid 351566348)
8. Gärtner R, Cronin-Fenton D, Hundborg HH, Pedersen L, Lash TL, Sørensen HT, et al. Use of selective serotonin reuptake inhibitors and risk of re-operation due to post-surgical bleeding in breast cancer patients: A Danish population-based cohort study. BMC Surg. 2010;10:3.
9. Verdel BM, Souverein PC, Meenks SD, Heerdink ER, Leufkens HG, Egberts TC. Use of serotonergic drugs and the risk of bleeding. Clin Pharmacol Ther. 2011;89: 89-96.
10. Maurer-Spurej E, Pittendreigh C, Solomons K. The influence of selective serotonin reuptake inhibitors on human platelet serotonin. Thromb Haemost. 2004;91: 119-128. (Pubitemid 38120206)
11. Bismuth-Evenzal Y, Gonopolsky Y, Gurwitz D, Iancu I, Weizman A, Rehavi M. Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs. J Affect Disord. 2012;136: 99-103.
12. Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B. Paroxetine decreases platelet serotonin storage and platelet function in human beings. Clin Pharmacol Ther. 2000;68: 435-442.
13. Padma L, Ranjani R, Rohini ST. Selective serotonin reuptake inhibitors and the risk of bleeding. Int J Basic Clin Pharmacol. 2013;2:272-274
14. Andrade C, Sandarsh S, Chethan KB, Nagesh KS. Serotonin reuptake inhibitor antidepressants and abnormal bleeding: A review for clinicians and a reconsideration of mechanisms. J Clin Psychiatry. 2010;71: 1565-1575.
15. Bak S, Tsiropoulos I, Kjaersgaard JO, Andersen M, Mellerup E, Hallas J, et al. Selective serotonin reuptake inhibitors and the risk of stroke: A population-based case-control study. Stroke. 2002;33: 1465-1473. (Pubitemid 34619941)
16. Chen Y, Guo JJ, Li H, Wulsin L, Patel NC. Risk of cerebrovascular events associated with antidepressant use in patients with depression: A population-based, nested case-control study. Ann Pharmacother. 2008;42: 177-184. (Pubitemid 351238564)
17. Chen Y, Guo JJ, Patel NC. Hemorrhagic stroke associated with antidepressant use in patients with depression: does degree of serotonin reuptake inhibition matter? Pharmacoepidemiol Drug Saf. 2009;18: 196-202.
18. de Abajo FJ, Jick H, Derby L, Jick S, Schmitz S. Intracranial haemorrhage and use of selective serotonin reuptake inhibitors. Br J Clin Pharmacol. 2000;50: 43-47. (Pubitemid 30416970)
19. Douglas I, Smeeth L, Irvine D. The use of antidepressants and the risk of haemorrhagic stroke: A nested case control study. Br J Clin Pharmacol. 2011;71: 116-120.
20. Kharofa J, Sekar P, Haverbusch M, Moomaw C, Flaherty M, Kissela B, et al. Selective serotonin reuptake inhibitors and risk of hemorrhagic stroke. Stroke. 2007;38: 3049-3051. (Pubitemid 350035702)
21. Pan A, Okereke OI, Sun Q, Logroscino G, Manson JE, Willett WC, et al. Depression and incident stroke in women. Stroke. 2011;42: 2770-2775.
22. Smoller JW, Allison M, Cochrane BB, Curb JD, Perlis RH, Robinson JG, et al. Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study. Arch Intern Med. 2009;169: 2128-2139.
23. Hackam DG, Mrkobrada M. Selective serotonin reuptake inhibitors and brain hemorrhage: A meta-analysis. Neurology. 2012;79: 1862-1865.
24. Trifirò G, Dieleman J, Sen EF, Gambassi G, Sturkenboom MC. Risk of ischemic stroke associated with antidepressant drug use in elderly persons. J Clin Psychopharmacol. 2010;30: 252-258.
25. Lee YC, Lin CH, Lin MS, Lin JW, Chang CH, Lai MS. Effects of selective serotonin reuptake inhibitors versus tricyclic antidepressants on cerebrovascular events: A nationwide population-based cohort study. J Clin Psychopharmacol. 2013;33: 782-789.
26. Charidimou A, Kakar P, Fox Z, Werring DJ. Cerebral microbleeds and recurrent stroke risk: systematic review and meta-analysis of prospective ischemic stroke and transient ischemic attack cohorts. Stroke. 2013;44: 995-1001.
27. Gregoire SM, Brown MM, Kallis C, Jäger HR, Yousry TA, Werring DJ. MRI detection of new microbleeds in patients with ischemic stroke: fiveyear cohort follow-up study. Stroke. 2010;41: 184-186.
