Combined SPECT/CT improves detection of initial bone invasion and determination of resection margins in squamous cell carcinoma of the head and neck compared to conventional imaging modalities

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 41, Issue 7, 2014, Pages 1363-1374

  Kolk, A ^a   Schuster, T ^b   Chlebowski, A ^a   Lange, P ^a,c   Scheidhauer, K ^a   Kesting, M ^a   Bissinger, O ^a   Schwaiger, M ^a   Dinges, J ^a   Weitz, J ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c BALLARAT HEALTH SERVICES   (Australia)

Author keywords

Combined SPECT CT; High resolution MRI; Mandibular bone invasion; Multislice CT; Squamous cell carcinoma

Indexed keywords

GADOLINIUM PENTETATE MEGLUMINE; IOMEPROL; OXIDRONATE TECHNETIUM TC 99M;

ADULT; AGED; ARTICLE; BONE DESTRUCTION; BONE METASTASIS; BONE RESECTION; CANCER DIAGNOSIS; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG UPTAKE; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LONGITUDINAL STUDY; MALE; MANDIBLE RESECTION; MULTIDETECTOR COMPUTED TOMOGRAPHY; PANORAMIC RADIOGRAPHY; PREDICTIVE VALUE; RADIODIAGNOSIS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; BONE; CARCINOMA, SQUAMOUS CELL; COMPARATIVE STUDY; HEAD AND NECK NEOPLASMS; MIDDLE AGED; MULTIMODAL IMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; SURGERY; TUMOR INVASION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BONE AND BONES; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIMODAL IMAGING; NEOPLASM INVASIVENESS; RADIOGRAPHY, PANORAMIC; RETROSPECTIVE STUDIES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84903721565     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-014-2726-6     Document Type: Article

References (54)

