Recovery of consciousness is mediated by a network of discrete metastable activity states

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 25, 2014, Pages 9283-9288

  Hudson, Andrew E ^a   Calderon, Diany Paola ^b   Pfaff, Donald W ^b   Proekt, Alex ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Anesthesia; Emergence; Spectral analysis; State transitions

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; COMA; CONSCIOUSNESS; CONTINUOUS PROCESS; ELECTROENCEPHALOGRAM; METASTABLE ACTIVITY STATE; MOLECULAR DYNAMICS; NERVOUS SYSTEM PARAMETERS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; WAKEFULNESS;

ANESTHESIA; EMERGENCE; SPECTRAL ANALYSIS; STATE TRANSITIONS;

ANIMALS; COMA; CONSCIOUSNESS; NERVE NET; RATS;

EID: 84903438378     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408296111     Document Type: Article

References (31)

1. Lammi MH, Smith VH, Tate RL, Taylor CM (2005) The minimally conscious state and recovery potential: A follow-up study 2 to 5 years after traumatic brain injury. Arch Phys Med Rehabil 86(4):746-754. (Pubitemid 40487842)
2. Brown EN, Lydic R, Schiff ND (2010) General anesthesia, sleep, and coma. N Engl J Med 363(27):2638-2650.
3. Tuckwell HC (1989) Stochastic Processes in the Neurosciences (Society for Industrial and Applied Mathematics, Philadelphia).
4. Levinthal C (1968) Are there pathways for protein folding? J Chim Phys 65(1):44-45.
5. Schiff ND (2008) Central thalamic contributions to arousal regulation and neurological disorders of consciousness. Ann N Y Acad Sci 1129(1):105-118.
6. Alkire MT, Hudetz AG, Tononi G (2008) Consciousness and anesthesia. Science 322(5903):876-880.
7. Percival DB, Walden AT (1993) Spectral Analysis for Physical Applications (Cambridge Univ Press, Cambridge, UK).
8. Destexhe A, Contreras D, Steriade M (1999) Spatiotemporal analysis of local field potentials and unit discharges in cat cerebral cortex during natural wake and sleep states. J Neurosci 19(11):4595-4608. (Pubitemid 29241107)
9. Gervasoni D, et al. (2004) Global forebrain dynamics predict rat behavioral states and their transitions. J Neurosci 24(49):11137-11147. (Pubitemid 40012973)
10. Stratmann G, et al. (2009) Increasing the duration of isoflurane anesthesia decreases the minimum alveolar anesthetic concentration in 7-day-old but not in 60-day-old rats. Anesth Analg 109(3):801-806.
11. Swank RL, Watson CW (1949) Effects of barbiturates and ether on spontaneous electrical activity of dog brain. J Neurophysiol 12(2):137-160.
12. Stecker MM, et al. (2001) Deep hypothermic circulatory arrest: I. Effects of cooling on electroencephalogram and evoked potentials. Ann Thorac Surg 71(1):14-21. (Pubitemid 32102627)
13. Ohtahara S, Ohtsuka Y, Yamatogi Y, Oka E (1987) The early-infantile epileptic encephalopathy with suppression-burst: Developmental aspects. Brain Dev 9(4):371-376. (Pubitemid 18032024)
14. Thömke F, Brand A, Weilemann SL (2002) The temporal dynamics of postanoxic burst-suppression EEG. J Clin Neurophysiol 19(1):24-31. (Pubitemid 34242490)
15. Steriade M, Nuñez A, Amzica F (1993) A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: Depolarizing and hyperpolarizing components. J Neurosci 13(8):3252-3265. (Pubitemid 23241166)
16. Nunez PL (2006) Electric Fields of the Brain: The Neurophysics of EEG (Oxford Univ Press, New York).
17. Steriade M, Gloor P, Llinás RR, Lopes de Silva FH, Mesulam MM (1990) Report of IFCN Committee on Basic Mechanisms. Basic mechanisms of cerebral rhythmic activities. Electroencephalogr Clin Neurophysiol 76(6):481-508.
18. Franks NP (2008) General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 9(5):370-386.
19. Doyle PG, Snell JL (2000) Random walks and electric networks. Carus Mathematical Monographs 22:1-120.
20. Jones EG (1998) Viewpoint: The core and matrix of thalamic organization. Neuroscience 85(2):331-345.
21. Alkire MT, McReynolds JR, Hahn EL, Trivedi AN (2007) Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat. Anesthesiology 107(2):264-272. (Pubitemid 47196490)
22. Lioudyno MI, et al. (2013) Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci 33(41):16310-16322.
23. Långsjö JW, et al. (2012) Returning from oblivion: Imaging the neural core of consciousness. J Neurosci 32(14):4935-4943.
24. Schiff ND, et al. (2007) Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 448(7153):600-603. (Pubitemid 47206940)
25. Gibbs FA, Gibbs EL, Lennox WG (1937) Effect on the electro-encephalogram of certain drugs which influence nervous activity. Arch Intern Med 60(1):154-166.
26. Whitlock E, et al. (2011) Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial. Anesthesiology 115(6):1209-1218.
27. Kelz MB, et al. (2008) An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci USA 105(4):1309-1314. (Pubitemid 351397049)
28. Friedman EB, et al. (2010) A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: Evidence for neural inertia. PLoS One 5(7):e11903.
29. Victor JD, Drover JD, Conte MM, Schiff ND (2011) Mean-field modeling of thalamocortical dynamics and a model-driven approach to EEG analysis. Proc Natl Acad Sci USA 108(Suppl 3):15631-15638.
30. Strogatz SH (1994) Nonlinear Dynamics and Chaos (Perseus, Reading, MA).
31. Clement EA, et al. (2008) Cyclic and sleep-like spontaneous alternations of brain state under urethane anaesthesia. PLoS One 3(4):e2004.