28. Smith EE, Nandigam KR, Chen YW, Jeng J, Salat D, Halpin A, et al. MRI markers of small vessel disease in lobar and deep hemispheric intracerebral hemorrhage. Stroke. 2010;41: 1933-1938.
29. Vernooij MW, Haag MDM, van der Lugt A, Hofman A, Krestin GP, Stricker BH, et al. Use of antithrombotic drugs and the presence of cerebral microbleeds the rotterdam scan study. Arch Neurol. 2009;66:714-720
30. Darweesh SK, Leening MJ, Akoudad S, Loth DW, Hofman A, Ikram MA, et al. Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study. J Am Heart Assoc. 2013;2:e000359.
31. Wardlaw JM, Smith C, Dichgans M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol. 2013;12: 483-497.
32. Hofman A, Murad S, Duijn C, Franco O, Goedegebure A, Arfan Ikram M, et al. The rotterdam study: 2014 objectives and design update. Eur J Epidemiol. 2013:1-38
33. Ikram MA, van der Lugt A, Niessen WJ, Krestin GP, Koudstaal PJ, Hofman A, et al. The Rotterdam Scan Study: design and update up to 2012. Eur J Epidemiol. 2011;26: 811-824.
34. Meijer WE, Heerdink ER, Nolen WA, Herings RM, Leufkens HG, Egberts AC. Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants. Arch Intern Med. 2004;164: 2367-2370. (Pubitemid 39532249)
35. van Walraven C, Mamdani MM, Wells PS, Williams JI. Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study. BMJ. 2001;323: 655-658. (Pubitemid 32897004)
36. Tatsumi M, Groshan K, Blakely RD, Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997;340: 249-258. (Pubitemid 28022649)
37. Owens MJ, Knight DL, Nemeroff CB. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol Psychiatry. 2001;50: 345-350. (Pubitemid 32816947)
38. Kuo F, Gillespie TA, Kulanthaivel P, Lantz RJ, Ma TW, Nelson DL, et al. Synthesis and biological activity of some known and putative duloxetine metabolites. Bioorg Med Chem Lett. 2004;14: 3481-3486. (Pubitemid 38737151)
39. Vernooij MW, Ikram MA, Wielopolski PA, Krestin GP, Breteler MM, van der Lugt A. Cerebral microbleeds: Accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection. Radiology. 2008;248: 272-277.
40. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008;70: 1208-1214. (Pubitemid 351482572)
41. de Boer R, Vrooman HA, van der Lijn F, Vernooij MW, Ikram MA, van der Lugt A, et al. White matter lesion extension to automatic brain tissue segmentation on MRI. Neuroimage. 2009;45: 1151-1161.
42. Vrooman HA, Cocosco CA, van der Lijn F, Stokking R, Ikram MA, Vernooij MW, et al. Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification. Neuroimage. 2007;37: 71-81. (Pubitemid 47068998)
43. Poels MM, Vernooij MW, Ikram MA, Hofman A, Krestin GP, van der Lugt A, et al. Prevalence and risk factors of cerebral microbleeds: An update of the Rotterdam scan study. Stroke. 2010;41(10 suppl):S103-S106.
44. Rumsfeld JS, Ho PM. Depression and cardiovascular disease: A call for recognition. Circulation. 2005;111: 250-253. (Pubitemid 40165328)
45. Radloff LS. The ces-d scale: A self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385-401
46. Blazer D, Burchett B, Service C, George LK. The association of age and depression among the elderly: An epidemiologic exploration. J Gerontol. 1991;46:M210-M215.
47. Leening MJ, Kavousi M, Heeringa J, van Rooij FJ, Verkroost-van Heemst J, Deckers JW, et al. Methods of data collection and definitions of cardiac outcomes in the Rotterdam Study. Eur J Epidemiol. 2012;27: 173-185.
48. Soo YO, Siu DY, Abrigo J, Yu S, Ng N, Ahuja AT, et al. Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergoing endovascular intervention. Stroke. 2012;43: 1532-1536.
49. Sun S, Gao P, Sui B, Xue J, Wang H, Wang Q, et al. Association between cerebral microbleeds and the first onset of intracerebral hemorrhage - a 3.0 T MR study. Acta Radiol. 2012;53: 203-207.
50. McGrath ER, O'Donnell MJ. Estimating treatment effects in observational studies. Neurology. 2012;79: 1844-1845.
51. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*- weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol. 1999;20: 637-642. (Pubitemid 30429021)
52. Ramasubbu R. Cerebrovascular effects of selective serotonin reuptake inhibitors: A systematic review. J Clin Psychiatry. 2004;65: 1642-1653.