MicroRNAs in autoimmune diseases

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Qu, Zigang ^a   Li, Wenhui ^a   Fu, Baoquan ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 124; MICRORNA 126; MICRORNA 132; MICRORNA 143; MICRORNA 146A; MICRORNA 155; MICRORNA 192; MICRORNA 20A; MICRORNA 34A; MICRORNA 375; MITOCHONDRION ANTIBODY; MESSENGER RNA;

APOPTOSIS; AUTOIMMUNE DISEASE; AUTOPHAGY; CLINICAL RESEARCH; CROHN DISEASE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOMODULATION; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MICROARRAY ANALYSIS; MULTIPLE SCLEROSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIMARY BILIARY CIRRHOSIS; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; RISK FACTOR; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; ULCERATIVE COLITIS; AUTOIMMUNITY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; PATHOLOGY;

AUTOIMMUNE DISEASES; AUTOIMMUNITY; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INFLAMMATION; MICRORNAS; RNA, MESSENGER;

EID: 84903592166     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/527895     Document Type: Review

References (73)

1. Bartel D. P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004 116 2 281 297 2-s2.0-0347444723 10.1016/S0092-8674(04)00045-5 (Pubitemid 38167318)
2. Lee R. C., Feinbaum R. L., Ambros V., The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993 75 5 843 854 2-s2.0-0027751663 10.1016/0092-8674(93)90529-Y (Pubitemid 24014542)
3. Farh K. K. H., Grimson A., Jan C., Lewis B. P., Johnston W. K., Lim L. P., Burge C. B., Bartel D. P., The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science 2005 310 5755 1817 1821 2-s2.0-29144505309 10.1126/science.1121158 (Pubitemid 41814382)
4. Perera R. J., Ray A., MicroRNAs in the search for understanding human diseases. BioDrugs 2007 21 2 97 104 2-s2.0-34247245262 10.2165/00063030- 200721020-00004 (Pubitemid 46624554)
5. Eulalio A., Huntzinger E., Izaurralde E., Getting to the root of miRNA-mediated gene silencing. Cell 2008 132 1 9 14 2-s2.0-37648998629 10.1016/j.cell.2007.12.024
6. Ambros V., MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 2003 113 6 673 676 2-s2.0-0038343499 10.1016/S0092-8674(03)00428-8 (Pubitemid 36724931)
7. Ambros V., The functions of animal microRNAs. Nature 2004 431 7006 350 355 2-s2.0-4644309196 10.1038/nature02871 (Pubitemid 39265675)
8. Zhou X., Jeker L. T., Fife B. T., Zhu S., Anderson M. S., McManus M. T., Bluestone J. A., Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. Journal of Experimental Medicine 2008 205 9 1983 1991 2-s2.0-51049120236 10.1084/jem.20080707
9. Pauley K. M., Cha S., Chan E. K. L., MicroRNA in autoimmunity and autoimmune diseases. Journal of Autoimmunity 2009 32 3-4 189 194 2-s2.0-67349273027 10.1016/j.jaut.2009.02.012
10. Anaya J. M., Shoenfeld Y., Correa P. A., García-Carrasco M., Cervera R., Autoinmunidad y Enfermedad Autoinmune 2005 Medellín, Colombia CIB
11. Cooper G. S., Stroehla B. C., The epidemiology of autoimmune diseases. Autoimmunity Reviews 2003 2 3 119 125 2-s2.0-0141819043 10.1016/S1568-9972(03) 00006-5 (Pubitemid 37443848)
12. Klareskog L., Catrina A. I., Paget S., Rheumatoid arthritis. The Lancet 2009 373 9664 659 672 2-s2.0-60249090304 10.1016/S0140-6736(09)60008-8
13. Pauley K. M., Satoh M., Chan A. L., Bubb M. R., Reeves W. H., Chan E. K. L., Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Research and Therapy 2008 10 4, article R101 2-s2.0-52249094653 10.1186/ar2493
14. Stanczyk J., Leslie Pedrioli D. M., Brentano F., Sanchez-Pernaute O., Kolling C., Gay R. E., Detmar M., Gay S., Kyburz D., Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis and Rheumatism 2008 58 4 1001 1009 2-s2.0-42449156220 10.1002/art.23386 (Pubitemid 351564001)
