Have we changed the natural history of pediatric crohn's disease with biologics?

Digestive Diseases

Volumn 32, Issue 4, 2014, Pages 360-363

  Dubinsky, Marla ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Biologics; Crohn's disease; Pediatrics; Surgery

Indexed keywords

IMMUNOMODULATING AGENT; MERCAPTOPURINE; TUMOR NECROSIS FACTOR INHIBITOR; BIOLOGICAL PRODUCT;

CROHN DISEASE; DRUG EFFICACY; DRUG WITHDRAWAL; FOLLOW UP; HISTORY; HUMAN; INTESTINE SURGERY; MAINTENANCE THERAPY; META ANALYSIS (TOPIC); PREDICTION; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW (TOPIC); TREATMENT OUTCOME; ARTICLE; BIOLOGICAL THERAPY; CHILDHOOD DISEASE; COHORT ANALYSIS; FAMILY HISTORY; IMMUNOMODULATION; INTERVENTION STUDY; OBSERVATIONAL STUDY; PATIENT MONITORING; PEDIATRIC SURGERY; PREDICTOR VARIABLE; TREATMENT WITHDRAWAL; DISEASE COURSE; PATHOLOGY; PROGNOSIS;

BIOLOGICAL PRODUCTS; CROHN DISEASE; DISEASE PROGRESSION; HUMANS; PROGNOSIS;

EID: 84903482531     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000358137     Document Type: Review

References (13)

1. Frolkis AD, Dykeman J, Negrón ME, deBruyn J, Jette N, Fiest KM, Frolkis T, Barkema HW, Rioux KP, Panaccione R, Ghosh S, Wiebe S, Kaplan GG: Risk of surgery for the inflammatory bowel diseases has decreased over time: a systematic review and meta-Analysis of population-based studies. Gastroenterology 2013; 145: 996-1006.
2. Cosnes J, Cattan S, Blain A, Beaugerie L, Carbonnel F, Parc R, Gendre JP: Long-term evolution of disease behavior of Crohn's disease. Inflamm Bowel Dis 2002; 8: 244-250.
3. Binder V, Hendriksen C, Kreiner S: Prognosis in Crohn's disease-based on results from a regional patient group from the county of Copenhagen. Gut 1985; 26: 146-150.
4. Vernier-Massouille G, Balde M, Salleron J, Turck D, Dupas JL, Mouterde O, Merle V, Salomez JL, Branche J, Marti R, Lerebours E, Cortot A, Gower-Rousseau C, Colombel JF: Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology 2008; 135: 1106-1113.
5. Boualit M, Salleron J, Turck D, Fumery M, Savoye G, Dupas JL, Lerebours E, Duhamel A, Merle V, Cortot A, Colombel JF, Peyrin-Biroulet L, Gower-Rousseau C; EPIMAD Group: Long-term outcome after first intestinal resection in pediatric-onset Crohn's disease: a population-based study. Inflamm Bowel Dis 2013; 19: 7-14.
6. Aloi M, Viola F, D'Arcangelo G, Di Nardo G, Civitelli F, Casciani E, Oliva S, Nuti F, Dilillo A, Cucchiara S: Disease course and efficacy of medical therapy in stricturing paediatric Crohn's disease. Dig Liver Dis 2013; 45: 464-468.
7. Lau CC, Dubinsky MC, Melmed GY, Vasiliauskas EA, McGovern DP, Berel D, Murrell ZR, Ippoliti A, Shih DQ, Kaur M, Targan SR, Fleshner P: Influence of biologic agents on short-term postoperative complications in patients with Crohn's disease: a prospective, single-surgeon cohort study. Gastroenterology 2013; 144(suppl 1):407.
8. Beaugerie L, Seksik P, Nion-Larmurier I, Gendre JP, Cosnes J: Predictors of Crohn's disease. Gastroenterology 2006; 130: 650-656.
9. Desir B, Amre DK, Lu SE, Ohman-Strickland P, Dubinsky M, Fisher R, Seidman EG: Utility of serum antibodies in determining clinical course in pediatric Crohn's disease. Clin Gastroenterol Hepatol 2004; 2: 139-146.
10. Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros JA, Silber G, Wahbeh G, Katzir L, Vasiliauskas EA, Bahar RJ, Otley A, Mack DR, Evans J, Rosh JR, Hemker MO, Leleiko NS, Crandall WV, Langton C, Landers C, Taylor KD, Targan SR, Rotter JI, Markowitz JF, Hyams JS; Western Regional Pediatric IBD Research Alliance; Pediatric IBD Collaborative Research Group; Wisconsin Pediatric IBD Alliance: Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clin Gastroenterol Hepatol 2008; 6: 1105-1111.
11. Amre DK, Lu SE, Costea F, Seidman EG: Utility of serological markers in predicting the early occurrence of complications and surgery in pediatric Crohn's disease patients. Am J Gastroenterol 2006; 101: 645-652.
12. Annese V, Lombardi G, Perri F, D'Inca R, Ardizzone S, Riegler G, Giaccari S, Vecchi M, Castiglione F, Gionchetti P, Cocchiara E, Vigneri S, Latiano A, Palmieri O, Andriulli A: Variants of CARD15 are associated with an aggressive clinical course of Crohn's disease-An IG-IBD study. Am J Gastroenterol 2005; 100: 84-92.
13. Siegel CA, Siegel LS, Hyams JS, Kugathasan S, Markowitz J, Rosh JR, Leleiko N, Mack DR, Crandall W, Evans J, Keljo DJ, Otley AR, Oliva-Hemker M, Farrior S, Langton CR, Wrobel IT, Wahbeh G, Quiros JA, Silber G, Bahar RJ, Sands BE, Dubinsky MC: Real-time tool to display the predicted disease course and treatment response for children with Crohn's disease. Inflamm Bowel Dis 2011; 17: 30-38.