A comparison of cytotoxicity and oxidative stress from welding fumes generated with a new nickel-, copper-based consumable versus mild and stainless steel-based welding in RAW 264.7 mouse macrophages

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Badding, Melissa A ^a   Fix, Natalie R ^a   Antonini, James M ^a   Leonard, Stephen S ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; CHROMIUM; COPPER; CYTOKINE; IRON; MANGANESE; NICKEL; POTASSIUM; REACTIVE OXYGEN METABOLITE; STAINLESS STEEL; TITANIUM; AUTACOID; SMOKE;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL DEATH; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PHAGOCYTE DYSFUNCTION; SOLUBILITY; WELDING; WELDING FUME; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECTS; ELECTRON SPIN RESONANCE; ENERGY METABOLISM; EXPOSURE; INTRACELLULAR SPACE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHAGOCYTOSIS; SMOKE; TOXICITY;

ANIMALS; CELL DEATH; CELL SURVIVAL; COPPER; CYTOKINES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENERGY METABOLISM; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; INTRACELLULAR SPACE; MACROPHAGES; MICE; MITOCHONDRIA; NICKEL; OXIDATIVE STRESS; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; SMOKE; STAINLESS STEEL; WELDING;

EID: 84903640446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101310     Document Type: Article

References (68)

