-
1
-
-
77951464624
-
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
-
Benard G, et al. (2010) IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. EMBO J 29(8):1458-1471.
-
(2010)
EMBO J
, vol.29
, Issue.8
, pp. 1458-1471
-
-
Benard, G.1
-
2
-
-
0037013279
-
A novel zinc finger protein interacts with receptorinteracting protein (RIP) and inhibits tumor necrosis factor (TNF)-and IL1-induced NF-kappa B activation
-
Chen D, Li X, Zhai Z, Shu HB (2002) A novel zinc finger protein interacts with receptorinteracting protein (RIP) and inhibits tumor necrosis factor (TNF)-and IL1-induced NF-kappa B activation. J Biol Chem 277(18):15985-15991.
-
(2002)
J Biol Chem
, vol.277
, Issue.18
, pp. 15985-15991
-
-
Chen, D.1
Li, X.2
Zhai, Z.3
Shu, H.B.4
-
3
-
-
0037428078
-
Parc: A cytoplasmic anchor for p53
-
Nikolaev AY, Li M, Puskas N, Qin J, Gu W (2003) Parc: A cytoplasmic anchor for p53. Cell 112(1):29-40.
-
(2003)
Cell
, vol.112
, Issue.1
, pp. 29-40
-
-
Nikolaev, A.Y.1
Li, M.2
Puskas, N.3
Qin, J.4
Gu, W.5
-
4
-
-
79957949190
-
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
-
Wenzel DM, Lissounov A, Brzovic PS, Klevit RE (2011) UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature 474(7349):105-108.
-
(2011)
Nature
, vol.474
, Issue.7349
, pp. 105-108
-
-
Wenzel, D.M.1
Lissounov, A.2
Brzovic, P.S.3
Klevit, R.E.4
-
5
-
-
0042303805
-
P53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1
-
Ng CC, Arakawa H, Fukuda S, Kondoh H, Nakamura Y (2003) p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. Oncogene 22(28):4449-4458.
-
(2003)
Oncogene
, vol.22
, Issue.28
, pp. 4449-4458
-
-
Ng, C.C.1
Arakawa, H.2
Fukuda, S.3
Kondoh, H.4
Nakamura, Y.5
-
6
-
-
77955648341
-
Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2
-
Sayan BS, et al. (2010) Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proc Natl Acad Sci USA 107(29):12877-12882.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.29
, pp. 12877-12882
-
-
Sayan, B.S.1
-
7
-
-
0035174874
-
Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins
-
Martinez-Noel G, Müller U, Harbers K (2001) Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins. Eur J Biochem 268(22):5912-5919.
-
(2001)
Eur J Biochem
, vol.268
, Issue.22
, pp. 5912-5919
-
-
Martinez-Noel, G.1
Müller, U.2
Harbers, K.3
-
8
-
-
84863181098
-
Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A
-
Marzook H, et al. (2012) Metastasis-associated protein 1 drives tumor cell migration and invasion through transcriptional repression of RING finger protein 144A. J Biol Chem 287(8):5615-5626.
-
(2012)
J Biol Chem
, vol.287
, Issue.8
, pp. 5615-5626
-
-
Marzook, H.1
-
9
-
-
1542725073
-
Targeting the checkpoint kinases: Chemosensitization versus chemoprotection
-
Zhou BB, Bartek J (2004) Targeting the checkpoint kinases: Chemosensitization versus chemoprotection. Nat Rev Cancer 4(3):216-225.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.3
, pp. 216-225
-
-
Zhou, B.B.1
Bartek, J.2
-
10
-
-
62849083222
-
The emerging role of nuclear architecture in DNA repair and genome maintenance
-
Misteli T, Soutoglou E (2009) The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol 10(4):243-254.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, Issue.4
, pp. 243-254
-
-
Misteli, T.1
Soutoglou, E.2
-
11
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan ME, Jasin M (2010) Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 11(3):196-207.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, Issue.3
, pp. 196-207
-
-
Moynahan, M.E.1
Jasin, M.2
-
12
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber MR (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79:181-211.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
13
-
-
51849121635
-
DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
-
Mao Z, Bozzella M, Seluanov A, Gorbunova V (2008) DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7(18):2902-2906.