15. Murata K., Yoshitomi H., Tanida S., Ishikawa M., Nishitani K., Ito H., Nakamura T., Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Research and Therapy 2010 12 3, article R86 2-s2.0-77952086523 10.1186/ar3013
16. + T cells from patients with rheumatoid arthritis. Arthritis Research and Therapy 2010 12 3, article R81 2-s2.0-77951973193 10.1186/ar3006
17. Niimoto T., Nakasa T., Ishikawa M., Okuhara A., Izumi B., Deie M., Suzuki O., Adachi N., Ochi M., MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. BMC Musculoskeletal Disorders 2010 11 article 209 2-s2.0-77956511013 10.1186/1471-2474-11-209
18. Niederer F., Trenkmann M., Ospelt C., Karouzakis E., Neidhart M., Stanczyk J., Kolling C., Gay R. E., Detmar M., Gay S., Jüngel A., Kyburz D., Down-regulation of microRNA-34a in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis & Rheumatology 2012 64 6 1771 1779 10.1002/art.34334
19. Nakamachi Y., Kawano S., Takenokuchi M., Nishimura K., Sakai Y., Chin T., Saura R., Kurosaka M., Kumagai S., MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis and Rheumatism 2009 60 5 1294 1304 2-s2.0-66049112958 10.1002/art.24475
20. Alsaleh G., Suffert G., Semaan N., Juncker T., Frenzel L., Gottenberg J. E., Sibilia J., Pfeffer S., Wachsmann D., Bruton's tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes. Journal of Immunology 2009 182 8 5088 5097 2-s2.0-65249088074 10.4049/jimmunol.0801613
21. Stanczyk J., Ospelt C., Karouzakis E., Filer A., Raza K., Kolling C., Gay R., Buckley C. D., Tak P. P., Gay S., Kyburz D., Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis and Rheumatism 2011 63 2 373 381 2-s2.0-79551655444 10.1002/art.30115
22. Long L., Yu P., Liu Y., Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis. Clinical and Developmental Immunology 2013 2013 10 296139 10.1155/2013/296139
23. Murata K., Furu M., Yoshitomi H., Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis. PLoS ONE 2013 8 7 e69118 10.1371/journal.pone.0069118
24. Miyaki S., Nakasa T., Otsuki S., Grogan S. P., Higashiyama R., Inoue A., Kato Y., Sato T., Lotz M. K., Asahara H., MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis and Rheumatism 2009 60 9 2723 2730 2-s2.0-69449103973 10.1002/art.24745
25. Xu T., Huang C., Chen Z., Li J., MicroRNA-323-3p: a new biomarker and potential therapeutic target for rheumatoid arthritis. Rheumatology International 2013 10.1007/s00296-013-2767-3
26. Adams K. F., Schatzkin A., Harris T. B., Kipnis V., Mouw T., Ballard-Barbash R., Hollenbeck A., Leitzmann M. F., Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. New England Journal of Medicine 2006 355 8 763 778 2-s2.0-33747870163 10.1056/NEJMoa055643 (Pubitemid 44285582)
27. Shaw J. E., Sicree R. A., Zimmet P. Z., Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice 2010 87 1 4 14 2-s2.0-73749083481 10.1016/j.diabres.2009.10.007
28. Ilonen J., Akerblom H. K., New technologies and genetics of type 1 diabetes. Diabetes Technology & Therapeutics 1999 1 2 205 207 2-s2.0-0033140464
29. Poy M. N., Hausser J., Trajkovski M., Braun M., Collins S., Rorsman P., Zavolan M., Stoffel M., miR-375 maintains normal pancreatic α-and β -cell mass. Proceedings of the National Academy of Sciences of the United States of America 2009 106 14 5813 5818 2-s2.0-65249093130 10.1073/pnas.0810550106
30. Nielsen L. B., Wang C., Sørensen K., Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression. Experimental Diabetes Research 2012 2012 7 896362 10.1155/2012/896362