1. Kolk A, Jubitz N, Mengele K, Mantwill K, Bissinger O, Schmitt M, et al. Expression of Y-box-binding protein YB-1 allows stratification into long- and short-term survivors of head and neck cancer patients. Br J Cancer. 2011;105:1864-73. doi:10.1038/bjc.2011.491.
2. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011;333:1157-60. doi:10.1126/science.1208130.
3. Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. Cancer. 2005;103:1843-9. (Pubitemid 40563256)
4. Jones AS, England J, Hamilton J, Helliwell TR, Field J, Gerlinger I, et al. Mandibular invasion in patients with oral and oropharyngeal squamous carcinoma. Clin Otolaryngol Allied Sci. 1997;22:239-45. (Pubitemid 28344975)
5. Ash CS, Nason RW, Abdoh AA, Cohen MA. Prognostic implications of mandibular invasion in oral cancer. Head Neck. 2000;22:794-8. doi:10.1002/1097-0347(200012)22:8〈794::AID-HED8〉3.0.CO;2-W.
6. O'Brien CJ, Carter RL, Soo KC, Barr LC, Hamlyn PJ, Shaw HJ. Invasion of the mandible by squamous carcinomas of the oral cavity and oropharynx. Head Neck Surg. 1986;8:247-56.
7. Werning JW, Byers RM, Novas MA, Roberts D. Preoperative assessment for and outcomes of mandibular conservation surgery. Head Neck. 2001;23:1024-30. doi:10.1002/hed.10031. (Pubitemid 33107931)
8. Quan J, Johnson NW, Zhou G, Parsons PG, Boyle GM, Gao J. Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms. Cancer Metastasis Rev. 2012;31:209-19. doi:10.1007/s10555-011-9335-7.
9. Ebrahimi A, Murali R, Gao K, Elliott MS, Clark JR. The prognostic and staging implications of bone invasion in oral squamous cell carcinoma. Cancer. 2011;117:4460-7. doi:10.1002/cncr.26032.
10. Wiener E, Pautke C, Link TM, Neff A, Kolk A. Comparison of 16-slice MSCT and MRI in the assessment of squamous cell carcinoma of the oral cavity. Eur J Radiol. 2006;58:113-8. doi:10.1016/j.ejrad.2005.11.006.
11. Mukherji SK, Isaacs DL, Creager A, Shockley W, Weissler M, Armao D. CT detection of mandibular invasion by squamous cell carcinoma of the oral cavity. AJR Am J Roentgenol. 2001;177:237-43. (Pubitemid 32578089)
12. Toegel S, Hoffmann O, Wadsak W, Ettlinger D, Mien LK, Wiesner K, et al. Uptake of bone-seekers is solely associated with mineralisation! A study with 99mTc-MDP, 153Sm-EDTMP and 18F-fluoride on osteoblasts. Eur J Nucl Med Mol Imaging. 2006;33:491-4. doi:10.1007/s00259-005-0026-x.
13. Chen YL, Kuo SW, Fang KH, Hao SP. Prognostic impact of marginal mandibulectomy in the presence of superficial bone invasion and the nononcologic outcome. Head Neck. 2011;33:708-13. doi:10.1002/hed.21530.
14. Hoffmannova J, Foltan R, Vlk M, Sipos M, Horka E, Pavlikova G, et al. Hemimandibulectomy and therapeutic neck dissection with radiotherapy in the treatment of oral squamous cell carcinoma involving mandible: a critical review of treatment protocol in the years 1994-2004. Int J OralMaxillofac Surg. 2010;39:561-7. doi:10.1016/j.ijom.2010.03.010.
15. Lubek J, El-Hakim M, Salama AR, Liu X, Ord RA. Gingival carcinoma: retrospective analysis of 72 patients and indications for elective neck dissection. Br J Oral Maxillofac Surg. 2011;49:182-5. doi:10.1016/j.bjoms.2010. 04.005.
16. Brown JS, Kalavrezos N, D'Souza J, Lowe D, Magennis P, Woolgar JA. Factors that influence the method of mandibular resection in the management of oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 2002;40:275-84.
17. Brown JS, Griffith JF, Phelps PD, Browne RM. A comparison of different imaging modalities and direct inspection after periosteal stripping in predicting the invasion of the mandible by oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 1994;32:347-59. (Pubitemid 24368275)
18. Baker HL, Woodbury DH, Krause CJ, Saxon KG, Stewart RC. Evaluation of bone scan by scintigraphy to detect subclinical invasion of the mandible by squamous cell carcinoma of the oral cavity. Otolaryngol Head Neck Surg. 1982;90:327-36. (Pubitemid 12048380)
