Zinc ions modulate protein tyrosine phosphatase 1B activity

Metallomics

Volumn 6, Issue 7, 2014, Pages 1229-1239

  Bellomo, Elisa ^a   Massarotti, Alberto ^b   Hogstrand, Christer ^a   Maret, Wolfgang ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; IONS; PHOSPHATASES; PROTEINS; ZINC COMPOUNDS;

CELLULAR ENVIRONMENT; CELLULAR REGULATION; ENDOPLASMIC RETICULUM; PROTEIN-TYROSINE PHOSPHATASE; PROTEIN-TYROSINE PHOSPHATASE 1B; REDOX SIGNALLING; SIGNALLING PATHWAYS; ZINC-BINDING SITES;

ZINC;

INSULIN; LEPTIN; PROTEIN TYROSINE PHOSPHATASE 1B; ZINC ION; EDETIC ACID; ENZYME INHIBITOR; INSULIN RECEPTOR; LEPTIN RECEPTOR; PTPN1 PROTEIN, HUMAN; ZINC;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR DOCKING;

BINDING SITES; EDETIC ACID; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RECEPTOR, INSULIN; RECEPTORS, LEPTIN; ZINC;

EID: 84903648604     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c4mt00086b     Document Type: Article

References (59)

1. E. H. Fischer Cell signaling by protein tyrosine phosphorylation Adv. Enzyme Regul. 1999 39 359 369
2. N. K. Tonks Protein tyrosine phosphatases: from genes, to function, to disease Nat. Rev. Mol. Cell Biol. 2006 7 833 846 10.1038/nrm2039
3. M. Feldhammer N. Uetani D. Miranda-Saavedra M. L. Tremblay PTP1B: a simple enzyme for a complex world Crit. Rev. Biochem. Mol. Biol. 2013 48 430 445 10.3109/10409238.2013.819830
4. J. V. Frangioni P. H. Beahm V. Shifrin C. A. Jost B. G. Neel The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence Cell 1992 68 545 560
5. K. A. Kenner E. Anyanwu J. M. Olefsky J. Kusari Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling J. Biol. Chem. 1996 271 19810 19816
6. A. Cheng N. Uetani P. D. Simoncic V. P. Chaubey A. Lee-Loy C. J. McGlade B. P. Kennedy M. L. Tremblay Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B Dev. Cell 2002 2 497 503
7. M. Elchebly P. Payette E. Michaliszyn W. Cromlish S. Collins A. L. Loy D. Normandin A. Cheng J. Himms-Hagen C. C. Chan C. Ramachandran M. J. Gresser M. L. Tremblay B. P. Kennedy Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene Science 1999 283 1544 1548
8. J. M. Friedman Leptin, leptin receptors, and the control of body weight Nutr. Rev. 1998 56 s38 s46
9. J. M. Zabolotny K. K. Bence-Hanulec A. Stricker-Krongrad F. Haj Y. Wang Y. Minokoshi Y. B. Kim J. K. Elmquist L. A. Tartaglia B. B. Kahn B. G. Neel PTP1B regulates leptin signal transduction in vivo Dev. Cell 2002 2 489 495
10. M. P. Myers J. N. Andersen A. Cheng M. L. Tremblay C. M. Horvath J. P. Parisien A. Salmeen D. Barford N. K. Tonks TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B J. Biol. Chem. 2001 276 47771 47774 10.1074/jbc.C100583200
11. T. A. Woodford-Thomas J. D. Rhodes J. E. Dixon Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts J. Cell Biol. 1992 117 401 414
12. J. R. Wiener B. J. Kerns E. L. Harvey M. R. Conaway J. D. Iglehart A. Berchuck R. C. Bast, Jr. Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression J. Natl. Cancer Inst. 1994 86 372 378
13. S. G. Julien N. Dube M. Read J. Penney M. Paquet Y. Han B. P. Kennedy W. J. Muller M. L. Tremblay Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis Nat. Genet. 2007 39 338 346 10.1038/ng1963
14. K. K. Balavenkatraman N. Aceto A. Britschgi U. Mueller K. K. Bence B. G. Neel M. Bentires-Alj Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance Mol. Cancer Res. 2011 9 1377 1384 10.1158/1541-7786.MCR-11-0198
15. N. Aceto M. Bentires-Alj Targeting protein-tyrosine phosphatases in breast cancer OncoTargets Ther. 2012 3 514 515
16. D. L. Lohse J. M. Denu N. Santoro J. E. Dixon Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1 Biochemistry 1997 36 4568 4575 10.1021/bi963094r
