Negative symptoms mediate the influence of theory of mind on functional status in schizophrenia

Social Psychiatry and Psychiatric Epidemiology

Volumn 49, Issue 7, 2014, Pages 1151-1156

  Mehta, Urvakhsh Meherwan ^a   Thirthalli, Jagadisha ^a   Naveen Kumar, Channaveerachari ^a   Kumar, J Keshav ^a   Gangadhar, Bangalore N ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Functional disability; Negative symptoms; Psychosis; Remission; Theory of mind

Indexed keywords

ADULT; ARTICLE; COGNITION; FEMALE; HUMAN; MALE; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; SCHIZOPHRENIA; SOCIAL BEHAVIOR; THEORY OF MIND;

ADULT; COGNITION; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SOCIAL BEHAVIOR; THEORY OF MIND;

EID: 84903751281     PISSN: 09337954     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00127-013-0804-x     Document Type: Article

References (36)

1. Fett AK, Viechtbauer W, Dominguez MD, Penn DL, van Os J, Krabbendam L (2011) The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 35(3):573-588
2. Foussias G, Remington G (2010) Negative symptoms in schizophrenia: avolition and Occam's razor. Schizophr Bull 36(2):359-369. doi: 10.1093/schbul/sbn094
3. Schmidt SJ, Mueller DR, Roder V (2011) Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling. Schizophr Bull 37(Suppl 2):S41-S54
4. Ventura J, Hellemann GS, Thames AD, Koellner V, Nuechterlein KH (2009) Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophr Res 113(2-3):189-199. doi: 10.1016/j.schres.2009.03.035
5. Bell MD, Corbera S, Johannesen JK, Fiszdon JM, Wexler BE (2013) Social cognitive impairments and negative symptoms in schizophrenia: are there subtypes with distinct functional correlates? Schizophr Bull 39(1):186-196. doi: 10.1093/schbul/sbr125
6. Sergi MJ, Green MF, Widmark C, Reist C, Erhart S, Braff DL, Kee KS, Marder SR, Mintz J (2007) Social cognition [corrected] and neurocognition: effects of risperidone, olanzapine, and haloperidol. Am J Psychiatry 164(10):1585-1592 (Pubitemid 350069739)
7. Lincoln TM, Mehl S, Kesting ML, Rief W (2011) Negative symptoms and social cognition: identifying targets for psychological interventions. Schizophr Bull 37(Suppl 2):S23-S32
8. Mehta UM, Thirthalli J, Naveen Kumar C, Keshav KJ, Gangadhar BN, Keshavan MS (2013) Schizophrenia patients experience substantial social cognition deficits across multiple domains in remission. Asian J Psychiatry 6(4):324-329. doi: 10.1016/j.ajp.2013.02.001
9. Couture SM, Granholm EL, Fish SC (2011) A path model investigation of neurocognition, theory of mind, social competence, negative symptoms and real-world functioning in schizophrenia. Schizophr Res 125(2-3):152-160
10. Rassovsky Y, Horan WP, Lee J, Sergi MJ, Green MF (2011) Pathways between early visual processing and functional outcome in schizophrenia. Psychol Med 41(3):487-497. doi: 10.1017/S0033291710001054
11. Green MF, Hellemann G, Horan WP, Lee J, Wynn JK (2012) From perception to functional outcome in schizophrenia: modeling the role of ability and motivation. Arch Gen Psychiatry 69(12):1216-1224. doi: 10.1001/ archgenpsychiatry.2012.652
12. Gard DE, Fisher M, Garrett C, Genevsky A, Vinogradov S (2009) Motivation and its relationship to neurocognition, social cognition, and functional outcome in schizophrenia. Schizophr Res 115(1):74-81
13. Lin CH, Huang CL, Chang YC, Chen PW, Lin CY, Tsai GE, Lane HY (2013) Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia. Schizophr Res 146(1-3):231-237. doi: 10.1016/j.schres.2013.02.009
14. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22-33 (quiz 34-57) (Pubitemid 29001829)
