Intravenous tenecteplase in acute ischemic stroke: An updated review

Journal of Neurology

Volumn 261, Issue 6, 2014, Pages 1069-1072

  Behrouz, Réza ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Alteplase; Cerebrovascular disease; Pharmacology; Stroke; Tenecteplase; Thrombolysis; Thrombolytics; Tissue plasminogen activator

Indexed keywords

TENECTEPLASE; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

BRAIN ISCHEMIA; DRUG EFFICACY; DRUG SAFETY; HUMAN; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME; COMPLICATION; INTRAVENOUS DRUG ADMINISTRATION; ISCHEMIA; STROKE;

ADMINISTRATION, INTRAVENOUS; FIBRINOLYTIC AGENTS; HUMANS; ISCHEMIA; STROKE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84903582087     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-013-7102-0     Document Type: Review

References (18)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581-1588
2. Bluhmki E, Chamorro A, Dávalos A et al (2009) Stroke treatment with alteplase given 3.0-4.5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial. Lancet Neurol 8:1095-1102
3. The Ancrod Stroke Study Investigators (1994) Ancrod for the treatment of acute ischemic brain infarction. Stroke 25:1755-1759
4. Hennerici MG, Kay R, Bogousslavsky J, Lenzi GL, Verstraete M, Orgogozo JM, ESTAT Investigators (2006) Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial. Lancet 368:1871-1878
5. Hacke W, Albers G, Al-Rawi Y et al (2005) The desmoteplase in acute ischemic stroke trial (DIAS): a phase II MRI-based 9-h window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 36:66-73
6. Davydov L, Cheng JW (2001) Tenecteplase: a review. Clin Ther 23:982-997
7. Ross AM (1999) New plasminogen activators: a clinical review. Clin Cardiol 22:165-171
8. Van De Werf F, Adgey J, Ardissino D et al (1999) Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial. Lancet 354:716-722
9. Chapman DF, Lyden P, Lapchak PA, Nunez S, Thibodeaux H, Zivin J (2001) Comparison of TNK with wild-type tissue plasminogen activator in a rabbit embolic stroke model. Stroke 32:748-752
10. Haley EC Jr, Lyden PD, Johnston KC, Hemmen TM, TNK in Stroke Investigators (2005) A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke. Stroke. 36:607-612
11. Parsons MW, Miteff F, Bateman GA et al (2009) Acute ischemic stroke: imaging-guided tenecteplase treatment in an extended time window. Neurology 72:915-921
12. Haley EC Jr, Thompson JL, Grotta JC et al (2010) Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial. Stroke 41:707-711
13. Molina CA (2011) Reperfusion therapies for acute ischemic stroke: current pharmacological and mechanical approaches. Stroke 42:S16-S19
14. Parsons M, Spratt N, Bivard A et al (2012) A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med 366:1099-1107
15. González RG (2012) Tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med 367:275-276
16. ClinicalTrials.gov. TNK-tPA Evaluation for Minor Ischemic Stroke with Proven Occlusion (TEMPO-1). http://clinicaltrials.gov/ct2/show/NCT01654445?term= tenecteplase&rank=6
17. ClinicalTrials.gov. Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST). http://clinicaltrials.gov/ct2/show/NCT01472926?term= tenecteplase&rank=4
18. von Kummer R, Albers GW, Mori E, DIAS Steering Committees (2012) The desmoteplase in acute ischemic stroke (DIAS) clinical trial program. Int J Stroke 7:589-596