19. Barttelbort SW, Bahn SL, Ariyan SA. Rim mandibulectomy for cancer of the oral cavity. Am J Surg. 1987;154:423-8. (Pubitemid 18024390)
20. Leipzig B. Assessment of mandibular invasion by carcinoma. Cancer. 1985;56:1201-5. (Pubitemid 15003510)
21. Luyk NH, Laird EE, Ward-Booth P, Rankin D, Williams ED. The use of radionuclide bone scintigraphy to determine local spread of oral squamous cell carcinoma to mandible. J Maxillofac Surg. 1986;14:93-8. (Pubitemid 16115965)
22. Muller H, Slootweg PJ. Mandibular invasion by oral squamous cell carcinoma. Clinical aspects. J Craniomaxillofac Surg. 1990;18:80-4. (Pubitemid 20128432)
23. Ord RA, Sarmadi M, Papadimitrou J. A comparison of segmental and marginal bony resection for oral squamous cell carcinoma involving the mandible. J Oral Maxillofac Surg. 1997;55:470-7; discussion 477-8.
24. Soderholm AL, Lindqvist C, Hietanen J, Lukinmaa PL. Bone scanning for evaluating mandibular bone extension of oral squamous cell carcinoma. J Oral Maxillofac Surg. 1990;48:252-7. (Pubitemid 20092578)
25. Totsuka Y, Usui Y, Tei K, Fukuda H, Shindo M, Iizuka T, et al. Mandibular involvement by squamous cell carcinoma of the lower alveolus: analysis and comparative study of histologic and radiologic features. Head Neck. 1991;13:40-50.
26. Imaizumi A, Yoshino N, Yamada I, Nagunno K, Amagasa T, Omura K, et al. A potential pitfall of MR imaging for assessing mandibular invasion of squamous cell carcinoma in the oral cavity. AJNR Am J Neuroradiol. 2006;27:114-22. (Pubitemid 46939896)
27. Momin MA, Okochi K, Watanabe H, Imaizumi A, Omura K, Amagasa T, et al. Diagnostic accuracy of cone-beam CT in the assessment of mandibular invasion of lower gingival carcinoma: comparison with conventional panoramic radiography. Eur J Radiol. 2009;72:75-81. doi:10.1016/j.ejrad.2008.06.018.
28. Van Cann EM, Rijpkema M, Heerschap A, van der Bilt A, Koole R, Stoelinga PJW. Quantitative dynamic contrast-enhanced MRI for the assessment of mandibular invasion by squamous cell carcinoma. Oral Oncol. 2008;44:1147-54. doi:10.1016/j.oraloncology.2008.02.009.
29. Gilbert S, Tzadik A, Leonard G. Mandibular involvement by oral squamous cell carcinoma. Laryngoscope. 1986;96:96-101. (Pubitemid 16183422)
30. Ahuja RB, Soutar DS, Moule B, Bessent RG, Gray H. Comparative study of technetium-99m bone scans and orthopantomography in determining mandible invasion in intraoral squamous cell carcinoma. Head Neck. 1990;12:237-43. (Pubitemid 20155004)
31. Bergstedt HF, Lind MG, Silfversward C. Facial bone scintigraphy. VII. Diagnosis of malignant lesions in the mandible. Acta Radiol Diagn (Stockh). 1981;22:485-93. (Pubitemid 12244556)
32. Fischer-Brandies E, Seifert C. Bone scintigraphy: an aid in deciding on the extent of bone resection in malignant oral tumors. J Oral Maxillofac Surg. 1995;53:768-70.
33. Pogrel MA. The marginal mandibulectomy for the treatment of mandibular tumours. Br J Oral Maxillofac Surg. 1989;27:132-8. (Pubitemid 19118455)
34. Zupi A, Califano L, Maremonti P, Longo F, Ciccarelli R, Soricelli A. Accuracy in the diagnosis of mandibular involvement by oral cancer. J Craniomaxillofac Surg. 1996;24:281-4. (Pubitemid 26390513)
35. Seabold JE, Simonson TM, Weber PC, Thompson BH, Harris KG, Rezai K, et al. Cranial osteomyelitis: diagnosis and follow-up with In-111 white blood cell and Tc-99m methylene diphosphonate bone SPECT, CT, and MR imaging. Radiology. 1995;196:779-88.
36. Rajesh A, Khan A, Kendall C, Hayter J, Cherryman G. Can magnetic resonance imaging replace single photon computed tomography and computed tomography in detecting bony invasion in patients with oral squamous cell carcinoma? Br J Oral Maxillofac Surg. 2008;46:11-4. doi:10.1016/j.bjoms.2007.08. 024. (Pubitemid 350266151)
