Uterus allotransplantation in cynomolgus macaque: A preliminary experience with non-human primate models

Journal of Obstetrics and Gynaecology Research

Volumn 40, Issue 4, 2014, Pages 907-918

  Kisu, Iori ^a   Mihara, Makoto ^b   Banno, Kouji ^a   Hara, Hisako ^b   Masugi, Yohei ^a   Araki, Jun ^b   Iida, Takuya ^b   Yamada, Yohei ^c   Kato, Yojiro ^d   Shiina, Takashi ^e   Suganuma, Nobuhiko ^f   Aoki, Daisuke ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Department of Medicine   (United States)

^e TOKAI UNIVERSITY   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

Cynomolgus macaque; Immunosuppressants; Indocyanine green; Uterine factor infertility; Uterus transplantation

Indexed keywords

HEPARIN; INDOCYANINE GREEN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT;

ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; COLPOSCOPY; DRUG BLOOD LEVEL; ECHOGRAPHY; FEMALE; GRAFT REJECTION; MACACA FASCICULARIS; MENSTRUATION; NONHUMAN; PRIMATE MODEL; UTERINE CERVIX BIOPSY; UTERUS; UTERUS BLOOD FLOW; ANIMAL; COMPARATIVE STUDY; DRUG COMBINATION; IMMUNOLOGY; PHYSIOLOGY; TRANSPLANTATION;

ANIMALS; DRUG THERAPY, COMBINATION; FEMALE; GRAFT REJECTION; IMMUNOSUPPRESSIVE AGENTS; MACACA FASCICULARIS; MENSTRUATION; TRANSPLANTATION, HOMOLOGOUS; UTERUS;

EID: 84903635137     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/jog.12302     Document Type: Article

References (15)

1. Brinsden PR. Gestational surrogacy. Hum Reprod Update 2003; 9: 483-491.
2. Milliez J. Uterine transplantation FIGO Committee for the Ethical Aspects of Human Reproduction and Women's Health. Int J Gynaecol Obstet 2009; 106: 270.
3. Fageeh W, Raffa H, Jabbad H, Marzouki A. Transplantation of the human uterus. Int J Gynaecol Obstet 2002; 76: 245-251.
4. Kisu I, Banno K, Mihara M, Suganuma N, Aoki D. Current status of uterus transplantation in primates and issues for clinical application. Fertil Steril 2013; 100: 280-294.
5. Ozkan O, Erman Akar M, Ozkan O et al. Preliminary results of the first human uterus transplantation from a multiorgan donor. Fertil Steril 2013; 99: 470-476.e5.
6. Hansen A. Swedish surgeons report world's first uterus transplantations from mother to daughter. BMJ 2012; 345: e6357.
7. Diaz-Garcia C, Akhi SN, Wallin A, Pellicer A, Brännström M. First report on fertility after allogeneic uterus transplantation. Acta Obstet Gynecol Scand 2010; 89: 1491-1494.
8. Ramirez ER, Ramirez Nessetti DK, Nessetti MB et al. Pregnancy and outcome of uterine allotransplantation and assisted reproduction in sheep. J Minim Invasive Gynecol 2011; 18: 238-245.
9. Mihara M, Kisu I, Hara H et al. Uterine autotransplantation in cynomolgus macaques: The first case of pregnancy and delivery. Hum Reprod 2012; 27: 2332-2340.
10. Johannesson L, Enskog A, Mölne J et al. Preclinical report on allogeneic uterus transplantation in non-human primates. Hum Reprod 2013; 28: 189-198.
11. Kisu I, Mihara M, Banno K et al. A new surgical technique of uterine auto-transplantation in cynomolgus monkey: Preliminary report about two cases. Arch Gynecol Obstet 2012; 285: 129-137.
12. Mihara M, Kisu I, Hara H et al. Uterus autotransplantation in cynomolgus macaques: Intraoperative evaluation of uterine blood flow using indocyanine green. Hum Reprod 2011; 26: 3019-3027.
13. Del Priore G, Stega J, Sieunarine K, Ungar L, Smith Jr. Human uterus retrieval from a multi-organ donor. Obstet Gynecol 2007; 109: 101-104.
14. Wranning CA, Mölne J, El-Akouri RR, Kurlberg G, Brännström M. Short-term ischaemic storage of human uterine myometrium-basic studies towards uterine transplantation. Hum Reprod 2005; 20: 2736-2744.
15. Sieunarine K, Lindsay I, Ungar L, Del Priore G, Smith Jr. Cold ischaemic preservation of human uterine tissue. Int Surg 2008; 93: 366-372.