False-positive Xpert® MTB/RIF assays in previously treated patients: Need for caution in interpreting results

International Journal of Tuberculosis and Lung Disease

Volumn 18, Issue 7, 2014, Pages

  Boyles, Tom H ^a   Hughes, J ^b   Cox, V ^b   Burton, R ^c   Meintjes, G ^d   Mendelson, M ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b MÉDECINS SANS FRONTIÈRES   (Switzerland)

^c Khayelitsha Hospital   (South Africa)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Diagnostic test; Specificity; Tuberculosis

Indexed keywords

AMOXICILLIN; ETHAMBUTOL; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CULTURE; CASE REPORT; COUGHING; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DRUG TREATMENT FAILURE; DYSPNEA; FALSE POSITIVE RESULT; FEMALE; HUMAN; LUNG FIBROSIS; LUNG INFILTRATE; LUNG NODULE; LUNG TUBERCULOSIS; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SENSITIVITY AND SPECIFICITY; SPUTUM CULTURE; THORAX RADIOGRAPHY; TUBERCULOSIS RAPID TEST; ISOLATION AND PURIFICATION; LABORATORY DIAGNOSIS; LUNG; MICROBIOLOGY; NUCLEIC ACID AMPLIFICATION; PROCEDURES; RESPIRATORY TRACT INFECTIONS; SPUTUM; TUBERCULOSIS;

FALSE POSITIVE REACTIONS; FEMALE; HUMANS; LUNG; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; RESPIRATORY TRACT INFECTIONS; SENSITIVITY AND SPECIFICITY; SPUTUM; TUBERCULOSIS;

EID: 84903453444     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.13.0853     Document Type: Article

References (5)

1. World Health Organization. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF System. WHO/HTM/TB/2011.4. Geneva, Switzerland: WHO, 2011. http://whqlibdoc.who.int/publications/2011/9789241501545-eng.pdf. Accessed April 2014.
2. Steingart K, Sohn H, Schiller I, et al. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev 2013; 1: CD009593.
3. Friedrich S O, Rachow A, Saathoff E, et al. Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment. Lancet Respir Med 2013; 1: 462-470.
4. Boehme C C, Nabeta P, Hillemann D, et al. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 2010; 363: 1005-1015.
5. Boehme C C, Nicol M P, Nabeta P, et al. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet 2011; 377: 1495-1505.