-
(2008)
Cell Cycle
, vol.7
, Issue.18
, pp. 2902-2906
-
-
Mao, Z.1
Bozzella, M.2
Seluanov, A.3
Gorbunova, V.4
-
14
-
-
8944241298
-
DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis
-
Song Q, et al. (1996) DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis. EMBO J 15(13):3238-3246.
-
(1996)
EMBO J
, vol.15
, Issue.13
, pp. 3238-3246
-
-
Song, Q.1
-
15
-
-
0029763211
-
DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease
-
Han Z, et al. (1996) DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J Biol Chem 271(40):25035-25040.
-
(1996)
J Biol Chem
, vol.271
, Issue.40
, pp. 25035-25040
-
-
Han, Z.1
-
16
-
-
79953299693
-
Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis
-
Lee KJ, et al. (2011) Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis. J Biol Chem 286(14):12796-12802.
-
(2011)
J Biol Chem
, vol.286
, Issue.14
, pp. 12796-12802
-
-
Lee, K.J.1
-
17
-
-
77951705618
-
Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage
-
Shang ZF, et al. (2010) Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage. Cancer Res 70(9):3657-3666.
-
(2010)
Cancer Res
, vol.70
, Issue.9
, pp. 3657-3666
-
-
Shang, Z.F.1
-
18
-
-
34247875990
-
Centrosomal localization of DNA damage checkpoint proteins
-
Zhang S, Hemmerich P, Grosse F (2007) Centrosomal localization of DNA damage checkpoint proteins. J Cell Biochem 101(2):451-465.
-
(2007)
J Cell Biochem
, vol.101
, Issue.2
, pp. 451-465
-
-
Zhang, S.1
Hemmerich, P.2
Grosse, F.3
-
19
-
-
15444368319
-
DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA
-
Dragoi AM, et al. (2005) DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. EMBO J 24(4):779-789.
-
(2005)
EMBO J
, vol.24
, Issue.4
, pp. 779-789
-
-
Dragoi, A.M.1
-
20
-
-
4644359805
-
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
-
Feng J, Park J, Cron P, Hess D, Hemmings BA (2004) Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem 279(39):41189-41196.
-
(2004)
J Biol Chem
, vol.279
, Issue.39
, pp. 41189-41196
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
21
-
-
0038496905
-
Novel localization of the DNA-PK complex in lipid rafts: A putative role in the signal transduction pathway of the ionizing radiation response
-
Lucero H, Gae D, Taccioli GE (2003) Novel localization of the DNA-PK complex in lipid rafts: A putative role in the signal transduction pathway of the ionizing radiation response. J Biol Chem 278(24):22136-22143.
-
(2003)
J Biol Chem
, vol.278
, Issue.24
, pp. 22136-22143
-
-
Lucero, H.1
Gae, D.2
Taccioli, G.E.3
-
22
-
-
77952572147
-
DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells
-
Rajagopalan S, Moyle MW, Joosten I, Long EO (2010) DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells. Sci Signal 3(110):ra14.
-
(2010)
Sci Signal
, vol.3
, Issue.110
-
-
Rajagopalan, S.1
Moyle, M.W.2
Joosten, I.3
Long, E.O.4
-
23
-
-
84863371816
-
Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci
-
Quanz M, et al. (2012) Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci. J Biol Chem 287(12):8803-8815.
-
(2012)
J Biol Chem
, vol.287
, Issue.12
, pp. 8803-8815
-
-
Quanz, M.1
-
24
-
-
40449101333
-
Endosomal translocation of CpG-oligodeoxynucleotides inhibits DNA-PKcs-dependent IL-10 production in macrophages
-
Yotsumoto S, Saegusa K, Aramaki Y (2008) Endosomal translocation of CpG-oligodeoxynucleotides inhibits DNA-PKcs-dependent IL-10 production in macrophages. J Immunol 180(2):809-816.
