Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 307, Issue 1, 2014, Pages

  da Silva, Vanessa R ^a   Ralat, Maria A ^a   Quinlivan, Eoin P ^b   DeRatt, Barbara N ^a   Garrett, Timothy J ^b   Chi, Yueh Yun ^b   Frederik Nijhout, H ^c   Reed, Michael C ^c   Gregory III, Jesse F ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

Folate; Metabolite profile; One carbon; Vitamin B 6

Indexed keywords

BETAINE; CREATINE; CREATININE; CYSTATHIONINE; CYSTEINE; CYSTEINYLGLYCINE; GLUTATHIONE; PYRIDOXINE; TETRAHYDROFOLIC ACID; CARBON; FOLIC ACID;

ANIMAL CELL; ARTICLE; CARBON METABOLISM; CELL CULTURE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER TUMOR; MAMMAL CELL; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PYRIDOXINE DEFICIENCY; QUANTITATIVE STUDY; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENE TARGETING; METABOLISM; METABOLOME; SIGNAL TRANSDUCTION;

CARBON; COMPUTER SIMULATION; FOLIC ACID; GENE TARGETING; HEP G2 CELLS; HUMANS; METABOLOME; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; VITAMIN B 6 DEFICIENCY;

EID: 84903579712     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00697.2013     Document Type: Article

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