Identification of marine neuroactive molecules in behaviour-based screens in the larval zebrafish

Marine Drugs

Volumn 12, Issue 6, 2014, Pages 3307-3322

  Long, Si Mei ^a   Liang, Feng Yin ^a   Wu, Qi ^a   Lu, Xi Lin ^a   Yao, Xiao Li ^a   Li, Shi Chang ^a   Li, Jing ^a   Su, Huanxing ^b   Pang, Ji Yan ^a   Pei, Zhong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b University of Macau   (Macao)

Author keywords

Behavior based screen; c fos; PTZ; Zebrafish

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; ISOPRENYL PHENYL ETHER; NATURAL PRODUCT; NEUROACTIVE COMPOUND; PENTETRAZOLE; PROTEIN C FOS; UNCLASSIFIED DRUG; XYLOKETAL DERIVATIVE; ANTICONVULSIVE AGENT; BIOLOGICAL PRODUCT; DIPHENYL ETHER DERIVATIVE; MESSENGER RNA; PYRAN DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; EMBRYO; EPILEPSY; FUNGUS; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HYPERACTIVITY; LARVA; LOCOMOTION; MANGROVE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; ZEBRA FISH; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOTOR ACTIVITY; PROCEDURES; SEA;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; BIOLOGICAL PRODUCTS; DISEASE MODELS, ANIMAL; EPILEPSY; FUNGI; HIGH-THROUGHPUT SCREENING ASSAYS; LARVA; MOTOR ACTIVITY; OCEANS AND SEAS; PENTYLENETETRAZOLE; PHENYL ETHERS; PROTO-ONCOGENE PROTEINS C-FOS; PYRANS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH;

EID: 84903525212     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12063307     Document Type: Article

References (25)