-
(2008)
J Immunol
, vol.180
, Issue.2
, pp. 809-816
-
-
Yotsumoto, S.1
Saegusa, K.2
Aramaki, Y.3
-
25
-
-
84875224757
-
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
-
Ferguson BJ, Mansur DS, Peters NE, Ren H, Smith GL (2012) DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. eLife 1:e00047.
-
(2012)
ELife
, vol.1
-
-
Ferguson, B.J.1
Mansur, D.S.2
Peters, N.E.3
Ren, H.4
Smith, G.L.5
-
26
-
-
51349087322
-
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation
-
Huston E, et al. (2008) EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proc Natl Acad Sci USA 105(35):12791-12796.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.35
, pp. 12791-12796
-
-
Huston, E.1
-
27
-
-
0031891006
-
Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells
-
Bandyopadhyay D, Mandal M, Adam L, Mendelsohn J, Kumar R (1998) Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J Biol Chem 273(3):1568-1573.
-
(1998)
J Biol Chem
, vol.273
, Issue.3
, pp. 1568-1573
-
-
Bandyopadhyay, D.1
Mandal, M.2
Adam, L.3
Mendelsohn, J.4
Kumar, R.5
-
28
-
-
79551510855
-
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
-
Liccardi G, Hartley JA, Hochhauser D (2011) EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res 71(3): 1103-1114.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 1103-1114
-
-
Liccardi, G.1
Hartley, J.A.2
Hochhauser, D.3
-
29
-
-
82455179484
-
Systematic and quantitative assessment of the ubiquitin-modified proteome
-
KimW, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell 44(2):325-340.
-
(2011)
Mol Cell
, vol.44
, Issue.2
, pp. 325-340
-
-
Kim, W.1
-
30
-
-
80054033461
-
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles
-
Wagner SA, et al. (2011) A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics 10(10): 013284.
-
(2011)
Mol Cell Proteomics
, vol.10
, Issue.10
, pp. 013284
-
-
Wagner, S.A.1
-
31
-
-
31444447978
-
The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis
-
Huang J, Xu LG, Liu T, Zhai Z, Shu HB (2006) The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. FEBS Lett 580(3):940-947.
-
(2006)
FEBS Lett
, vol.580
, Issue.3
, pp. 940-947
-
-
Huang, J.1
Xu, L.G.2
Liu, T.3
Zhai, Z.4
Shu, H.B.5
-
32
-
-
84869090231
-
Insights into p53 transcriptional function via genomewide chromatin occupancy and gene expression analysis
-
Nikulenkov F, et al. (2012) Insights into p53 transcriptional function via genomewide chromatin occupancy and gene expression analysis. Cell Death Differ 19(12): 1992-2002.
-
(2012)
Cell Death Differ
, vol.19
, Issue.12
, pp. 1992-2002
-
-
Nikulenkov, F.1
-
33
-
-
0141916811
-
Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses
-
Gentile M, Latonen L, Laiho M (2003) Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses. Nucleic Acids Res 31(16):4779-4790.
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.16
, pp. 4779-4790
-
-
Gentile, M.1
Latonen, L.2
Laiho, M.3
-
34
-
-
0029972136
-
Human Ku autoantigen binds cisplatin-damaged DNA but fails to stimulate human DNA-activated protein kinase
-
Turchi JJ, Henkels K (1996) Human Ku autoantigen binds cisplatin-damaged DNA but fails to stimulate human DNA-activated protein kinase. J Biol Chem 271(23): 13861-13867.
-
(1996)
J Biol Chem
, vol.271
, Issue.23
, pp. 13861-13867
-
-
Turchi, J.J.1
Henkels, K.2
-
35
-
-
0029798373
-
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0
-
Lees-Miller SP, et al. (1996) Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0. J Virol 70(11):7471-7477.
-
(1996)
J Virol
, vol.70
, Issue.11
, pp. 7471-7477
-
-
Lees-Miller, S.P.1
-
36
-
-
70349438994
-
Tumour suppression by p53: A role for the DNA damage response?