31. Compston A., Coles A., Multiple sclerosis. The Lancet 2008 372 9648 1502 1517 2-s2.0-54149084585 10.1016/S0140-6736(08)61620-7
32. Du C., Liu C., Kang J., Zhao G., Ye Z., Huang S., Li Z., Wu Z., Pei G., MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nature Immunology 2009 10 12 1252 1259 2-s2.0-70449716915 10.1038/ni.1798
33. Otaegui D., Baranzini S. E., Armañanzas R., Calvo B., Muñoz-Culla M., Khankhanian P., Inza I., Lozano J. A., Castillo-Triviño T., Asensio A., Olaskoaga J., Lopez de Munain A., Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS ONE 2009 4 7 2-s2.0-67651113615 10.1371/journal.pone.0006309 e6309
34. Keller A., Leidinger P., Lange J., Borries A., Schroers H., Scheffler M., Lenhof H. P., Ruprecht K., Meese E., Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS ONE 2009 4 10 e7440 2-s2.0-77149132365
35. Junker A., Krumbholz M., Eisele S., Mohan H., Augstein F., Bittner R., Lassmann H., Wekerle H., Hohlfeld R., Meinl E., MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 2009 132 12 3342 3352 2-s2.0-72649095061 10.1093/brain/awp300
36. Lindberg R. L. P., Hoffmann F., Kuhle J., Kappos L., Circulating microRNAs as indicators for disease course of multiple sclerosis. Multiple Sclerosis 2010 16 S41 S196
37. Sievers C., Hoffmann F., Fontoura P., Kappos L., Lindberg R. L. P., Effect of natalizumab on microRNA expression in B-lymphocytes of relapsing-remitting multiple sclerosis patients. Multiple Sclerosis 2010 16 197 352
38. de Santis G., Ferracin M., Biondani A., Caniatti L., Rosaria Tola M., Castellazzi M., Zagatti B., Battistini L., Borsellino G., Fainardi E., Gavioli R., Negrini M., Furlan R., Granieri E., Altered miRNA expression in T regulatory cells in course of multiple sclerosis. Journal of Neuroimmunology 2010 226 1-2 165 171 2-s2.0-77956343824 10.1016/j.jneuroim.2010.06.009
39. + lymphocytes of relapsing-remitting multiple sclerosis patients. European Journal of Immunology 2010 40 3 888 898 2-s2.0-77749260581 10.1002/eji.200940032
40. Nikolov N. P., Illei G. G., Pathogenesis of Sjögren's syndrome. Current Opinion in Rheumatology 2009 21 5 465 470 10.1097/BOR.0b013e32832eba21
41. Alevizos I., Bajracharya S. D., Alexander S., Turner R. J., Illei G. G., MicroRNA profiling of minor salivary glands identifies disease and inflammation biomarkers in Sjogren's syndrome patients. Arthritis & Rheumatism 2009 60 S733 S734
42. Pauley K. M., Stewart C. M., Gauna A. E., Dupre L. C., Kuklani R., Chan A. L., Pauley B. A., Reeves W. H., Chan E. K. L., Cha S., Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity. European Journal of Immunology 2011 41 7 2029 2039 2-s2.0-79959720798 10.1002/eji.201040757
43. D'Cruz D. P., Khamashta M. A., Hughes G. R., Systemic lupus erythematosus. The Lancet 2007 369 9561 587 596 2-s2.0-33846897631 10.1016/S0140-6736(07)60279-7 (Pubitemid 46241445)
44. Dai Y., Huang Y. S., Tang M., Lv T. Y., Hu C. X., Tan Y. H., Xu Z. M., Yin Y. B., Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus 2007 16 12 939 946 2-s2.0-37849031502 10.1177/0961203307084158
45. Tang Y., Luo X., Cui H., Ni X., Yuan M., Guo Y., Huang X., Zhou H., de Vries N., Tak P. P., Chen S., Shen N., MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis and Rheumatism 2009 60 4 1065 1075 2-s2.0-65249138193 10.1002/art.24436
46. Luo X., Yang W., Ye D. Q., Cui H., Zhang Y., Hirankarn N., Qian X., Tang Y., Lau Y. L., de Vries N., Tak P. P., Tsao B. P., Shen N., A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genetics 2011 7 6 2-s2.0-79959836816 10.1371/journal.pgen.1002128 e1002128
47. Deng Y., Zhao J., Sakurai D., MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genetics 2013 9 2 e1003336 10.1371/journal.pgen.1003336.
