Hypomethylation and activation of syncytin-1 gene in endometriotic tissue

Current Pharmaceutical Design

Volumn 20, Issue 11, 2014, Pages 1786-1795

  Zhou, Hongyuan ^a,b   Li, Jinping ^b,c,d   Podratz, Karl C ^c   Tipton, Tracy ^b   Marzolf, Susan ^e   Chen, Hai Bin ^f   Jiang, Shi Wen ^b,c,d  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

^d MEMORIAL HEALTH UNIVERSITY MEDICAL CENTER   (United States)

^e MAYO CLINIC   (United States)

^f SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

DNA methylation; DNMT3B isoforms; HERV W; Non fusogenic; Syncytin 1

Indexed keywords

BISULFITE; DNA METHYLTRANSFERASE 3B; METHYLTRANSFERASE; SYNCYTIN 1; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; MESSENGER RNA; PLACENTA PROTEIN; SYNCYTIN; VIRUS ENVELOPE PROTEIN;

ADULT; ARTICLE; CANCER CELL; CLINICAL ARTICLE; DNA METHYLATION; ENDOGENOUS RETROVIRUS; ENDOMETRIOSIS; ENDOMETRIUM; ENVELOPE GENE; ENZYME ACTIVITY; FEMALE; GENE ACTIVATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SYNCYTIOTROPHOBLAST; TROPHOBLAST; UPREGULATION; DOWN REGULATION; ENDOTHELIUM CELL; GENE SILENCING; GENETIC EPIGENESIS; GENETICS; METABOLISM; PATHOLOGY; YOUNG ADULT;

ADULT; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; ENDOMETRIOSIS; ENDOMETRIUM; ENDOTHELIAL CELLS; EPIGENESIS, GENETIC; FEMALE; GENE PRODUCTS, ENV; GENE SILENCING; HUMANS; PREGNANCY PROTEINS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; UP-REGULATION; YOUNG ADULT;

EID: 84903689507     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990540     Document Type: Article

References (48)