-
Meek DW (2009) Tumour suppression by p53: A role for the DNA damage response? Nat Rev Cancer 9(10):714-723.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.10
, pp. 714-723
-
-
Meek, D.W.1
-
37
-
-
84857443702
-
The p53 network: Cellular and systemic DNA damage responses in aging and cancer
-
Reinhardt HC, Schumacher B (2012) The p53 network: Cellular and systemic DNA damage responses in aging and cancer. Trends Genet 28(3):128-136.
-
(2012)
Trends Genet
, vol.28
, Issue.3
, pp. 128-136
-
-
Reinhardt, H.C.1
Schumacher, B.2
-
38
-
-
79960649509
-
Autoregulation of Parkin activity through its ubiquitin-like domain
-
Chaugule VK, et al. (2011) Autoregulation of Parkin activity through its ubiquitin-like domain. EMBO J 30(14):2853-2867.
-
(2011)
EMBO J
, vol.30
, Issue.14
, pp. 2853-2867
-
-
Chaugule, V.K.1
-
39
-
-
84867096523
-
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension
-
Smit JJ, et al. (2012) The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. EMBO J 31(19): 3833-3844.
-
(2012)
EMBO J
, vol.31
, Issue.19
, pp. 3833-3844
-
-
Smit, J.J.1
-
40
-
-
84865709638
-
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
-
Stieglitz B, Morris-Davies AC, Koliopoulos MG, Christodoulou E, Rittinger K (2012) LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Rep 13(9):840-846.
-
(2012)
EMBO Rep
, vol.13
, Issue.9
, pp. 840-846
-
-
Stieglitz, B.1
Morris-Davies, A.C.2
Koliopoulos, M.G.3
Christodoulou, E.4
Rittinger, K.5
-
41
-
-
0037007048
-
Large-scale analysis of the human and mouse transcriptomes
-
Su AI, et al. (2002) Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci USA 99(7):4465-4470.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.7
, pp. 4465-4470
-
-
Su, A.I.1
-
42
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh GL, et al. (2010) Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463(7279):360-363.
-
(2010)
Nature
, vol.463
, Issue.7279
, pp. 360-363
-
-
Dalgliesh, G.L.1
-
43
-
-
84863723010
-
The mutational landscape of lethal castration-resistant prostate cancer
-
Grasso CS, et al. (2012) The mutational landscape of lethal castration-resistant prostate cancer. Nature 487(7406):239-243.
-
(2012)
Nature
, vol.487
, Issue.7406
, pp. 239-243
-
-
Grasso, C.S.1
-
44
-
-
84866851740
-
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
-
Peifer M, et al. (2012) Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 44(10):1104-1110.
-
(2012)
Nat Genet
, vol.44
, Issue.10
, pp. 1104-1110
-
-
Peifer, M.1
-
45
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J, Coates J, Jackson SP (2005) Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434(7033):605-611.
-
(2005)
Nature
, vol.434
, Issue.7033
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
46
-
-
84879386947
-
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
-
Jiang N, et al. (2013) Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. Cell Death Dis 4:e647.
-
(2013)
Cell Death Dis
, vol.4
-
-
Jiang, N.1
-
47
-
-
33749236210
-
Diverse functions with a common regulator: Ubiquitin takes command of an AAA ATPase
-
Ye Y (2006) Diverse functions with a common regulator: Ubiquitin takes command of an AAA ATPase. J Struct Biol 156(1):29-40.
-
(2006)
J Struct Biol
, vol.156
, Issue.1
, pp. 29-40
-
-
Ye, Y.1
-
48
-
-
0036083829
-
Rab proteins mediate Golgi transport of caveolainternalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells
-
Choudhury A, et al. (2002) Rab proteins mediate Golgi transport of caveolainternalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells. J Clin Invest 109(12):1541-1550.
-
(2002)
J Clin Invest
, vol.109
, Issue.12
, pp. 1541-1550
-
-
Choudhury, A.1
|