Intrastriatal transplantation of retinal pigment epithelial cells for the treatment of Parkinson disease: In vivo longitudinal molecular imaging with 18F-P3BZA PET/CT

Radiology

Volumn 272, Issue 1, 2014, Pages 174-183

  Bu, Lihong ^a,b   Li, Renfei ^a,b   Liu, Hongguang ^a   Feng, Wei ^c   Xiong, Xiaoxing ^c   Zhao, Heng ^c   Vollrath, Douglas ^c   Shen, Baozhong ^b   Cheng, Zhen ^a  

^a STANFORD UNIVERSITY   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EOSIN; GELATIN; HEMATOXYLIN; N [2 (DIETHYLAMINO)ETHYL] 5 FLUOROPICOLINAMIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CANCER CELL LINE; CELL TRANSPLANTATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FONTANA MASSON STAINING; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LONG TERM CARE; LONGITUDINAL STUDY; NONHUMAN; PARKINSON DISEASE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; REGRESSION ANALYSIS; RETINAL PIGMENT EPITHELIUM TRANSPLANTATION; STUDENT T TEST;

ANIMALS; AUTORADIOGRAPHY; CORPUS STRIATUM; FEMALE; FLUORINE RADIOISOTOPES; IMMUNOHISTOCHEMISTRY; MOLECULAR IMAGING; MULTIMODAL IMAGING; PARKINSON DISEASE; PICOLINIC ACIDS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RETINAL PIGMENT EPITHELIUM; STAINING AND LABELING; SWINE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84903721781     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.14132042     Document Type: Article

References (36)

