Autonomous motion and temperature-controlled drug delivery of Mg/Pt-poly(n -isopropylacrylamide) janus micromotors driven by simulated body fluid and blood plasma

ACS Applied Materials and Interfaces

Volumn 6, Issue 12, 2014, Pages 9897-9903

  Mou, Fangzhi ^a   Chen, Chuanrui ^a   Zhong, Qiang ^a   Yin, Yixia ^a   Ma, Huiru ^a   Guan, Jianguo ^a  

^a WUHAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

autonomous motion; blood plasma; body fluid; Janus particles; magnesium water reaction; micromotors; self propulsion

Indexed keywords

ACRYLIC MONOMERS; ANTIBODIES; BIOCERAMICS; BLOOD; BODY FLUIDS; CHEMICAL DETECTION; CHLORINE COMPOUNDS; CONTROLLED DRUG DELIVERY; HEAVY METALS; METAL IONS; PROPULSION; PROSTHETICS;

AUTONOMOUS MOTION; BLOOD PLASMA; JANUS PARTICLES; MAGNESIUM-WATER REACTION; SELF-PROPULSION;

MICROMOTORS;

ACRYLIC ACID RESIN; HYDROGEL; HYDROGEN; MAGNESIUM; PLATINUM; POLY-N-ISOPROPYLACRYLAMIDE; WATER;

BODY FLUID; CHEMISTRY; DRUG DELIVERY SYSTEM; HUMAN; HYDROGEL; PH; PLASMA; TEMPERATURE;

ACRYLIC RESINS; BODY FLUIDS; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEL; HYDROGEN; HYDROGEN-ION CONCENTRATION; MAGNESIUM; PLASMA; PLATINUM; TEMPERATURE; WATER;

EID: 84903540473     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/am502729y     Document Type: Article

References (40)

