Trends in childhood drug-resistant tuberculosis in South Africa: A window into the wider epidemic?

International Journal of Tuberculosis and Lung Disease

Volumn 18, Issue 7, 2014, Pages

  Schaaf, H Simon ^a,b   Hesseling, A C ^a   Rautenbach, C ^b   Seddon, J A ^a,c  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Children; Multidrug resistant; Paediatric; Surveillance; TB

Indexed keywords

AMIKACIN; ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; KATG PROTEIN; OFLOXACIN; STREPTOMYCIN; BACTERIAL PROTEIN; INHA PROTEIN, MYCOBACTERIUM; OXIDOREDUCTASE; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL TRANSMISSION; BACTERIUM ISOLATE; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; DISEASE SURVEILLANCE; DRUG RESISTANT TUBERCULOSIS; EPIDEMIC; FEMALE; GENE MUTATION; HEALTH SURVEY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RATE; INHA GENE; KATG GENE; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANT TUBERCULOSIS; PRIORITY JOURNAL; PROMOTER REGION; SOUTH AFRICA; TREND STUDY; AGE; DRUG EFFECTS; HIV INFECTIONS; INFANT; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; PRESCHOOL CHILD; TUBERCULOSIS, MULTIDRUG-RESISTANT;

AGE FACTORS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ETHIONAMIDE; FEMALE; HIV INFECTIONS; HUMANS; INFANT; MALE; MYCOBACTERIUM TUBERCULOSIS; OFLOXACIN; OXIDOREDUCTASES; PROMOTER REGIONS, GENETIC; SOUTH AFRICA; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84903466202     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.13.0069     Document Type: Article

References (10)

1. Marais B J, Gie R P, Schaaf H S, et al. The clinical epidemiology of childhood pulmonary tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis 2004; 8: 278-285. (Pubitemid 38624864)
2. Zignol M, Sismanidis C, Falzon D, Glaziou P, Dara M, Floyd K. Multidrug-resistant tuberculosis in children: evidence from global surveillance. Eur Respir J 2013; 42: 701-707.
3. Schaaf H S, Marais B J, Hesseling A C, Brittle W, Donald P R. Surveillance of anti-tuberculosis drug resistance among children from the Western Cape Province of South Africa - an upward trend. Am J Public Health 2009; 99: 1486-1490.
4. Shah N S, Yuen CM, Heo M, Tolman AW, BecerraMC. Yield of contact investigations in households of patients with drug-resistant tuberculosis: systematic review and meta-analysis. Clin Infect Dis 2014; 58: 381-391.
5. Schaaf H S, Marais B J, Hesseling A C, Gie R P, Beyers N, Donald P R. Childhood drug-resistant tuberculosis in the Western Cape Province of South Africa. Acta Paediatr 2006; 95: 523-528. (Pubitemid 43791572)
6. Seddon J A, Hesseling A C, Marais B J, Jordaan A, Victor T, Schaaf H S. The evolving epidemic of drug-resistant tuberculosis among children in Cape Town, South Africa. Int J Tuberc Lung Dis 2012; 16: 928-933.
7. Barnard M, Albert H, Coetzee G, O'Brien R, Bosman M E. Rapid molecular screening for multidrug-resistant tuberculosis in a high-volume public health laboratory in South Africa. Am J Respir Crit Care Med 2008; 177: 787-792. (Pubitemid 351490566)
8. Van Schalkwyk M, Andersson M I, Zeier M D, La Grange M, Taljaard J J, Theron G B. The impact of revised PMTCT guidelines: a view from a public sector ARV clinic in Cape Town, South Africa. J Acquir Immune Defic Syndr 2013; 63: 234-238.
9. Schaaf H S, Victor T C, Venter A, et al. Ethionamide cross- and co-resistance in children with isoniazid-resistant tuberculosis. Int J Tuberc Lung Dis 2009; 13: 1355-1359.
10. Thee S, Seifart H I, Rosenkranz B, et al. Pharmacokinetics of ethionamide in children. Antimicrob Agents Chemother 2011; 55: 4594-4600.