Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) fibrous mats

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 102, Issue 3, 2014, Pages 533-542

  Fu, Shao Zhi ^a   Meng, Xiao Hang ^a   Fan, Juan ^a   Yang, Ling Lin ^a   Wen, Qing Lian ^a   Ye, Su Juan ^a   Lin, Sheng ^a   Wang, Bi Qiong ^a   Chen, Lan Lan ^a   Wu, Jing Bo ^a   Chen, Yue ^a   Fan, Jun Ming ^a   Li, Zhi ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

curcumin; dermal defect; fibrous mats; PCL PEG PCL; wound healing

Indexed keywords

COMPOSITE SCAFFOLDS; CURCUMIN; CYTOTOXICITY ASSAYS; DERMAL WOUND HEALING; FIBROUS MATS; LOW CYTOTOXICITIES; PCL-PEG-PCL; WOUND HEALING;

DEFECTS; POLYETHYLENE OXIDES; REPAIR; SCAFFOLDS;

POLYETHYLENE GLYCOLS;

COPOLYMER; CURCUMIN; MACROGOL; POLYCAPROLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG RELEASE; ELECTROSPINNING; FEMALE; HISTOPATHOLOGY; MOUSE; NONHUMAN; POLYMERIZATION; RAT; SKIN FIBROBLAST; SKIN INJURY; TISSUE ENGINEERING; WOUND CLOSURE; WOUND DRESSING; WOUND HEALING;

CURCUMIN; DERMAL DEFECT; FIBROUS MATS; PCL-PEG-PCL; WOUND HEALING;

ANIMALS; ANTIOXIDANTS; BIOCOMPATIBLE MATERIALS; CELL SURVIVAL; CURCUMIN; DRUG DELIVERY SYSTEMS; FEMALE; FIBROBLASTS; MICE; MICROSCOPY, ELECTRON, SCANNING; POLYESTERS; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SKIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; TISSUE ENGINEERING; TISSUE SCAFFOLDS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84903370884     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.33032     Document Type: Article

References (37)