1. Schliwa, M.; Woehlke, G. Molecular Motors Nature 2003, 422, 759-765
2. Spudich, J. A. Molecular Motors, Beauty in Complexity Science 2011, 331, 1143-1144
3. Gao, W.; Wang, J. The Environmental Impact of Micro/Nanomachines: A Review ACS Nano 2014, 8, 3170-3180
4. Wang, W.; Duan, W.; Ahmed, S.; Mallouk, T. E.; Sen, A. Small Power: Autonomous Nano- and Micromotors Propelled by Self-Generated Gradients Nano Today 2013, 8, 531-554
5. Sengupta, S.; Ibele, M. E.; Sen, A. Fantastic Voyage: Designing Self-Powered Nanorobots Angew. Chem., Int. Ed. 2012, 51, 8434-8445
6. Ozin, G. A.; Manners, I.; Fournier-Bidoz, S.; Arsenault, A. Dream Nanomachines Adv. Mater. 2005, 17, 3011-3018
7. Wilson, D. A.; Nolte, R. J. M.; van Hest, J. C. M. Autonomous Movement of Platinum-Loaded Stomatocytes Nat. Chem. 2012, 4, 268-274
8. Wang, J.; Gao, W. Nano/Microscale Motors: Biomedical Opportunities and Challenges ACS Nano 2012, 6, 5745-5751
9. Sundararajan, S.; Lammert, P. E.; Zudans, A. W.; Crespi, V. H.; Sen, A. Catalytic Motors for Transport of Colloidal Cargo Nano Lett. 2008, 8, 1271-1276
10. Paxton, W. F.; Kistler, K. C.; Olmeda, C. C.; Sen, A.; St. Angelo, S. K.; Cao, Y.; Mallouk, T. E.; Lammert, P. E.; Crespi, V. H. Catalytic Nanomotors: Autonomous Movement of Striped Nanorods J. Am. Chem. Soc. 2004, 126, 13424-13431
11. Liu, R.; Sen, A. Autonomous Nanomotor Based on Copper-Platinum Segmented Nanobattery J. Am. Chem. Soc. 2011, 133, 20064-20067
12. Mou, F.; Chen, C.; Ma, H.; Yin, Y.; Wu, Q.; Guan, J. Self-Propelled Micromotors Driven by the Magnesium-Water Reaction and Their Hemolytic Properties Angew. Chem., Int. Ed. 2013, 52, 7208-7212
13. Howse, J. R.; Jones, R. A. L.; Ryan, A. J.; Gough, T.; Vafabakhsh, R.; Golestanian, R. Self-Motile Colloidal Particles: From Directed Propulsion to Random Walk Phys. Rev. Lett. 2007, 99, 048102
14. Baraban, L.; Makarov, D.; Streubel, R.; Moench, I.; Grimm, D.; Sanchez, S.; Schmidt, O. G. Catalytic Janus Motors on Microfluidic Chip: Deterministic Motion for Targeted Cargo Delivery ACS Nano 2012, 6, 3383-3389
15. Gao, W.; D'Agostino, M.; Garcia-Gradilla, V.; Orozco, J.; Wang, J. Multi-Fuel Driven Janus Micromotors Small 2013, 9, 467-471
16. Mei, Y.; Huang, G.; Solovev, A. A.; Ureña, E. B.; Mönch, I.; Ding, F.; Reindl, T.; Fu, R. K. Y.; Chu, P. K.; Schmidt, O. G. Versatile Approach for Integrative and Functionalized Tubes by Strain Engineering of Nanomembranes on Polymers Adv. Mater. 2008, 20, 4085-4090
17. Manesh, K. M.; Cardona, M.; Yuan, R.; Clark, M.; Kagan, D.; Balasubramanian, S.; Wang, J. Template-Assisted Fabrication of Salt-Independent Catalytic Tubular Microengines ACS Nano 2010, 4, 1799-1804
18. Solovev, A. A.; Mei, Y. F.; Urena, E. B.; Huang, G. S.; Schmidt, O. G. Catalytic Microtubular Jet Engines Self-Propelled by Accumulated Gas Bubbles Small 2009, 5, 1688-1692
19. Gao, W.; Uygun, A.; Wang, J. Hydrogen-Bubble-Propelled Zinc-Based Microrockets in Strongly Acidic Media J. Am. Chem. Soc. 2012, 134, 897-900
20. Wu, Z. G.; Wu, Y. J.; He, W. P.; Lin, X. K.; Sun, J. M.; He, Q. Self-Propelled Polymer-Based Multilayer Nanorockets for Transportation and Drug Release Angew. Chem., Int. Ed. 2013, 52, 7000-7003
21. Wu, Y.; Wu, Z.; Lin, X.; He, Q.; Li, J. Autonomous Movement of Controllable Assembled Janus Capsule Motors ACS Nano 2012, 6, 10910-10916
22. Kagan, D.; Laocharoensuk, R.; Zimmerman, M.; Clawson, C.; Balasubramanian, S.; Kang, D.; Bishop, D.; Sattayasamitsathit, S.; Zhang, L.; Wang, J. Rapid Delivery of Drug Carriers Propelled and Navigated by Catalytic Nanoshuttles Small 2010, 6, 2741-2747
23. Gao, W.; Kagan, D.; Pak, O. S.; Clawson, C.; Campuzano, S.; Chuluun-Erdene, E.; Shipton, E.; Fullerton, E. E.; Zhang, L.; Lauga, E.; Wang, J. Cargo-Towing Fuel-Free Magnetic Nanoswimmers for Targeted Drug Delivery Small 2012, 8, 460-467
24. Balasubramanian, S.; Kagan, D.; Hu, C. M. J.; Campuzano, S.; Lobo-Castanon, M. J.; Lim, N.; Kang, D. Y.; Zimmerman, M.; Zhang, L. F.; Wang, J. Micromachine-Enabled Capture and Isolation of Cancer Cells in Complex Media Angew. Chem., Int. Ed. 2011, 50, 4161-4164
25. Solovev, A. A.; Xi, W.; Gracias, D. H.; Harazim, S. M.; Deneke, C.; Sanchez, S.; Schmidt, O. G. Self-Propelled Nanotools ACS Nano 2012, 6, 1751-1756
26. Gao, W.; Pei, A.; Wang, J. Water-Driven Micromotors ACS Nano 2012, 6, 8432-8438
27. Gao, W.; Feng, X.; Pei, A.; Gu, Y.; Li, J.; Wang, J. Seawater-Driven Magnesium Based Janus Micromotors for Environmental Remediation Nanoscale 2013, 5, 4696-4700
28. Cüneyt Tas, A. Synthesis of Biomimetic Ca-Hydroxyapatite Powders at 37°C in Synthetic Body Fluids Biomaterials 2000, 21, 1429-1438
29. Guan, Y.; Zhang, Y. PNIPAM Microgels for Biomedical Applications: from Fispersed Particles to 3D Assemblies Soft Matter 2011, 7, 6375-6384
30. Trongsatitkul, T.; Budhlall, B. M. Microgels or Microcapsules? Role of Morphology on the Release Kinetics of Thermoresponsive PNIPAm- co -PEGMa Hydrogels Polym. Chem. 2013, 4, 1502-1516
31. 4 Nano/Microlotus Leaves: Fluorescent Properties, Drug delivery, and Biocompatibility CrystEngComm 2014, 16, 1645-1651
32. Lin, Y.-S.; Haynes, C. L. Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity J. Am. Chem. Soc. 2010, 132, 4834-4842
33. Rosenson, R. S.; McCormick, A.; Uretz, E. F. Distribution of Blood Viscosity Values and Biochemical Correlates in Healthy Adults Clin. Chem. 1996, 42, 1189-1195
34. Jang, Y.; Collins, B.; Sankar, J.; Yun, Y. Effect of Biologically Relevant Ions on the Corrosion Products Formed on Alloy AZ31B: An Improved Understanding of Magnesium Corrosion Acta Biomater. 2013, 9, 8761-8770
35. Wang, W.; Chiang, T.-Y.; Velegol, D.; Mallouk, T. E. Understanding the Efficiency of Autonomous Nano- and Microscale Motors J. Am. Chem. Soc. 2013, 135, 10557-10565
36. Guard, L. M.; Hazari, N. Synthesis and Reactivity of Magnesium Complexes Supported by Tris(2-dimethylaminoethyl)amine (Me6tren) Organometallics 2013, 32, 2787-2794
37. Zhang, Y.; Furyk, S.; Bergbreiter, D. E.; Cremer, P. S. Specific Ion Effects on the Water Solubility of Macromolecules: PNIPAM and the Hofmeister Series J. Am. Chem. Soc. 2005, 127, 14505-14510
38. Hoffman, A. S. Applications of Thermally Reversible Polymers and Hydrogels in Therapeutics and Diagnostics J. Controlled Release 1987, 6, 297-305
39. Zhao, G.; Viehrig, M.; Pumera, M. Challenges of The Movement of Catalytic Micromotors in Blood Lab Chip 2013, 13, 1930-1936
40. Sirsi, S. R.; Borden, M. A. Microbubble Compositions, Properties and Biomedical Applications Bubble Sci. Eng. Technol. 2009, 1, 3-17