Effect of linezolid on hematological and oxidative parameters in rats

Journal of Antibiotics

Volumn 67, Issue 6, 2014, Pages 433-437

  Wang, Tianlin ^a   Guo, Daihong ^a   Dong, Xianzhe ^a   Mu, Lihua ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

free radical; hematological effect; linezolid; lipid peroxidation; oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; CATALASE; FREE RADICAL; LINEZOLID; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD CELL; BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ERYTHROCYTE COUNT; HEMATOLOGICAL PARAMETERS; LEUKOCYTE COUNT; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; THROMBOCYTE COUNT;

ACETAMIDES; ANIMALS; ANTIOXIDANTS; BLOOD CELL COUNT; BLOOD CELLS; FREE RADICALS; LIPID PEROXIDATION; MALE; NITRIC OXIDE; OXAZOLIDINONES; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; VITAMIN E;

EID: 84903538851     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2014.21     Document Type: Article

References (25)

1. Yunis, A. A. Chloramphenicol-induced bone marrow suppression. Semin. Hematol. 10, 225-234 (1973
2. Ambekar,C.S.et al. Metabolism of chloramphenicol succinate in human bone marrow. Eur. J. Clin. Pharmacol. 56, 405-409 (2000 (Pubitemid 30666068)
3. Neu, H. C. Safety of cefepime: a new extended-spectrum parenteral cephalosporin. Am. J. Med. 100, 68S-75S (1996
4. Rousan, T. A. et al. Recurrent acute thrombocytopenia in the hospitalized patient: sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia. Am. J. Hematol. 85, 71-74 (2010
5. DeLougher, T. Drug-induced immune hematologic disease. Immunol Allergy. Clin. North. Am. 18, 830-841 (1998
6. Yunis, A. A. Chloramphenicol toxicity: 25 years of research. Am. J. Med. 87, 44N-48N (1989
7. Neftel, K. A., Hauser, S. P. & Muller, M. R. Inhibition of granulopoiesis in vivo and in vitro by b-lactam antibiotics. J. Infect. Dis. 152, 90-98 (1985 (Pubitemid 15038839)
8. Senneville,E. et al. Effectiveness and tolerability of prolonged linezolid treatment for chronic osteomyelitis: a retrospective study. Clin. Ther. 28, 1155-1163 (2006 (Pubitemid 44374746)
9. Falagas, M. E. & Vardakas, K. Z. Benefit-risk assessment of linezolid for serious Grampositive bacterial infections. Drug Saf. 31, 753-768 (2008
10. Minson, Q. & Gentry, C. A. Analysis of linezolid-associated hematologic toxicities in a large veterans affairs medical center. Pharmacotherapy 30, 895-903 (2010
11. Pascoalinho, D., Vilas, M. J., Coelho, L. & Moreira, P. Linezolid-related immunemediated severe thrombocytopenia. Int. J. Antimicrob. 37, 88-89 (2011
12. Tsuji, Y. et al. Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction. J. Infect. Chemother. 17, 70-75 (2011
13. Soundravally, R., Sankar, P., Bobby, Z. & Hoti, S. L. Oxidative stress in severe dengue viral infection: association of thrombocytopenia with lipid peroxidation. Platelets 19, 447-454 (2008
14. Erel, O., Vural, H., Aksoy, N., Aslan, G. & Ulukanligil, M. Oxidative stress of platelets and thrombocytopenia in patients with vivax malaria. Clin. Biochem. 34, 341-344 (2001 (Pubitemid 32607579)
15. Ohkawa, H., Ohishi, N. & Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358 (1979 (Pubitemid 9194347)
16. Slatter, J. G. et al. Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog. Xenobiotica 32, 907-924 (2002 (Pubitemid 35155524)
17. Zurenko, G. E., Ford, C. W., Hutchinson, D. K., Brickner, S. J. & Barbachyn, M. R. Oxazolidinone antibacterial agents: development of the clinical candidates eperezolid and linezolid. Expert Opin. Investig. Drugs 6, 151-158 (1997 (Pubitemid 27101466)
18. Waldrep, T. W. & Skiest, D. J. Linezolid-induced anemia and thrombocytopenia. Pharmacotherapy 22, 109-112 (2002 (Pubitemid 34042396)
19. Bernstein, W. B., Trotta, R. F., Rector, J. T., Tjaden, J. A. & Barile, A. J. Mechanisms for linezolid-induced anemia and thrombocytopenia. Ann. Pharmacother. 37, 517-520 (2003 (Pubitemid 36389660)
20. Traber, M. G. & Stevens, J. F. Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic. Biol. Med. 51, 1000-1013 (2011
21. Yu, B. P. Cellular defenses against damage from reactive oxygen species. Physiol. Rev. 74, 139-162 (1994 (Pubitemid 24045676)
22. Biagini, G., Sala, D. & Zini, I. Diethyldithiocarbamate, a superoxide dismutase inhibitor, counteracts the maturation of ischemic-like lesions caused by endothelin-1 intrastriatal injection. Neurosci. Lett. 190, 212-216 (1995
23. Iuliano, L., Colavita, A. R., Leo, R., Praticò , D. & Violi, F. Oxygen free radicals and platelet activation. Free Radic. Biol. Med. 22, 999-1006 (1997 (Pubitemid 27084137)
24. Beppu, M., Mizukami, A., Nagoya, M. & Kikugawa, K. Binding of anti-band 3 autoantibody to oxidatively damaged erythrocytes. Formation of senescent antigen on erythrocyte surface by an oxidative mechanism. J. Biol. Chem. 265, 3226-3233 (1990
25. Fuchs-Tarlovsky, V., Rivera, M. A., Altamirano, K. A., Lopez-Alvarenga, J. C. & Ceballos-Reyes, G. M. Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients. Support Care. Cancer 21, 1359-1363 (2013).