1. Antonini JM, Lewis AB, Roberts JR, Whaley DA (2003) Pulmonary effects of welding fumes: Review of worker and experimental animal studies. Am J Ind Med 43: 350-360.
2. Hannu T, Piipari R, Kasurinen H, Keskinen H, Tuppurainen M, et al. (2005) Occupational asthma due to manual metal-arc welding of special stainless steels. Eur Respir J 26: 736-739.
3. Contreras GR, Chan-Yeung M (1997) Bronchial reactions to exposure to welding fumes. Occup Environ Med 54: 836-839.
4. Becker N (1999) Cancer mortality among arc welders exposed to fumes containing chromium and nickel. Results of a third follow-up: 1989-1995. J Occup Environ Med 41: 294-303.
5. Moulin JJ (1997) A meta-analysis of epidemiologic studies of lung cancer in welders. Scand J Work Environ Health 23: 104-113.
6. Zeidler-Erdely PC, Meighan TG, Erdely A, Battelli LA, Kashon ML, et al. (2013) Lung tumor promotion by chromium-containing welding particulate matter in a mouse model. Part Fibre Toxicol 10: 45.
7. Antonini JM, Lawryk NJ, Murthy GG, Brain JD (1999) Effect of welding fume solubility on lung macrophage viability and function in vitro. J Toxicol Environ Health A 58: 343-363.
8. Antonini JM, Leonard SS, Roberts JR, Solano-Lopez C, Young SH, et al. (2005) Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction. Mol Cell Biochem 279: 17-23.
9. Sriram K, Lin GX, Jefferson AM, Roberts JR, Wirth O, et al. (2010) Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. FASEB J 24: 4989-5002.
10. Antonini JM, Santamaria AB, Jenkins NT, Albini E, Lucchini R (2006) Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects. Neurotoxicology 27: 304-310.
11. Halatek T, Sinczuk-Walczak H, Szymczak M, Rydzynski K (2005) Neurological and respiratory symptoms in shipyard welders exposed to manganese. Int JOccup Med Environ Health 18: 265-274.
12. Antonini JM, Zeidler-Erdely PC, Young SH, Roberts JR, Erdely A (2012) Systemic immune cell response in rats after pulmonary exposure to manganese-containing particles collected from welding aerosols. J Immunotoxicol 9: 184-192.
13. Hansen K, Stern RM (1983) In vitro toxicity and transformation potency of nickel compounds. Environ Health Persp 51: 223-226.
14. Hansen K, Stern RM (1984) Toxicity and transformation potency of nickel compounds in BHK cells in vitro. IARC Sci Publ: 193-200.
15. Sowards JW, Liang D, Alexandrov BT, Frankel GS, Lippold JC (2011) A new chromium-free welding consumable for joining austenitic stainless steels. Weld J 90.
16. Leonard SS, Chen BT, Stone SG, Schwegler-Berry D, Kenyon AJ, et al. (2010) Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species. Part Fibre Toxicol 7: 32.
17. NIOSH (2010) NIOSH Analytical Methods Manual. 5th Edition, Method 7605, Hexavalent chromium by ion chromatography. Available: http://www.cdc.gov/niosh/ nmam/default.html.
18. NIOSH (1994) Elements (ICP): Method 7300. In NIOSH Manual of Analytical Methods. 4th Edition, Issue 2, U.S. Department of Health and Human Services, Publication No. 98-119. Washington, DC: NIOSH.
19. Halliwell B, Gutteridge JM (2007) Free Radicals in Biology and Medicine. Oxford, UK: Oxford University Press.
20. 4 mediates cellular responses via reactive oxygen species. Mol Cell Biochem 255: 171-179.
21. Ye J, Wang S, Leonard SS, Sun Y, Butterworth L, et al. (1999) Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis. J Biol Chem 274: 34974-34980.
22. Zhang Z, Leonard SS, Wang S, Vallyathan V, Castranova V, et al. (2001) Cr (VI) induces cell growth arrest through hydrogen peroxide-mediated reactions. Mol Cell Biochem 222: 77-83.
23. Msiska Z, Pacurari M, Mishra A, Leonard SS, Castranova V, et al. (2010) DNA double-strand breaks by asbestos, silica, and titanium dioxide: Possible biomarker of carcinogenic potential? Am J Resp Cell Mol Biol 43: 210-219.
24. Stefaniak AB, Harvey CJ, Bukowski VC, Leonard SS (2010) Comparison of free radical generation by pre- and post-sintered cemented carbide particles. J Occup Environ Hyg 7: 23-34.
25. Leonard SS, Xia C, Jiang BH, Stinefelt B, Klandorf H, et al. (2003) Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun 309: 1017-1026.
26. Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9: 671-675.
27. Dranka BP, Hill BG, Darley-Usmar VM (2010) Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free Radical Bio Med 48: 905-914.
28. Módis K, Gero{combining double acute accent} D, Erdélyi K, Szoleczky P, DeWitt D, et al. (2012) Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress. Biochem Pharmacol 83: 633-643.
29. Antonini JM, Roberts JR (2007) Chromium in stainless steel welding fume suppresses lung defense responses against bacterial infection in rats. J Immunotoxicol 4: 117-127.
30. Leonard SS, Hogans VJ, Coppes-Petricorena Z, Peer CJ, Vining TA, et al. (2010) Analysis of free-radical scavenging of Yerba Mate (Ilex paraguriensis) using electron spin resonance and radical-induced DNA damage. J Food Sci 75: C14-C20.
31. 4 and related DNA damage. Mol Cell Biochem 234-235: 309-315.
32. Ostling O, Johanson KJ (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commun 123: 291-298.
33. Fairbairn DW, Olive PL, O'Neill KL (1995) The comet assay: A comprehensive review. Mutat Res 339: 37-59.
34. Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, et al. (2011) Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats. Arch Toxicol 85: 487-498.
35. Zeidler-Erdely PC, Battelli LA, Stone S, Chen BT, Frazer DG, et al. (2011) Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice. Inhal Toxicol 23: 112-120.
