Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: A randomized controlled clinical trial

Journal of Obstetrics and Gynaecology Research

Volumn 40, Issue 4, 2014, Pages 1067-1076

  Ebrahimi Mamaghani, Mehranghiz ^a   Saghafi Asl, Maryam ^b   Pirouzpanah, Saeed ^b   Asghari Jafarabadi, Mohammad ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Blood glucose; Diabetes; Lipid profile; Onion; Polycystic ovary syndrome

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYPROGESTERONE; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROGESTERONE; PROLACTIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FOLLICULAR PHASE; GLUCOSE BLOOD LEVEL; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; OBESITY; ONION; OVARY POLYCYSTIC DISEASE; PROGESTERONE BLOOD LEVEL; PROLACTIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RAW FOOD; TRIACYLGLYCEROL BLOOD LEVEL; ADOLESCENT; BLOOD; COMPLICATION; DIET THERAPY; FUNCTIONAL FOOD; HYPERCHOLESTEROLEMIA; IRAN; PATHOPHYSIOLOGY; PLANT ROOT; SINGLE BLIND PROCEDURE; YOUNG ADULT;

ADOLESCENT; ADULT; BODY MASS INDEX; FEMALE; FUNCTIONAL FOOD; HUMANS; HYPERCHOLESTEROLEMIA; IRAN; OBESITY; ONIONS; OVERWEIGHT; PLANT ROOTS; POLYCYSTIC OVARY SYNDROME; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84903639335     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/jog.12311     Document Type: Article

References (38)