1. Muhlstadt M, Thome C, Kunte C,. Rapid wound healing of scalp wounds devoid of periosteum with milling of the outer table and split-thickness skin grafting. Br J Dermatol 2012; 167: 343-347.
2. Bermudez DM, Herdrich BJ, Xu J, Lind R, Beason DP, Mitchell ME, Soslowsky LJ, Liechty KW,. Impaired biomechanical properties of diabetic skin: implications in pathogenesis of diabetic wound complications. Am J Pathol 2011; 178: 2215-2223.
3. Kumar MS, Kirubanandan S, Sripriya R, Sehgal PK,. Triphala promotes healing of infected full-thickness dermal wound. J Surg Res 2008; 144: 94-101.
4. Robson MC,. Wound infection: A failure of wound healing caused by an imbalance of bacteria. Surg Clin N Am 1997; 77: 637-650.
5. Gopinath D, Ahmed MR, Gomathi K, Chitra K, Sehgal PK, Jayakumar R,. Derma wound healing processes with curcumin incorporated collagen films. Biomaterials 2004; 25: 1911-1917.
6. Hunt TK, Hopf H, Hussain Z,. Physiology of wound healing. Adv Skin Wound Care 2000; 13: 6-11.
7. Sidhu GS, Mani H, Gaddipatti JP, Singh AK, Seth P, Banaudha KK, Patnaik GK, Maheshwari RK,. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 1999; 7: 362-374.
8. Cronin H, Goldstein G,. Biologic skin substitutes and their applications in dermatology. Dermatol Surg 2012: 1-5.
9. Schneider A, Wang XY, Kaplan DL, Garlick JA, Egles C,. Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater 2009; 5: 2570-2578.
10. Huang MH, Yang MC,. Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Inter J Pharmaceut 2008; 346: 38-46.
11. Lakshman LR, Shalumon KT, Nair SV, Jayakumar R, Nair SV,. Preparation of silver nanoparticles incorporated electrospun polyurethane nano-fibrous mat for wound dressing. J Macromol Sci A 2010; 47: 1012-1018.
12. Boucard N, Viton C, Agay D, Mari E, Roger T, Chancerelle Y, Domard A,. The use of physical hydrogels of chitosan for skin regeneration following third-degree burns. Biomaterials 2007; 28: 3478-3488.
13. Jones I, Currie L, Martin R,. A guide to biological skin substitutes. Br J Plast Surg 2002; 55: 185-193.
14. Gentzkow GD, Iwasi SD, Hershon KS,. Use of dermagraft, a cultured human dermis to treat diabetic foot ulcer. Diabetes Care 1996; 19: 350-354.
15. Eaglstein WH, Falanga V,. Tissue engineering and development of Apligraft® a human skin equivalent. Clin Ther 1997; 19: 894-905.
16. Babaeijandaghi F, Shabani I, Seyedjafari E, Naraghi ZS, Vasei M, Haddadi-Asl V, Hesari KK, Soleimani M,. Accelerated epidermal regeneration and improved dermal reconstruction achieved by polyethersulfone nanofibers. Tissue Eng Part A 2010; 16: 3527-3536.
17. Vargas EAT, Baracho NCV, Brito J, Queiroz AAA,. Hyperbranched polyglycerol electrospun nanofibers for wound dressing applications. Acta Biomater 2010; 6: 1069-1078.
18. Merrell JG, McLaughlin SW, Lu T, Laurencin CT, Chen AF, Nair LS,. Curcumin loaded poly(ε-caprolactone) nanofibers: Diabetic wound dressing with antioxidant and anti-inflammatory properties. Clin Exp Pharmacol Physio 2009; 36: 1149-1156.
19. Suganya S, Senthil Ram T, Lakshmi BS, Giridev VR,. Herbal drug incorporated antibacterial nanofibrous mat fabricated by electrospinning: An excellent matrix for wound dressings. J Appl Polym Sci 2011; 121: 2893-2899.
20. Suwantong O, Opanasopit P, Ruktanonchai U, Supaphol P,. Electrospun cellulose acetate fiber mats containing curcumin and release characteristic of the herbal substance. Polymer 2007; 48: 7546-7557.
21. Guo G, Fu SZ, Zhou LX, Liang H, Fan M, Luo F, Qian ZY, Wei YQ,. Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)- poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma cells. Nanoscale 2011; 3: 3825-3832.
22. Fu SZ, Wang XH, Guo G, Shi S, Liang H, Luo F, Wei YQ, Qian ZY,. Preparation and characterization of nano-hydroxyapatite/Poly(ε- caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone) composite fibers for tissue engineering. J Phys Chem C 2010; 114: 18372-18378.
23. Murakami K, Aoki H, Nakamura S, Nakamura S, Takikawa M, Hanzawa M, Kishimoto S, Hattori H, Tanaka Y, Kiyosawa T, Sato Y, Ishihara M,. Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings. Biomaterials 2010; 31: 83-90.
24. Chen KY, Liao WJ, Kuo SM, Tsai FJ, Chen YS, Huang CY, Yao CH,. Asymmetric chitosan membrane containing collagen I nanospheres for skin tissue engineering. Biomacromolecules 2009; 10: 1642-1649.
25. Fu SZ, Wang XH, Guo G, Shi S, Fan M, Liang H, Luo F, Qian ZY,. Preparation and properties of nano-hydroxyapatite/PCL-PEG-PCL composite membranes for tissue engineering applications. J Biomed Mater Res Part B 2011; 97: 74-83.
26. Zhou SB, Zheng XT, Yu XJ, Wang JX, Weng J, Li XH, Feng B, Yin M,. Hydrogen bonding interaction of Poly(d, l -Lactide)/hydroxyapatite nanocomposites. Chem Mater 2007; 19: 247-253.
27. Supaphol P, Suwantong O, Sansanoh P, Sowmya S, Jayakumar R, Nair SV,. Electrospinning of biocompatible polymers and their potentials in biomedical applications. Adv Polym Sci 2012; 246: 213-240.
28. Prabaharan M, Jayakumar R, Nair SV,. Electrospun nanofibrous scaffolds-current status and prospectus in drug delivery ", Adv Polym Sci 2012; 246: 241-262.
29. Panchatcharam M, Miriyala S, Gayathri VS, Suguna L,. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem 2006; 290: 87-96.
30. Kowluru RA, Kanwar M,. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metab 2007; 4: 8-15.
31. Notoya M, Nishimura H, Woo J-T, Nagai K, Ishihara Y, Hagiwara H,. Curcumin inhibits the proliferation and mineralization of cultured osteoblasts. Eur J Pharmacol 2008; 534: 55-62.
32. Scharstuhl A, Mutsaers HA, Pennings SW, Szarek WA, Russel FG, Wagener FA,. Curcumin induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: Implications for scar formation. J Cell Mol Med 2009; 13: 12-725.
33. Bhagavathula N, Warner RL, Dasilva M, McClintock SD, Barron A, Adlam MN, Johnson KJ, Varani J,. Acombination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin. Wound Repair Regen 2009; 17: 360-366.
34. Li X, Chen S, Zhang B, Li M, Diao K, Zhang Z, Li J, Xu Y, Wang X, Chen H,. In situ injectable nano-composite hydrogel composed of curcumin, N,O-carboxymethyl chitosan and oxidized alginate for wound healing application. Int J Pharmceut 2012; 437: 110-119.
35. Liang G, Li X, Chen L, Yang S, Wu X, Studer E, Gurley E, Hylemon PB, Ye F, Li Y, Zhou H,. Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin. Bioorg Med Chem Lett 2008; 18: 1525-1529.
36. Yuvarani I, Kumar SS, Venkatesan J, Kim SK, Sudha PN,. Preparation and characterization of curcumin coated chitosan-alginate blend for wound dressing application. J Biomater Tissue Eng 2012; 2: 54-60.
37. Li X, Nan K, Li L, Zhang Z, Chen H,. In vivo evaluation of curcumin nanoformulation loaded methoxy poly(ethylene glycol)-graft-chitosan composite film for wound healing application. Carbohyd Polym 2012; 88: 84-90.