HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Hobbs, Charlotte V ^a   Neal, Jillian ^a   Conteh, Solomon ^a   Donnelly, Liam ^a   Chen, Jingyang ^a   Marsh, Kennan ^b   Lambert, Lynn ^a   Orr Gonzalez, Sachy ^a   Hinderer, Jessica ^a   Healy, Sara ^a   Borkowsky, William ^c   Penzak, Scott R ^a,e   Chakravarty, Sumana ^d   Hoffman, Stephen L ^d   Duffy, Patrick E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b ABBVIE INC   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SANARIA INC   (United States)

^e University of North Texas System College of Pharmacy   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOPINAVIR; RITONAVIR; SULFAMETHOXAZOLE; TRIMETHOPRIM; ANTIMALARIAL AGENT; DRUG COMBINATION; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; LOPINAVIR-RITONAVIR DRUG COMBINATION; SULFADOXINE; TRIMETHOPRIM, SULFADOXINE DRUG COMBINATION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALARIA CONTROL; MALARIA FALCIPARUM; MALE; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM KNOWLESI; RHESUS MONKEY; SINGLE DRUG DOSE; ANIMAL; DISEASE MODEL; DRUG COMBINATION; LIVER; MALARIA, FALCIPARUM; METABOLISM; PARASITOLOGY; PATHOLOGY; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; HIV PROTEASE INHIBITORS; LIVER; LOPINAVIR; MACACA MULATTA; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; RITONAVIR; SULFADOXINE; TRIMETHOPRIM;

EID: 84903759829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100138     Document Type: Article

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