36. Antonini JM, Roberts JR, Schwegler-Berry D, Mercer RR (2013) Comparative microscopic study of human and rat lungs after overexposure to welding fume. Ann Occup Hyg 57: 1167-1179.
37. Antonini JM, Stone S, Roberts JR, Chen B, Schwegler-Berry D, et al. (2007) Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats. Toxicol Appl Pharm 223: 234-245.
38. Erdely A, Hulderman T, Salmen-Muniz R, Liston A, Zeidler-Erdely PC, et al. (2011) Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice. Toxicol Lett 204: 12-16.
39. Erdely A, Salmen-Muniz R, Liston A, Hulderman T, Zeidler-Erdely PC, et al. (2011) Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter. Toxicology 287: 153-159.
40. Antonini JM, Taylor MD, Zimmer AT, Roberts JR (2004) Pulmonary responses to welding fumes: Role of metal constituents. J Toxicol Environ Health A 67: 233-249.
41. Antonini JM, Clarke RW, Krishna Murthy GG, Sreekanthan P, Jenkins N, et al. (1998) Freshly generated stainless steel welding fume induces greater lung inflammation in rats as compared to aged fume. Toxicol Lett 98: 77-86.
42. Antonini JM, Krishna Murthy GG, Rogers RA, Albert R, Ulrich GD, et al. (1996) Pneumotoxicity and pulmonary clearance of different welding fumes after intratracheal instillation in the rat. Toxicol Appl Pharm 140: 188-199.
43. Antonini JM, Krishna Murthy GG, Brain JD (1997) Responses to welding fumes: lung injury, inflammation, and the release of tumor necrosis factor-α and interleukin-1β. Exp Lung Res 23: 205-227.
44. Zeidler-Erdely PC, Kashon ML, Battelli LA, Young SH, Erdely A, et al. (2008) Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. Part Fibre Toxicol 5: 12.
45. Leonard SS, Harris GK, Shi X (2004) Metal-induced oxidative stress and signal transduction. Free Radical Biol Med 37: 1921-1942.
46. Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283: 65-87.
47. Dreher KL, Jaskot RH, Lehmann JR, Richards JH, McGee JK, et al. (1997) Soluble transition metals mediate residual oil fly ash induced acute lung injury. J Toxicol Environ Health 50: 285-305.
48. Valavanidis A, Fiotakis K, Vlachogianni T (2008) Airborne particulate matter and human health: Toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J Environ Sci Health, Part C 26: 339-362.
49. Han J-Y, Takeshita K, Utsumi H (2001) Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles. Free Radical Bio Med 30: 516-525.
50. Capasso L, Camatini M, Gualtieri M (2014) Nickel oxide nanoparticles induce inflammation and genotoxic effect in lung epithelial cells. Toxicol Lett.
51. Volke A, Rünkorg K, Wegener G, Vasar E, Volke V (2013) Dual effect of nickel on L-arginine/nitric oxide system in RAW 264.7 macrophages. Int Immunopharm 15: 511-516.
52. Ahamed M, Siddiqui MA, Akhtar MJ, Ahmad I, Pant AB, et al. (2010) Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells. Biochem Biophys Res Commun 396: 578-583.
53. Fahmy B, Cormier SA (2009) Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicol in Vitro 23: 1365-1371.
54. Gurr J-R, Wang ASS, Chen C-H, Jan K-Y (2005) Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213: 66-73.
55. Park E-J, Yi J, Chung K-H, Ryu D-Y, Choi J, et al. (2008) Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol Lett 180: 222-229.
56. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, et al. (2000) Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35: 206-221.
57. Henderson L, Wolfreys A, Fedyk J, Bourner C, Windebank S (1998) The ability of the Comet assay to discriminate between genotoxins and cytotoxins. Mutagenesis 13: 89-94.
58. Kawanishi S, Inoue S, Oikawa S, Yamashita N, Toyokuni S, et al. (2001) Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds. Free Radical Bio Med 31: 108-116.
59. Kasprzak KS, Hernandez L (1989) Enhancement of hydroxylation and deglycosylation of 2′-deoxyguanosine by carcinogenic nickel compounds. Cancer Res 49: 5964-5968.
60. Tkeshelashvili LK, Reid TM, McBride TJ, Loeb LA (1993) Nickel induces a signature mutation for oxygen free radical damage. Cancer Res 53: 4172-4174.
61. Pryor WA (1992) Biological effects of cigarette smoke, wood smoke, and the smoke from plastics: the use of electron spin resonance. Free Radical Biol Med 13: 659-676.
62. Shusterman DJ (1993) Polymer fume fever and other fluorocarbon pyrolysis-related syndromes. Occup Med 8: 519-531.
63. Renwick LC, Donaldson K, Clouter A (2001) Impairment of alveolar macrophage phagocytosis by ultrafine particles. Toxicol Appl Pharm 172: 119-127.
64. Lundborg M, Dahlen SE, Johard U, Gerde P, Jarstrand C, et al. (2006) Aggregates of ultrafine particles impair phagocytosis of microorganisms by human alveolar macrophages. Environ Res 100: 197-204.
65. Zhou H, Kobzik L (2007) Effect of concentrated ambient particles on macrophage phagocytosis and killing of Streptococcus pneumoniae. Am J Resp Cell Mol Biol 36: 460-465.
66. Yin XJ, Dong CC, Ma JY, Roberts JR, Antonini JM, et al. (2007) Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by the organic component of diesel exhaust particles. J Toxicol Environ Health A 70: 820-828.
67. Hooftman RN, Arkesteyn CW, Roza P (1988) Cytotoxicity of some types of welding fume particles to bovine alveolar macrophages. Ann Occup Hyg 32: 95-102.
68. Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, et al. (2009) Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats. Inhal Toxicol 21: 182-192.