15. Andreasen NC, Carpenter WT Jr, Kane JM, Lasser RA, Marder SR, Weinberger DR (2005) Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry 162(3):441-449 (Pubitemid 40343909)
16. Green MF, Penn DL, Bentall R, Carpenter WT, Gaebel W, Gur RC, Kring AM, Park S, Silverstein SM, Heinssen R (2008) Social cognition in schizophrenia: an NIMH workshop on definitions, assessment, and research opportunities. Schizophr Bull 34(6):1211-1220
17. Mehta UM, Thirthalli J, Naveen Kumar C, Mahesh M, Rao K, Subbakrishna DK, Gangadhar BN, Keshavan MS (2011) Validation of Social Cognition Rating Tools in Indian Setting (SOCRATIS): a new test-battery to assess social cognition. Asian J Psychiatry 4:203-209
18. Behere RV, Raghunandan V, Venkatasubramanian G, Subbakrishna DK, Jayakumar PN, Gangadhar BN (2008) Trends - a tool for recognition of emotions in neuropsychiatric disorders. Indian J Psychol Med 30(1):32-38
19. Rao SL, Subbukrishna DK, Gopukuar K (2004) NIMHANS neuropsychology battery. NIMHANS Publications, Bangalore
20. Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, Essock S, Fenton WS, Frese FJ 3rd, Gold JM, Goldberg T, Heaton RK, Keefe RS, Kraemer H, Mesholam-Gately R, Seidman LJ, Stover E, Weinberger DR, Young AS, Zalcman S, Marder SR (2008) The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry 165(2):203-213 (Pubitemid 351704520)
21. Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L (1988) The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res 26(2):223-238
22. Wechsler D (1981) Wechsler Adult Intelligence Scale - revised manual. Psychological Corporation, New York
23. D'Elia LF, Satz P, Uchiyama CL, White T (1994) Color Trails Test professional manual. Psychological Assessment Resources, Odessa, FL
24. Rey A (1941) L'examen psychologique dans les cas d'encéphalopathie traumatique. 28(21):286-340
25. Osterrieth PA (1944) Le test de copie d'une figure complexe. Arch Psychol 30:206-356
26. Kirchner WK (1958) Age differences in short-term retention of rapidly changing information. J Exp Psychol 55(4):352-358
27. PsychologicalCorporation (1997) WAIS-III-WMS-III Technical Manual. The Psychological Corporation, San Antonio
28. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G (1993) Wisconsin Card Sorting Test manual revised and expanded. Psychological Assessment Resources, Odessa, FL
29. Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261-276 (Pubitemid 18039085)
30. Wiersma D, DeJong A, Ormel J (1988) The Groningen Social Disabilities Schedule: development, relationship with I.C.I.D.H., and psychometric properties. Int J Rehabil Res 11(3):213-224 (Pubitemid 20045857)
31. Preacher KJ, Hayes AF (2008) Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 40(3):879-891
32. MacKinnon DP, Lockwood CM, Hoffman JM, West SG, Sheets V (2002) A comparison of methods to test mediation and other intervening variable effects. Psychol Methods 7(1):83-104
33. Green MF (2006) Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry 67 Suppl 9:3-8, discussion 36-42 (Pubitemid 44369648)
34. Srinivasan L, Tirupati S (2005) Relationship between cognition and work functioning among patients with schizophrenia in an urban area of India. Psychiatric services 56(11):1423-1428. doi: 10.1176/appi.ps.56.11.1423 (Pubitemid 41579778)
35. Green MF, Nuechterlein KH, Gold JM, Barch DM, Cohen J, Essock S, Fenton WS, Frese F, Goldberg TE, Heaton RK, Keefe RS, Kern RS, Kraemer H, Stover E, Weinberger DR, Zalcman S, Marder SR (2004) Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry 56(5):301-307 (Pubitemid 39164514)
36. Santiesteban I, White S, Cook J, Gilbert SJ, Heyes C, Bird G (2012) Training social cognition: from imitation to Theory of Mind. Cognition 122(2):228-235. doi: 10.1016/j.cognition.2011.11.004