Anti-HIV drug particles may overcome lymphatic drug insufficiency and associated HIV persistence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 25, 2014, Pages

  Freeling, Jennifer P ^a   Ho, Rodney J Y ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GADOLINIUM; HEMATOLOGIC AGENT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INDINAVIR; LIPID; LYMPHATIC DRUG; NANOPARTICLE; UNCLASSIFIED DRUG;

CD4+ T LYMPHOCYTE; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG RETENTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; LYMPHATIC DRAINAGE; LYMPHATIC SYSTEM; PERSISTENT VIRUS INFECTION; PH; PRIORITY JOURNAL; RNA VIRUS;

ANTI-HIV AGENTS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOID TISSUE; MALE; VIRUS REPLICATION;

EID: 84903458727     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406554111     Document Type: Letter

References (5)

1. Fletcher CV, et al. (2014) Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci USA 111(6):2307-2312.
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3. Heath TJ, Kerlin RL, Spalding HJ (1986) Afferent pathways of lymph flow within the popliteal node in sheep. J Anat 149:65-75. (Pubitemid 17006059)
4. Kinman L, et al. (2006) Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaques. J Acquir Immune Defic Syndr 42(2):155-161. (Pubitemid 43884709)
5. Bui T, et al. (2010) Novel Gd nanoparticles enhance vascular contrast for high-resolution magnetic resonance imaging. PLoS ONE 5(9):e13082.