48. Stagakis E., Bertsias G., Verginis P., Nakou M., Hatziapostolou M., Kritikos H., Iliopoulos D., Boumpas D. T., Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: MiR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Annals of the Rheumatic Diseases 2011 70 8 1496 1506 2-s2.0-79959784552 10.1136/ard.2010.139857
49. Wang G., Tam L. S., Li E. K. M., Kwan B. C. H., Chow K. M., Luk C. C. W., Li P. K. T., Szeto C. C., Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus. Journal of Rheumatology 2010 37 12 2516 2522 2-s2.0-78649731017 10.3899/jrheum.100308
50. Te J. L., Dozmorov I. M., Guthridge J. M., Nguyen K. L., Cavett J. W., Kelly J. A., Bruner G. R., Harley J. B., Ojwang J. O., Identification of unique microRNA signature associated with lupus nephritis. PLoS ONE 2010 5 5 e10344 2-s2.0-77956291235 10.1371/journal.pone.0010344
51. + T cells by directly and indirectly targeting DNA methyltransferase 1. Journal of Immunology 2010 184 12 6773 6781 2-s2.0-77953624215 10.4049/jimmunol.0904060
52. + T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis and Rheumatism 2011 63 5 1376 1386 2-s2.0-79955569628 10.1002/art.30196
53. Yuan Y., Kasar S., Underbayev C., Role of microRNA-15a in autoantibody production in interferon-augmented murine model of lupus. Molecular Immunology 2012 52 2 61 70 10.1016/j.molimm.2012.04.007
54. Hanauer S. B., Inflammatory bowel disease. New England Journal of Medicine 1996 334 13 841 848 2-s2.0-0030000599 10.1056/NEJM199603283341307 (Pubitemid 26099608)
55. Sands B. E., From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology 2004 126 6 1518 1532 2-s2.0-2442613767 10.1053/j.gastro.2004.02.072 (Pubitemid 38649870)
56. Wu F., Guo N. J., Tian H., Marohn M., Gearhart S., Bayless T. M., Brant S. R., Kwon J. H., Peripheral blood MicroRNAs distinguish active ulcerative colitis and Crohn's disease. Inflammatory Bowel Diseases 2011 17 1 241 250 2-s2.0-78650119948 10.1002/ibd.21450
57. Zahm A. M., Thayu M., Hand N. J., Horner A., Leonard M. B., Friedman J. R., Circulating microRNA is a biomarker of pediatric crohn disease. Journal of Pediatric Gastroenterology and Nutrition 2011 53 1 26 33 2-s2.0-79959852640 10.1097/MPG.0b013e31822200cc
58. Paraskevi A., Theodoropoulos G., Papaconstantinou I., Mantzaris G., Nikiteas N., Gazouli M., Circulating MicroRNA in inflammatory bowel disease. Journal of Crohn's and Colitis 2012 6 9 900 904 2-s2.0-84857354394 10.1016/j.crohns.2012.02.006
59. Duttagupta R., DiRienzo S., Jiang R., Bowers J., Gollub J., Kao J., Kearney K., Rudolph D., Dawany N. B., Showe M. K., Stamato T., Getts R. C., Jones K. W., Genome-wide maps of circulating miRNA biomarkers for Ulcerative Colitis. PLoS ONE 2012 7 2 2-s2.0-84857135660 10.1371/journal.pone.0031241 e31241
60. Wu F., Zhang S., Dassopoulos T., Harris M. L., Bayless T. M., Meltzer S. J., Brant S. R., Kwon J. H., Identification of microRNAs associated with ileal and colonic Crohn's disease. Inflammatory Bowel Diseases 2010 16 10 1729 1738 2-s2.0-78649231641 10.1002/ibd.21267