37. Schimming R, Juengling FD, Lauer G, Altehofer C, Schmelzeisen R. Computer-aided 3-D 99mTc-DPD-SPECT reconstruction to assess mandibular invasion by intraoral squamous cell carcinoma: diagnostic improvement or not? J Craniomaxillofac Surg. 2000;28:325-30. doi:10.1054/jcms.2000.0171. (Pubitemid 32243890)
38. Schillaci O. Hybrid SPECT/CT: a new era for SPECTimaging? Eur J Nucl Med Mol Imaging. 2005;32:521-4. doi:10.1007/s00259-005-1760-9. (Pubitemid 41214193)
39. Gnanasegaran G, Cook G, Adamson K, Fogelman I. Patterns, variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Semin Nucl Med. 2009;39:380-95. doi:10.1053/j.semnuclmed.2009.07.003.
40. Abikhzer G, Keidar Z. SPECT/CT and tumour imaging. Eur J Nucl Med Mol Imaging. 2013. doi:10.1007/s00259-013-2534-4.
41. Kolk A, Pautke C, Wiener E, Schott V, Wolff KD, Horch HH, et al. Isotropic proton-density-weighted high-resolution MRI for volume measurement of reconstructed orbital fractures - a comparison with multislice CT. Magn Reson Imaging. 2008;26:1167-74. doi:10.1016/j.mri.2008.01.017.
42. Kolk A, Stimmer H, Klopfer M, Wolff KD, Hohlweg-Majert B, Ploder O, et al. High resolution magnetic resonance imaging with an orbital coil as an alternative to computed tomography scan as the primary imaging modality of pediatric orbital fractures. J Oral Maxillofac Surg. 2009;67:348-56. doi:10.1016/j.joms.2008.04.003.
43. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159-74. (Pubitemid 8054849)
44. Handschel J, Naujoks C, Depprich RA, Kubler NR, Kropil P, Kuhlemann J, et al. CT-scan is a valuable tool to detect mandibular involvement in oral cancer patients. Oral Oncol. 2011;48:361-6. doi:10.1016/j.oraloncology.2011.11.009.
45. Lane AP, Buckmire RA, Mukherji SK, Pillsbury 3rd HC, Meredith SD. Use of computed tomography in the assessment of mandibular invasion in carcinoma of the retromolar trigone. Otolaryngol Head Neck Surg. 2000;122:673-7. (Pubitemid 30333843)
46. Nomura T, Shibahara T, Cui NH, Noma H. Patterns of mandibular invasion by gingival squamous cell carcinoma. J Oral Maxillofac Surg. 2005;63:1489-93. doi:10.1016/j.joms.2005.05.321. (Pubitemid 41355012)
47. Jimi E, Furuta H, Matsuo K, Tominaga K, Takahashi T, Nakanishi O. The cellular and molecular mechanisms of bone invasion by oral squamous cell carcinoma. Oral Dis. 2011;17:462-8. doi:10.1111/j.1601-0825.2010.01781.x.
48. Van Cann EM, Koole R, Oyen WJ, de Rooy JW, de Wilde PC, Slootweg PJ, et al. Assessment of mandibular invasion of squamous cell carcinoma by various modes of imaging: constructing a diagnostic algorithm. Int J Oral Maxillofac Surg. 2008;37:535-41. doi:10.1016/j.ijom.2008.02.009. (Pubitemid 351726424)
49. Van Cann EM, Dom M, Koole R, Merkx MA, Stoelinga PJ. Health related quality of life after mandibular resection for oral and oropharyngeal squamous cell carcinoma. Oral Oncol. 2005;41:687-93. doi:10.1016/j.oraloncology.2005.03. 001. (Pubitemid 40981108)
50. van Gemert JT, van Es RJ, Rosenberg AJ, van der Bilt A, Koole R, Van Cann EM. Free vascularized flaps for reconstruction of the mandible: complications, success, and dental rehabilitation. J Oral Maxillofac Surg. 2012;70:1692-8. doi:10.1016/j.joms.2011.08.024.
51. Dammann F, Horger M, Mueller-Berg M, Schlemmer H, Claussen CD, Hoffman J, et al. Rational diagnosis of squamous cell carcinoma of the head and neck region: comparative evaluation of CT, MRI, and 18FDG PET. AJR Am J Roentgenol. 2005;184:1326-31. (Pubitemid 43821922)
52. Dubner S, Heller KS. Local control of squamous cell carcinoma following marginal and segmental mandibulectomy. Head Neck. 1993;15:29-32. (Pubitemid 23003470)
53. Goerres GW, Schmid DT, Schuknecht B, Eyrich GK. Bone invasion in patients with oral cavity cancer: comparison of conventional CT with PET/CT and SPECT/CT. Radiology. 2005;237:281-7. doi:10.1148/radiol.2371041228. (Pubitemid 41346175)
54. Keidar Z, Israel O, Krausz Y. SPECT/CT in tumor imaging: technical aspects and clinical applications. Semin Nucl Med. 2003;33:205-18. doi:10.1053/snuc.2003.127310. (Pubitemid 36859499)