17. D. Bandyopadhyay A. Kusari K. A. Kenner F. Liu J. Chernoff T. A. Gustafson J. Kusari Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin J. Biol. Chem. 1997 272 1639 1645
18. S. Dadke S. Cotteret S. C. Yip Z. M. Jaffer F. Haj A. Ivanov F. Rauscher, 3rd K. Shuai T. Ng B. G. Neel J. Chernoff Regulation of protein tyrosine phosphatase 1B by sumoylation Nat. Cell Biol. 2007 9 80 85 10.1038/ncb1522
19. A. M. Bilwes J. den Hertog T. Hunter J. P. Noel Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization Nature 1996 382 555 559 10.1038/382555a0
20. D. L. Brautigan P. Bornstein B. Gallis Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn J. Biol. Chem. 1981 256 6519 6522
21. W. Maret C. Jacob B. L. Vallee E. H. Fischer Inhibitory sites in enzymes: zinc removal and reactivation by thionein Proc. Natl. Acad. Sci. U. S. A. 1999 96 1936 1940
22. H. Haase W. Maret Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling Exp. Cell Res. 2003 291 289 298 10.1016/S0014-4827(03)00406-3
23. M. Wilson C. Hogstrand W. Maret Picomolar concentrations of free zinc(ii) ions regulate receptor protein-tyrosine phosphatase beta activity J. Biol. Chem. 2012 287 9322 9326 10.1074/jbc.C111.320796
24. A. Krezel W. Maret Zinc-buffering capacity of a eukaryotic cell at physiological pZn JBIC, J. Biol. Inorg. Chem. 2006 11 1049 1062 10.1007/s00775-006-0150-5
25. 2+ homeostasis Nat. Methods 2009 6 737 740 10.1038/nmeth.1368
26. D. M. Bers C. W. Patton R. Nuccitelli A practical guide to the preparation of Ca(2+) buffers Methods Cell Biol. 2010 99 1 26 10.1016/B978-0-12-374841-6.00001-3
27. T. Zor Z. Selinger Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies Anal. Biochem. 1996 236 302 308 10.1006/abio.1996.0171
28. L. Shrodinger, 1.3r1 edn, 2010
29. I. W. Davis A. Leaver-Fay V. B. Chen J. N. Block G. J. Kapral X. Wang L. W. Murray W. B. Arendall, 3rd J. Snoeyink J. S. Richardson D. C. Richardson MolProbity: all-atom contacts and structure validation for proteins and nucleic acids Nucleic Acids Res. 2007 35 W375 W383 10.1093/nar/gkm216
30. O. Korb T. Stutzle T. E. Exner Empirical scoring functions for advanced protein-ligand docking with PLANTS J. Chem. Inf. Model. 2009 49 84 96 10.1021/ci800298z
31. M. Laitaoja J. Valjakka J. Janis Zinc coordination spheres in protein structures Inorg. Chem. 2013 52 10983 10991 10.1021/ic401072d
32. C. Andreini I. Bertini G. Cavallaro Minimal functional sites allow a classification of zinc sites in proteins PLoS One 2011 6 e26325 10.1371/journal.pone.0026325
33. G. H. Peters S. Branner K. B. Moller J. N. Andersen N. P. Moller Enzyme kinetic characterization of protein tyrosine phosphatases Biochimie 2003 85 527 534
34. J. Montalibet K. I. Skorey B. P. Kennedy Protein tyrosine phosphatase: enzymatic assays Methods 2005 35 2 8 10.1016/j.ymeth.2004.07.002
35. A. Krezel W. Maret Thionein/metallothionein control Zn(ii) availability and the activity of enzymes JBIC, J. Biol. Inorg. Chem. 2008 13 401 409 10.1007/s00775-007-0330-y
36. A. Krezel W. Maret Dual nanomolar and picomolar Zn(II) binding properties of metallothionein J. Am. Chem. Soc. 2007 129 10911 10921 10.1021/ja071979s
37. D. L. Rabenstein R. J. Kula Ligand-exchange kinetics and solution equilibriums of cadmium, zinc, and lead nitrilotriacetate complexes J. Am. Chem. Soc. 1969 91 2492 2503 10.1021/ja01038a017
38. 2+ binding by the phytochelatin (gamma-Glu-Cys)4-Gly and its precursor glutathione Anal. Biochem. 2008 375 82 89 10.1016/j.ab.2008.01.008
39. A. Krezel R. Latajka G. D. Bujacz W. Bal Coordination properties of tris(2-carboxyethyl)phosphine, a newly introduced thiol reductant, and its oxide Inorg. Chem. 2003 42 1994 2003 10.1021/ic025969y