61. Takagi T., Naito Y., Mizushima K., Hirata I., Yagi N., Tomatsuri N., Ando T., Oyamada Y., Isozaki Y., Hongo H., Uchiyama K., Handa O., Kokura S., Ichikawa H., Yoshikawa T., Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis. Journal of Gastroenterology and Hepatology 2010 25 1 S129 S133 2-s2.0-77951579490 10.1111/j.1440-1746.2009.06216.x
62. Bian Z., Li L., Cui J., Zhang H., Liu Y., Zhang C. Y., Zen K., Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis. Journal of Pathology 2011 225 4 544 553 2-s2.0-81255214942 10.1002/path.2907
63. Fasseu M., Tréton X., Guichard C., Pedruzzi E., Cazals-Hatem D., Richard C., Aparicio T., Daniel F., Soulé J. C., Moreau R., Bouhnik Y., Laburthe M., Groyer A., Ogier-Denis E., Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS ONE 2010 5 10 2-s2.0-78049340862 10.1371/journal.pone.0013160 e13160
64. Pekow J. R., Dougherty U., Mustafi R., Zhu H., Kocherginsky M., Rubin D. T., Hanauer S. B., Hart J., Chang E. B., Fichera A., Joseph L. J., Bissonnette M., MiR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. Inflammatory Bowel Diseases 2012 18 1 94 100 2-s2.0-83555161563 10.1002/ibd.21742
65. Nguyen H. T. T., Dalmasso G., Yan Y., Laroui H., Dahan S., Mayer L., Sitaraman S. V., Merlin D., MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation. Journal of Biological Chemistry 2010 285 2 1479 1489 2-s2.0-74049088187 10.1074/jbc.M109.057141
66. Brest P., Lapaquette P., Souidi M., Lebrigand K., Cesaro A., Vouret-Craviari V., Mari B., Barbry P., Mosnier J. F., Hébuterne X., Harel-Bellan A., Mograbi B., Darfeuille-Michaud A., Hofman P., A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nature Genetics 2011 43 3 242 245 2-s2.0-79952134938 10.1038/ng.762
67. Griffiths C. E., Barker J. N., Pathogenesis and clinical features of psoriasis. The Lancet 2007 370 9583 263 271 2-s2.0-34447539622 10.1016/S0140-6736(07)61128-3 (Pubitemid 47069537)
68. Sonkoly E., Wei T., Janson P. C. J., Sääf A., Lundeberg L., Tengvall-Linder M., Norstedt G., Alenius H., Homey B., Scheynius A., Ståhle M., Pivarcsi A., MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS ONE 2007 2 7, article e610 2-s2.0-77951233965
69. Sonkoly E., Ståhle M., Pivarcsi A., MicroRNAs: novel regulators in skin inflammation. Clinical and Experimental Dermatology 2008 33 3 312 315 2-s2.0-42249088885 10.1111/j.1365-2230.2008.02804.x (Pubitemid 351550660)
70. Wu L. S., Li F. F., Sun L. D., Li D., Su J., Kuang Y. H., Chen G., Chen X. P., Chen X., A miRNA-492 binding-site polymorphism in BSG (basigin) confers risk to psoriasis in Central South Chinese population. Human Genetics 2011 130 6 749 757 2-s2.0-82555189821 10.1007/s00439-011-1026-5
71. Selmi C., Bowlus C. L., Gershwin M. E., Coppel R. L., Primary biliary cirrhosis. The Lancet 2011 377 9777 1600 1609 2-s2.0-79955689227 10.1016/S0140-6736(10)61965-4
72. Padgett K. A., Lan R. Y., Leung P. C., Lleo A., Dawson K., Pfeiff J., Mao T. K., Coppel R. L., Ansari A. A., Gershwin M. E., Primary biliary cirrhosis is associated with altered hepatic microRNA expression. Journal of Autoimmunity 2009 32 3-4 246 253 2-s2.0-67349240835 10.1016/j.jaut.2009.02.022
73. Nurden A. T., Viallard J. F., Nurden P., New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura. The Lancet 2009 373 9674 1562 1569 2-s2.0-65349176604 10.1016/S0140-6736(09)60255-5