1. Goldenberg N, Glueck C. Medical therapy in women with polycystic ovary syndrome before and during pregnancy and lactation. Minerva Ginecol 2008; 60: 63-75.
2. Dokras A, Bochner M, Hollinrake E, Markham S, VanVoorhis B, Jagasia DH. Screening women with polycystic ovary syndrome for metabolic syndrome. Obstet Gynecol 2005; 106: 131-137.
3. Diamanti-Kandarakis E, Kouli C, Tsianateli T, Bergiele A. Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome. Eur J Endocrinol 1998; 138: 269-274.
4. Legro R, Kunselman A, Dunaif A. Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome. Am J Med 2001; 111: 607-613.
5. Diamanti-Kandarakis E, Papavassiliou AG, Kandarakis SA, Chrousos GP. Pathophysiology and types of dyslipidemia in PCOS. Trends Endocrinol Metab 2007; 18: 280-285.
6. Rajkhowa M, Neary R, Kumpatla P et al. Altered composition of high density lipoproteins in women with the polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82: 3389-3394.
7. Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD. The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 2008; 93: 3373-3380.
8. Elkind-Hirsch K. Thiazolidinediones for the therapeutic management of polycystic ovary syndrome: Impact on metabolic and reproductive abnormalities. Treat Endocrinol 2006; 5: 171-187.
9. Griffiths G, Trueman L, Crowther T, Thomas B, Smith B. Onions-a global benefit to health. Phytother Res 2002; 16: 603-615.
10. Bang M, Kim H-A, Cho Y-J. Alterations in the blood glucose, serum lipids and renal oxidative stress in diabetic rats by supplementation of onion (Allium cepa. Linn). Nutr Res Pract 2009; 3: 242-246.
11. Hwang H-J. Effect of onion powder supplementation on lipid metabolism in high fat-cholesterol fed SD Rats. J Food Sci Nutr 2008; 13: 71-76.
12. Kumari K, Augusti K. Antidiabetic effects of Smethylcysteine sulphoxide on alloxan diabetes. Planta Med 1995; 61: 72-74.
13. Kumari K, Augusti K. Lipid lowering effect of S-methyl cysteine sulfoxide from Allium cepa Linn in high cholesterol diet fed rats. J Ethnopharmacol 2007; 109: 367-371.
14. Kumari K, Mathew BC, Augusti K. Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J Biochem Biophys 1995; 32: 49-51.
15. Sharma K, Chowdhury N, Sharma A, Misra M. Studies on hypocholestraemic activity of onion. I. Effect of serum cholesterol in alimentary lipaemia in man. Indian J Nutr Diet 1975; 12: 288-291.
16. Steiner M, Khan AH, Holbert D, Lin R. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 1996; 64: 866-870.
17. Tjokroprawiro A, Pikir B, Budhiarta A et al. Metabolic effects of onion and green beans on diabetic patients. Tohoku J Exp Med 1983; 141 (Suppl): 671-676.
18. Jelodar GA, Maleki M, Motadayen M, Sirus S. Effect of fenugreek, onion and garlic on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats. Indian J Med Sci 2005; 59: 64-69.
19. Gabler NK, Ostrowska E, Sterling SJ et al. Consumption of raw brown onions variably modulate plasma lipid profile and lipoprotein oxidation in pigs fed a high-fat diet. J Sci Food Agr 2005; 85: 154-160.
20. Sharma K, Gupta R, Gupta S, Samuel K. Antihyperglycemic effect of onion: Effect on fasting blood sugar and induced hyperglycemia in man. Indian J Med Res 1977; 65: 422-429.
21. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41-47.
22. Kumarapeli V, Seneviratne R, Wijeyaratne C, Yapa R, Dodampahala S. A simple screening approach for assessing community prevalence and phenotype of polycystic ovary syndrome in a semi-urban population in Sri Lanka. Am J Epidemiol 2008; 168: 321-328.
23. Balen A, Laven J, Tan S, Dewailly D. Ultrasound assessment of the polycystic ovary: International consensus definitions. Hum Reprod Update 2003; 9: 505-514.
24. Rezayian F. Relationship of Folate and Vitamin B12 Intake with Breast Cancer Risk: A Case-Control Study. Tehran: Shaheed Beheshti University of Medical Sciences, 2010.
25. Chobanian AV, Bakris GL, Black HR et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003; 42: 1206-1252.
26. Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: A double-blind trial. Eur Rev Med Pharmacol Sci 2009; 13: 105-110.
27. Carmina E. Prevalence of idiopathic hirsutism. Eur J Endocrinol 1998; 139: 421-423.
28. Tziomalos K, Katsikis I, Papadakis E, Kandaraki EA, Macut D, Panidis D. Comparison of markers of insulin resistance and circulating androgens between women with polycystic ovary syndrome and women with metabolic syndrome. Hum Reprod 2013; 28: 785-793.
29. Gabler N, Osrowska E, Imsic M et al. Dietary onion intake as part of a typical high fat diet improves indices of cardiovascular health using the mixed sex pig model. Plant Foods Hum Nutr 2006; 61: 179-185.
30. Medvedeva I, Pufacheva T, Dorodneva E. Influence of glucose control on the main parameters of serum lipid profile and platelet membranes in patients with metabolic syndrome and type 2 diabetes mellitus. Atheroscler Suppl 2002; 3: 163.
31. Islam M, Choi H, Loots D. Effects of dietary onion (Allium cepa L.) in a high-fat diet streptozotocin-induced diabetes rodent model. Ann Nutr Metab 2008; 53: 6-12.
32. Gabler N, Ostrowska E, Jones R et al. (eds). Consumption of Brown Onion (Allium Cepa) Cultivars Reduce the Risk Factors of Cardiovascular Disease. Australian Postharvest Horticulture Conference. Brisbane: Department of Primary Industries, Queensland Government, 2003.
33. O'Brien KD, Brehm BJ, Seeley RJ et al. Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects. J Clin Endocrinol Metab 2005; 90: 2244-2249.
34. Wood PD, Stefanick ML, Dreon DM et al. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med 1988; 319: 1173-1179.
35. Folsom AR, Qamhieh HT, Wing RR et al. Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults. Arterioscler Thromb Vasc Biol 1993; 13: 162-169.
36. Andersen P, Seljeflot I, Abdelnoor M et al. Increased insulin sensitivity and fibrinolytic capacity after dietary intervention in obese women with polycystic ovary syndrome. Metabolism 1995; 44: 611-616.
37. Glueck C, Wang P, Fontaine R, Tracy T, Sieve-Smith L. Metformin to restore normal menses in oligo-amenorrheic teenage girls with polycystic ovary syndrome (PCOS). J Adolesc Health 2001; 29: 160-169.
38. Jain R, Sachdev K. A note on hypoglycemic action of onion in diabetes. Curr Med Pract 1971; 15: 901-902.