1. de Lau LM, Breteler MM. Epidemiology of Parkinson's disease. Lancet Neurol 2006;5(6):525-535. (Pubitemid 44262284)
2. Olanow CW. Levodopa/dopamine replacement strategies in Parkinson's disease - future directions. Mov Disord 2008;23(Suppl 3):S613-S622.
3. Poewe W, Mahlknecht P, Jankovic J. Emerging therapies for Parkinson's disease. Curr Opin Neurol 2012;25(4):448-459.
4. Olanow CW, Obeso JA, Stocchi F. Continuous dopamine-receptor treatment of Parkinson's disease: scientific rationale and clinical implications. Lancet Neurol 2006;5(8):677-687. (Pubitemid 44081890)
5. Hayes MW, Fung VS, Kimber TE, O'Sullivan JD. Current concepts in the management of Parkinson disease. Med J Aust 2010;192(3):144-149.
6. Roffler-Tarlov S, Liu JH, Naumova EN, Bernal-Ayala MM, Mason CA. L-Dopa and the albino riddle: content of L-Dopa in the developing retina of pigmented and albino mice. PLoS ONE 2013;8(3):e57184.
7. Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D. Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J Neurosci 1995;15(7 Pt 1):4992-5003.
8. Schraermeyer U, Kopitz J, Peters S, et al. Tyrosinase biosynthesis in adult mammalian retinal pigment epithelial cells. Exp Eye Res 2006;83(2):315-321. (Pubitemid 43850947)
9. Dorey CK, Torres X, Swart T. Evidence of melanogenesis in porcine retinal pigment epithelial cells in vitro. Exp Eye Res 1990;50(1):1-10. (Pubitemid 20058616)
10. Kubrusly RC, Guimarães MZ, Vieira AP, et al. L-DOPA supply to the neuro retina activates dopaminergic communication at the early stages of embryonic development. J Neurochem 2003;86(1):45-54.
11. Flores J, Cepeda IL, Cornfeldt ML, O'Kusky JR, Doudet DJ. Characterization and survival of long-term implants of human retinal pigment epithelial cells attached to gelatin microcarriers in a model of Parkinson disease. J Neuropathol Exp Neurol 2007;66(7):585-596. (Pubitemid 47051704)
12. Subramanian T, Marchionini D, Potter EM, Cornfeldt ML. Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response. Cell Transplant 2002;11(3):207-214. (Pubitemid 34665821)
13. Watts RL, Raiser CD, Stover NP, et al. Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson's disease. J Neural Transm Suppl 2003(65):215-227. (Pubitemid 38339958)
14. Stover NP, Bakay RA, Subramanian T, et al. Intrastriatal implantation of human retinal pigment epithelial cells attached to microcarriers in advanced Parkinson disease. Arch Neurol 2005;62(12):1833-1837. (Pubitemid 41785076)
15. Stover NP, Watts RL. Spheramine for treatment of Parkinson's disease. Neurotherapeutics 2008;5(2):252-259. (Pubitemid 351447332)
16. Gross RE, Watts RL, Hauser RA, et al. Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol 2011;10(6):509-519.
17. Cenci MA, Widner H. Parkinson disease: poor results for retinal cell transplants in Parkinson disease. Nat Rev Neurol 2011;7(8):424-425.
18. Albanese A. Cell therapy for Parkinson's disease: have the glory days gone? Lancet Neurol 2011;10(6):492-493.
19. McKay BS, Goodman B, Falk T, Sherman SJ. Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system. Exp Neurol 2006;201(1):234-243.
20. Zareba M, Raciti MW, Henry MM, Sarna T, Burke JM. Oxidative stress in ARPE-19 cultures: do melanosomes confer cytoprotection? Free Radic Biol Med 2006;40(1): 87-100. (Pubitemid 41759406)
21. Liu H, Liu S, Miao Z, et al. Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma. J Med Chem 2013;56(3):895-901.
22. Qin C, Cheng K, Chen K, et al. Tyrosinase as a multifunctional reporter gene for photoacoustic/MRI/PET triple modality molecular imaging. Sci Rep 2013;3:1490.
23. Zhang HL, Wu JJ, Ren HM, Wang J, Su YR, Jiang YP. Therapeutic effect of microencapsulated porcine retinal pigmented epithelial cells transplantation on rat model of Parkinson's disease. Neurosci Bull 2007;23(3):137-144. (Pubitemid 47104867)
24. Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 1996;62(2):155-169. (Pubitemid 26140102)
25. Feng W, Yasumura D, Matthes MT, LaVail MM, Vollrath D. Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells. J Biol Chem 2002;277(19):17016-17022. (Pubitemid 34967730)
26. Kim HJ, Kim DY, Park JH, et al. Synthesis and characterization of a (68)Ga-labeled N-(2-diethylaminoethyl)benzamide derivative as potential PET probe for malignant melanoma. Bioorg Med Chem 2012;20(16):4915-4920.
27. Ren G, Miao Z, Liu H, et al. Melanin-targeted preclinical PET imaging of melanoma metastasis. J Nucl Med 2009;50(10):1692-1699.
28. Ishikawa M, Kawase I, Ishii F. Glycine inhibits melanogenesis in vitro and causes hypopigmentation in vivo. Biol Pharm Bull 2007;30(11):2031-2036. (Pubitemid 350097035)
29. Cepeda IL, Flores J, Cornfeldt ML, O'Kusky JR, Doudet DJ. Human retinal pigment epithelial cell implants ameliorate motor deficits in two rat models of Parkinson disease. J Neuropathol Exp Neurol 2007;66(7):576-584. (Pubitemid 47051703)
30. Fedorow H, Tribl F, Halliday G, Gerlach M, Riederer P, Double KL. Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson's disease. Prog Neurobiol 2005;75(2):109-124. (Pubitemid 40387414)
31. Wang R, Zhang J, Guo Z, et al. In-vivo PET imaging of implanted human retinal pigment epithelium cells in a Parkinson's disease rat model. Nucl Med Commun 2008;29(5):455-461. (Pubitemid 351507539)
32. Doudet DJ, Cornfeldt ML, Honey CR, Schweikert AW, Allen RC. PET imaging of implanted human retinal pigment epithelial cells in the MPTP-induced primate model of Parkinson's disease. Exp Neurol 2004;189(2):361-368. (Pubitemid 39221828)
33. Yin F, Tian ZM, Liu S, et al. Transplantation of human retinal pigment epithelium cells in the treatment for Parkinson disease. CNS Neurosci Ther 2012;18(12):1012-1020.
34. Farag ES, Vinters HV, Bronstein J. Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease. Neurology 2009;73(14):1095-1102.
35. Schraermeyer U. Does melanin turnover occur in the eyes of adult vertebrates? Pigment Cell Res 1993;6(4 Pt 1):193-204.
36. Sarna T, Burke JM, Korytowski W, et al. Loss of melanin from human RPE with aging: possible role of melanin photooxidation. Exp Eye Res 2003;76(1):89-98. (Pubitemid 36268718)