1. Giudice LC, Kao LC. Endometriosis. Lancet 2004; 364: 1789-99.
2. Matalliotakis IM, Cakmak H, Fragouli YG, et al. Epidemiological characteristics in women with and without endometriosis in the Yale series. Arch Gynecol Obstet 2008; 277: 389-93.
3. Fritz MA SL. Clinical Gynecologic Endocrinology and Infertility. Philadelphia: Lippincott Williams and Wilkins 2011; 1221-48.
4. Bischoff F, Simpson JL. Genetics of endometriosis: heritability and candidate genes Best Pract Res Clin Obstet Gynaecol 2004; 18: 219-32.
5. Swiersz LM. Role of endometriosis in cancer and tumor development. Ann N Y Acad Sci 2002; 955: 281-92
6. Heaps JM, Nieberg RK., Berek JS. Malignant neoplasms arising in endometriosis Obstet Gynecol 1990; 75: 1023-8.
7. Cho HY, Kim MK, Cho SJ, et al. Endometrial stromal sarcoma of the sigmoid colon arising in endometriosis: a case report with a review of literatures. J Korean Med Sci 2002; 17: 412-4.
8. Mi S, Lee X, Li X, et al. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 2000; 403: 785-9.
9. Gimenez J, Montgiraud C, Oriol G, et al. Comparative methylation of ERVWE1/syncytin-1 and other human endogenous retrovirus LTRs in placenta tissues. DNA Res 2009; 16: 195-211.
10. Menendez L, Benigno BB., McDonald JF. L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas. Mol Cancer 2004; 3: 12.
11. Strissel PL, Ruebner M, Thiel F, et al. Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets. Oncotarget 2012; 3: 1204-19.
12. Strick R, Ackermann S, Langbein M, et al. Proliferation and cellcell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta. J Mol Med (Berl) 2007; 85: 23-38.
13. Oppelt P, Strick R, Strissel PL, et al. Expression of the human endogenous retroviruse-W envelope gene syncytin in endometriosis lesions. Gynecol Endocrinol 2009; 25: 741-7.
14. Wu Y, Halverson G, Basir Z, et al. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis Am J Obstet Gynecol 2005; 193: 371-80.
15. Gurates B, Bulun SE. Endometriosis: the ultimate hormonal disease. Semin Reprod Med 2003; 21: 125-34.
16. Wu Y, Strawn E, Basir Z, et al. Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. Epigenetics 2006; 1: 106-11.
17. Jin F, Dowdy SC, Xiong Y, et al. Up-regulation of DNA methyltransferase 3B expression in endometrial cancers Gynecol Oncol 2005; 96: 531-8.
18. Ehrlich M. Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr Top Microbiol Immunol 2006; 310: 251-74.
19. Jacquemin P, Alsat E, Oury C, et al. The enhancers of the human placental lactogen B, A, and L genes: progressive activation during in vitro trophoblast differentiation and importance of the DF-3 element in determining their respective activities. DNA Cell Biol 1996; 15: 845-54.
20. Jiang SW, Eberhardt NL. The human chorionic somatomammotropin gene enhancer is composed of multiple DNA elements that are homologous to several SV40 enhansons. J Biol Chem 1994; 269: 10384-92.
21. Weisenberger DJ, Velicescu M, Cheng JC, et al. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res 2004; 2: 62-72.
22. Cheynet V, Ruggieri A, Oriol G, et al. Synthesis, assembly, and processing of the Env ERVWE1/syncytin human endogenous retroviral envelope. J Virol 2005; 79: 5585-93.
23. Kudo Y, Boyd CA, Sargent IL, et al. Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia. Biochim Biophys Acta 2003; 1638: 63-71.
24. Blond JL, Lavillette D, Cheynet V, et al. An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J Virol 2000; 74: 3321-9.
25. Marin M, Lavillette D, Kelly SM, et al. N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. J Virol 2003; 77: 2936-45.
26. Antony JM, Ellestad KK, Hammond R, et al. The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes. J Immunol 2007; 179: 1210-24.
27. Tolosa JM, Schjenken JE, Clifton VL, et al. The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. Placenta 2012; 33: 933-41.
28. Huang Q, Li J, Wang F, et al. Syncytin-1 modulates placental trophoblast cell proliferation by promoting G1/S transition. Cell Signal 2013; 25: 1027-35.
29. Bollati V, Schwartz J, Wright R, et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2009; 130: 234-9.
30. Ohka F, Natsume A, Motomura K, et al. The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma. PLoS One 2011; 6: e23332.
31. Saito K, Kawakami K, Matsumoto I, et al. Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer. Clin Cancer Res 2010; 16: 2418-26.
32. Esteller M, Herman JG. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 2002; 196: 1-7.
33. Matouskova M, Blazkova J, Pajer P, et al. CpG methylation suppresses transcriptional activity of human syncytin-1 in nonplacental tissues. Exp Cell Res 2006; 312: 1011-20.
34. Yu C, Shen K, Lin M, et al. GCMa regulates the syncytin-mediated trophoblastic fusion. J Biol Chem 2002; 277: 50062-8.
35. Knerr I, Schubert SW, Wich C, et al. Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions FEBS Lett 2005; 579: 3991-8.
36. Gao Y, He Z, Wang Z, et al. Increased expression and altered methylation of HERVWE1 in the human placentas of smaller fetuses from monozygotic, dichorionic, discordant twins. PLoS ONE 2012; 7: e33503.
37. Trejbalova K, Blazkova J, Matouskova M, et al. Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin. Nucleic Acids Res 2011; 39: 8728-39.
38. Wu Y, Strawn E, Basir Z, et al. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Fertil Steril 2007; 87: 24-32.
39. Ehrlich M The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease. Clin Immunol 2003; 109, 17-28.
40. Xiong Y, Dowdy S C, Xue A, et al. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Gynecol Oncol 2005; 96: 601-9.
41. Aoki A, Suetake I, Miyagawa J, et al. Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases. Nucleic Acids Res 2001; 29: 3506-12.
42. Chen T, Ueda Y, Dodge JE, et al. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol 2003; 23: 5594-605.
43. Soejima K, Fang W., Rollins BJ. DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras. Oncogene 2003; 22: 4723-33.
44. Shen H, Wang L, Spitz MR, et al. A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res 2002; 62: 4992-5.
45. Saito Y, Kanai Y, Sakamoto M, et al. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci USA 2002; 99: 10060-5.
46. Markestad T, Bergsjo P, Aakvaag A, et al. Prediction of fetal growth based on maternal serum concentrations of human chorionic gonadotropin, human placental lactogen and estriol. Acta Obstet Gynecol Scand Suppl 1997; 165: 50-5.
47. Larsson LI, Holck S., Christensen IJ. Prognostic role of syncytin expression in breast cancer. Hum Pathol 2007; 38: 726-31.
48. Crowther ME, Grudzinskas JG, Poulton TA, et al. Trophoblastic proteins in ovarian carcinoma. Obstet Gynecol 1979; 53: 59-61.