Phosphate additives in food - A health risk;Gesundheitsrisiko durch Phosphatzusätze in Nahrungsmitteln

Deutsches Arzteblatt International

Volumn 109, Issue 4, 2012, Pages 49-55

  Ritz, Eberhard ^a   Hahn, Kai ^b   Ketteler, Markus ^c   Kuhlmann, Martin K ^d   Mann, Johannes ^e  

^a Nierenzentrum Heidelberg   (Germany)

^b Nephrologische Praxis Dialyse   (Germany)

^c KLINIKUM COBURG   (Germany)

^d VIVANTES KLINIKUM IM FRIEDRICHSHAIN   (Germany)

^e Klinikum Schwabing   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ESTER; FOOD ADDITIVE; PHOSPHATE;

BLOOD VESSEL CALCIFICATION; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CHRONIC KIDNEY DISEASE; DATA BASE; HEALTH HAZARD; HUMAN; HYPERPHOSPHATEMIA; KWASHIORKOR; MEDLINE; MORTALITY; NUTRITIONAL PARAMETERS; PHOSPHATE BLOOD LEVEL; POPULATION; PREVALENCE; REVIEW; SOCIAL STATUS;

EID: 84903362540     PISSN: 18660452     EISSN: None     Source Type: Journal    
DOI: 10.3238/arztebl.2012.0049     Document Type: Review

References (35)

1. Sullivan C, et al.: Effect of food additives on hyperphosphatemia among patients with end-stage renal disease: a randomized controlled trial. JAMA 2009; 301: 629-35.
2. Block GA, et al.: Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. JASN 2004; 15: 2208-18.
3. Kestenbaum B, et al.: Serum phosphate levels and mortality risk among people with chronic kidney disease. JASN 2005; 16: 520-8.
4. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl 2009: S1-130.
5. Noori N, et al.: Association of dietary phosphorus intake and phosphorus to protein ratio with mortality in hemodialysis patients. CJASN 2010; 5: 683-92.
6. Foley RN, et al.: Serum phosphorus levels associate with coronary atherosclerosis in young adults. JASN 2009; 20: 397-404.
7. Dhingra R, et al.: Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 2007; 167: 879-85.
8. Tonelli M, et al.: Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005; 112: 2627-33.
9. Gutierrez OM, et al.: Low socioeconomic status associates with higher serum phosphate irrespective of race. JASN 2010; 21: 1953-60.
10. Berndt T, Kumar R: Novel mechanisms in the regulation of phosphorus homeostasis. Physiology (Bethesda) 2009; 24: 17-25.
11. Liu S, Quarles LD: How fibroblast growth factor 23 works. JASN 2007; 18: 1637-47.
12. Shimada T, et al.: Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 2004; 113: 561-8.
13. Wetmore JB, Quarles LD: Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift? Nat Clin Pract Nephrol 2009; 5: 24-33.
14. Kuro-o M, et al.: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-51.
15. Kuro-o M: A potential link between phosphate and aging-lessons from Klotho-deficient mice. Mech Ageing Dev 2010; 131: 270-5.
16. Giachelli CM: The emerging role of phosphate in vascular calcification. Kidney Int 2009; 75: 890-7.
17. Shroff RC, et al.: Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification. JASN 2010; 21: 103-12.
18. Shuto E, et al.: Dietary phosphorus acutely impairs endothelial function. JASN 2009; 20: 1504-12.
19. Bohn L, Meyer AS, Rasmussen SK: Phytate: impact on environment and human nutrition. A challenge for molecular breeding. J Zhejiang Univ Sci B 2008; 9: 165-91.
20. Lei XG, Porres JM: Phytase enzymology, applications, and biotechnology. Biotechnol Lett 2003; 25: 1787-94.
21. Kalantar-Zadeh K, et al.: Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney disease. CJASN 2010; 5: 519-30.
22. Sherman RA, Mehta O: Phosphorus and potassium content of enhanced meat and poultry products: implications for patients who receive dialysis. CJASN 2009; 4: 1370-3.
23. Tonelli M, Pannu N, Manns B: Oral phosphate binders in patients with kidney failure. NEJM 2010; 362: 1312-24.
24. Haut LL, et al.: Renal toxicity of phosphate in rats. Kidney Int 1980; 17: 722-31.
25. Klaus D, Hoyer J, Middeke M: Salt restriction for the prevention of cardiovascular disease. Dtsch Arztebl Int 2010; 107(26): 457-62.
26. Uribarri J: Phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus intake. Semin Dial 2007 20 295-301.
27. Ohnishi M, Razzaque MS: Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 2010; 24 3562-71
28. e3. Dhingra R, et al.: Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community. Eur J Heart Fail 2010; 12: 812-8.
29. e4. Prie D, Urena Torres P, Friedlander G: Latest findings in phosphate homeostasis. Kidney Int 2009; 75: 882-9.
30. e5. Martin KJ, Gonzalez EA: Prevention and control of phosphate retention/ hyperphosphatemia in CKD-MBD: what is normal, when to start, and how to treat? Clin J Am Soc Nephrol 2011; 6: 440-6.
31. e6. Stubbs JR, et al.: Role of hyperphosphatemia and 1,25- dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J Am Soc Nephrol 2007; 18: 2116-24.
32. e7. Moe SM, et al.: Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins. Kidney Int 2002; 61: 638-47.
33. e8. Kayne LH, et al.: Analysis of segmental phosphate absorption in intact rats. A compartmental analysis approach. J Clin Invest 1993; 91: 915-22.
34. Calvo MS, Park YK: Changing phosphorus content of the U.S. diet: potential for adverse effects on bone. J Nutr 1996 126(4 Suppl): 1168S-80S
35. Alfrey AC: The role of abnormal phosphorus metabolism in the progression of chronic kidney disease and metastatic calcifica - tion. Kidney Int Suppl 2004: S13-7