40. H. M. Berman J. Westbrook Z. Feng G. Gilliland T. N. Bhat H. Weissig I. N. Shindyalov P. E. Bourne The Protein Data Bank Nucleic Acids Res. 2000 28 235 242
41. E. Ferrari M. Tinti S. Costa S. Corallino A. P. Nardozza A. Chatraryamontri A. Ceol G. Cesareni L. Castagnoli Identification of new substrates of the protein-tyrosine phosphatase PTP1B by Bayesian integration of proteome evidence J. Biol. Chem. 2011 286 4173 4185 10.1074/jbc.M110.157420
42. A. J. Barr Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development Future Med. Chem. 2010 2 1563 1576 10.4155/fmc.10.241
43. R. L. Khandelwal S. Pugazhenthi In vivo effects of vanadate on hepatic glycogen metabolizing and lipogenic enzymes in insulin-dependent and insulin-resistant diabetic animals Mol. Cell. Biochem. 1995 153 87 94
44. M. J. Gresser and A. S. Tracey, Vanadium in Biological Systems, Kluwer Academic Publishers, Netherlands, 1990
45. J. M. Samet R. Silbajoris W. Wu L. M. Graves Tyrosine phosphatases as targets in metal-induced signaling in human airway epithelial cells Am. J. Respir. Cell Mol. Biol. 1999 21 357 364 10.1165/ajrcmb.21.3.3656
46. R. A. Bozym R. B. Thompson A. K. Stoddard C. A. Fierke Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor ACS Chem. Biol. 2006 1 103 111 10.1021/cb500043a
47. J. L. Vinkenborg M. S. Koay M. Merkx Fluorescent imaging of transition metal homeostasis using genetically encoded sensors Curr. Opin. Chem. Biol. 2010 14 231 237 10.1016/j.cbpa.2009.11.022
48. S. Welte K. H. Baringhaus W. Schmider G. Muller S. Petry N. Tennagels 6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases Anal. Biochem. 2005 338 32 38 10.1016/j.ab.2004.11.047
49. T. A. Brandao A. C. Hengge S. J. Johnson Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps J. Biol. Chem. 2010 285 15874 15883 10.1074/jbc.M109.066951
50. S. K. Whittier A. C. Hengge J. P. Loria Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases Science 2013 341 899 903 10.1126/science.1241735
51. I. Anderie I. Schulz A. Schmid Characterization of the C-terminal ER membrane anchor of PTP1B Exp. Cell Res. 2007 313 3189 3197 10.1016/j.yexcr.2007. 05.025
52. T. Fukada T. Kambe Molecular and genetic features of zinc transporters in physiology and pathogenesis Metallomics 2011 3 662 674 10.1039/c1mt00011j
53. K. M. Taylor S. Hiscox R. I. Nicholson C. Hogstrand P. Kille Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7 Sci. Signaling 2012 5 ra11 10.1126/scisignal.2002585
54. H. Haase W. Maret Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases J. Trace Elem. Med. Biol. 2005 19 37 42 10.1016/j.jtemb.2005.02.004
55. E. A. Bellomo G. Meur G. A. Rutter Glucose regulates free cytosolic Zn(2)(+) concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet beta-cells J. Biol. Chem. 2011 286 25778 25789 10.1074/jbc.M111.246082
56. R. Fernandez-Ruiz E. Vieira P. M. Garcia-Roves R. Gomis Protein Tyrosine Phosphatase-1B Modulates Pancreatic beta-cell Mass PLoS One 2014 9 e90344 10.1371/journal.pone.0090344
57. A. J. Barr E. Ugochukwu W. H. Lee O. N. King P. Filippakopoulos I. Alfano P. Savitsky N. A. Burgess-Brown S. Muller S. Knapp Large-scale structural analysis of the classical human protein tyrosine phosphatome Cell 2009 136 352 363 10.1016/j.cell.2008.11.038
58. W. Maret Inhibitory zinc sites in enzymes BioMetals 2013 26 197 204 10.1007/s10534-013-9613-7
59. A. G. Daniel E. J. Peterson N. P. Farrell The bioinorganic chemistry of apoptosis: potential inhibitory zinc binding sites in caspase-3 Angew. Chem. 2014 53 4098 4101 10.1002/anie.201311114