1. Pangalos, M.N.; Schechter, L.E.; Hurko, O. Drug development for CNS disorders: Strategies for balancing risk and reducing attrition. Nat. Rev. Drug Discov. 2007, 6, 521-532. (Pubitemid 47019441)
2. Kokel, D.; Peterson, R.T. Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Brief. Funct. Genomics Proteomics 2008, 7, 483-490.
3. Brockerhoff, S.E.; Hurley, J.B.; Janssen-Bienhold, U.; Neuhauss, S.C.; Driever, W.; Dowling, J.E. A behavioral screen for isolating zebrafish mutants with visual system defects. Proc. Natl. Acad. Sci. USA 1995, 92, 10545-10549.
4. Neuhauss, S.C.; Biehlmaier, O.; Seeliger, M.W.; Das, T.; Kohler, K.; Harris, W.A.; Baier, H. Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J. Neurosci. 1999, 19, 8603-8615. (Pubitemid 30226778)
5. Burgess, H.A.; Granato, M. Sensorimotor gating in larval zebrafish. J. Neurosci. 2007, 27, 4984-4894.
6. Prober, D.A.; Rihel, J.; Onah, A.A.; Sung, R.J.; Schier, A.F. Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. J. Neurosci. 2006, 26, 13400-13410. (Pubitemid 46011651)
7. Zhdanova, I.V.; Wang, S.Y.; Leclair, O.U.; Danilova, N.P. Melatonin promotes sleep-like state in zebrafish. Brain Res. 2001, 903, 263-268. (Pubitemid 32904633)
8. Kokel, D.; Bryan, J.; Laggner, C.; White, R.; Cheung, C.Y.; Mateus, R.; Healey, D.; Kim, S.; Werdich, A.A.; Haggarty, S.J.; et al. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat. Chem. Biol. 2010, 6, 231-237.
9. Rihel, J.; Prober, D.A.; Arvanites, A.; Lam, K.; Zimmerman, S.; Jang, S.; Haggarty, S.J.; Kokel, D.; Rubin, L.L.; Peterson, R.T.; et al. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 2010, 327, 348-351.
10. Li, S.; Shen, C.; Guo, W.; Zhang, X.; Liu, S.; Liang, F.; Xu, Z.; Pei, Z.; Song, H.; Qiu, L.; Lin, Y.; Pang, J. Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models. Mar. Drugs 2013, 11, 5159-5189.
11. Liu, R.; Zhou, Z.Y.; Jiang, M.Y.; Wang, F.; Liu, J.K. A new isoprenyl phenyl ether riboside from the culture of basidiomycete Laccaria amethystea. J. Asian Nat. Prod. Res. 2010, 12, 723-726.
12. Li, J.; Zhang, D.; Zhu, X.; He, Z.; Liu, S.; Li, M.; Pang, J.; Lin, Y. Studies on synthesis and structure-activity relationship (SAR) of derivatives of a new natural product from marine fungi as inhibitors of influenza virus neuraminidase. Mar. Drugs 2011, 9, 1887-1901.
13. Pettigrew, J.D.; Wilson, P.D. Synthesis of xyloketal A, B, C, D, and G analogues. J. Organ. Chem. 2006, 71, 1620-1625.
14. Xu, Z.; Li, Y.; Xiang, Q.; Pei, Z.; Liu, X.; Lu, B.; Chen, L.; Wang, G.; Pang, J.; Lin, Y. Design and synthesis of novel xyloketal derivatives and their vasorelaxing activities in rat thoracic aorta and angiogenic activities in zebrafish angiogenesis screen. J. Med. Chem. 2010, 53, 4642-4653.
15. Guo, S. Linking genes to brain, behavior and neurological diseases: What can we learn from zebrafish? Genes Brain Behav. 2004, 3, 63-74. (Pubitemid 38405251)
16. Epilepsy Fact Sheet, World Health Organization. October 2012. Available online: http://www.who.int/mediacentre/factsheets/fs999/en/ (accessed on 10 May 2014).
17. Mussulini, B.H.; Leite, C.E.; Zenki, K.C.; Moro, L.; Baggio, S.; Rico, E.P.; Rosemberg, D.B.; Dias, R.D.; Souza, T.M.; Calcagnotto, M.E.; et al. Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization. PLoS One 2013, 8, e54515.
18. Scallet, A.C.; Kowalke, P.K.; Rountree, R.L.; Thorn, B.T.; Binienda, Z.K. Electroencephalographic, behavioral, and c-fos responses to acute domoic acidexposure. Neurotoxicol. Teratol. 2004, 26,331-342. (Pubitemid 38327116)
19. Fleming, A.; Diekmann, H.; Goldsmith, P. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One 2013, 8, e77548.
20. Ghasemi, M.; Shafaroodi, H.; Nazarbeiki, S.; Meskar, H.; Heydarpour, P.; Ghasemi, A.; Talab, S.S.; Ziai, P.; Bahremand, A.; Dehpour, A.R. Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice. Epilepsy Behav. 2010, 18, 171-178.
21. 2+ antagonist. Epilepsia 1987, 28, 409-414.
22. Moron, M.A.; Stevens, C.W.; Yaksh, T.L. The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat. J. Pharmacol. Exp. Ther. 1990, 252, 1150-1155. (Pubitemid 20127422)
23. Wu, X.Y.; Liu, X.H.; Lin, Y.C.; Luo, J.H.; She, Z.G.; Jin, L.H.; Chan, W.L.; Antus, S.; Kurtan, T.; Elsässer, B.; et al. Xyloketal F: A strong L-calcium channel blocker from the mangrove fungus xylaria sp. (#2508) from the South China Sea Coast. Eur. J. Org. Chem. 2005, 2005, 4061-4064.
24. Westerfield, M. The Zebrafish Book: A Guide for Laboratory Use of Zebrafish (Danio rerio); University of Oregon Press: Eugene, OR, USA, 1995.
25. Livak, K.J.; Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25, 402-408. (Pubitemid 34164012)