Cell cycle dependent oscillatory expression of estrogen receptor-α links Pol II elongation to neoplastic transformation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 26, 2014, Pages 9561-9566

  Vantaggiato, Cristina ^a   Tocchetti, Marta ^a   Cappelletti, Vera ^b   Gurtner, Aymone ^c   Villa, Alessandro ^a   Daidone, Maria Grazia ^b   Piaggio, Giulia ^c   Maggi, Adriana ^a   Ciana, Paolo ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Genetic polymorphisms; Oscillatory gene expression; Polymerase blockage; Steroid receptors; Transcriptional oscillators

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ONCOPROTEIN; PROTEIN C MYB; PVUII PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG; XBAI PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER RISK; CARCINOGENESIS; CELL CYCLE; CELL CYCLE PHASE; CELL ELONGATION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; INTRON; MITOGENESIS; ONCOGENE C MYB; OSCILLATION; OSCILLATOR; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN SECRETION; PROTO ONCOGENE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

GENETIC POLYMORPHISMS; OSCILLATORY GENE EXPRESSION; POLYMERASE BLOCKAGE; STEROID RECEPTORS; TRANSCRIPTIONAL OSCILLATORS;

ANALYSIS OF VARIANCE; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; MCF-7 CELLS; PLASMIDS; POLYMORPHISM, SINGLE NUCLEOTIDE; REAL-TIME POLYMERASE CHAIN REACTION; RNA POLYMERASE II;

EID: 84903742351     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321750111     Document Type: Article

References (39)

1. Hill SM, Fuqua SAW, Chamness GC, Greene GL, McGuire WL (1989) Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism. Cancer Res 49(1):145-148.
2. Boyapati SM, et al. (2005) Polymorphisms in ER-α gene interact with estrogen receptor status in breast cancer survival. Clin Cancer Res 11(3):1093-1098.
3. Ryan J, et al. (2012) Hormone treatment, estrogen receptor polymorphisms and mortality: A prospective cohort study. PLoS ONE 7(3):e34112.
4. Wedrén S, et al. (2004) Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: A case control study. Breast Cancer Res 6(4):R437-R449.
5. Parl FF, Cavener DR, Dupont WD (1989) Genomic DNA analysis of the estrogen receptor gene in breast cancer. Breast Cancer Res Treat 14(1):57-64.
6. Andersen TI, et al. (1994) Oestrogen receptor (ESR) polymorphisms and breast cancer susceptibility. Hum Genet 94(6):665-670.
7. Cai Q, et al. (2003) Genetic polymorphisms in the estrogen receptor α gene and risk of breast cancer: Results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 12(9):853-859.
8. van Duijnhoven FJ, et al. (2005) Polymorphisms in the estrogen receptor α gene and mammographic density. Cancer Epidemiol Biomarkers Prev 14(11 Pt 1):2655-2660.
9. Weel AE, et al. (1999) Estrogen receptor polymorphism predicts the onset of natural and surgical menopause. J Clin Endocrinol Metab 84(9):3146-3150.
10. Weiderpass E, et al. (2000) Estrogen receptor α gene polymorphisms and endometrial cancer risk. Carcinogenesis 21(4):623-627.
11. Suzuki K, et al. (2003) Genetic polymorphisms of estrogen receptor alpha, CYP19, catechol-O-methyltransferase are associated with familial prostate carcinoma risk in a Japanese population. Cancer 98(7):1411-1416.
12. Herrington DM, et al. (2002) Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation 105(16):1879-1882.
13. Yaich L, Dupont WD, Cavener DR, Parl FF (1992) Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Res 52(1):77-83.
14. Maruyama H, et al. (2000) Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease. Arch Neurol 57(2): 236-240.
15. Lindström LS, et al. (2012) Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression. J Clin Oncol 30(21):2601-2608.
16. Hah N, et al. (2011) A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells. Cell 145(4):622-634.
17. Jakesz R, et al. (1984) Influence of cell proliferation and cell cycle phase on expression of estrogen receptor in MCF-7 breast cancer cells. Cancer Res 44(2):619-625.
18. Dong XF, Berthois Y, Colomb E, Martin PM (1991) Cell cycle phase dependence of estrogen and epidermal growth factor (EGF) receptor expression in MCF-7 cells: Implications in antiestrogen and EGF cell responsiveness. Endocrinology 129(5):2719-2728.
19. Rostagno P, Moll JL, Birtwisle-Peyrottes I, Ettore F, Caldani C (1996) Cell cycle expression of estrogen receptors determined by image analysis on human breast cancer cells in vitro and in vivo. Breast Cancer Res Treat 39(2):147-154.
20. Tanno B, et al. (2010) Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin. J Biol Chem 285(38):29434-29445.
21. Drabsch Y, et al. (2007) Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc Natl Acad Sci USA 104(34):13762-13767.
22. Guérin M, Sheng ZM, Andrieu N, Riou G (1990) Strong association between c-myb and oestrogen-receptor expression in human breast cancer. Oncogene 5(1):131-135.
23. Thorner AR, Parker JS, Hoadley KA, Perou CM (2010) Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer. PLoS ONE 5(10):e13073.
24. Jiang SY, Jordan VC (1992) Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J Natl Cancer Inst 84(8):580-591.
25. Lee Y, Renaud RA, Friedrich TC, Gorski J (1998) Estrogen causes cell death of estrogen receptor stably transfected cells via apoptosis. J Steroid Biochem Mol Biol 67(4): 327-332.
26. Klotz DM, et al. (2002) Requirement of estrogen receptor-α in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem 277(10):8531-8537.
27. Fu L, Lee CC (2003) The circadian clock: Pacemaker and tumour suppressor. Nat Rev Cancer 3(5):350-361.
28. Guillaumond F, Dardente H, Giguère V, Cermakian N (2005) Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. J Biol Rhythms 20(5):391-403.
29. Cai W, et al. (2008) Expression levels of estrogen receptor β are modulated by components of the molecular clock. Mol Cell Biol 28(2):784-793.
30. Cesi V, et al. (2011) TGFβ-induced c-Myb affects the expression of EMT-associated genes and promotes invasion of ER+ breast cancer cells. Cell Cycle 10(23):4149-4161.
31. Imayoshi I, et al. (2013) Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science 342(6163):1203-1208.
32. Herrington DM, et al. (2002) Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 346(13):967-974.
33. Jin Y, et al. (2008) Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy. J Clin Oncol 26(36):5849-5854.
34. Rivenbark AG, O'Connor SM, Coleman WB (2013) Molecular and cellular heterogeneity in breast cancer: Challenges for personalized medicine. Am J Pathol 183(4): 1113-1124.
35. Zeps N, Bentel JM, Papadimitriou JM, D'Antuono MF, Dawkins HJ (1998) Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth. Differentiation 62(5):221-226.
36. Sivaraman L, et al. (2001) Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation. J Endocrinol 171(1):75-83.
37. Capuco AV, Ellis S, Wood DL, Akers RM, Garrett W (2002) Postnatal mammary ductal growth: Three-dimensional imaging of cell proliferation, effects of estrogen treatment, and expression of steroid receptors in prepubertal calves. Tissue Cell 34(3):143-154.
38. Clarke RB, Howell A, Potten CS, Anderson E (1997) Dissociation between steroid receptor expression and cell proliferation in the human breast. Cancer Res 57(22): 4987-4991.
39. Ciana P, et al. (2003) Estrogen receptor α, a molecular switch converting transforming growth factor-α-mediated proliferation into differentiation in neuroblastoma cells. J Biol Chem 278(34):31737-31744.