Synthesis and biological evaluation of novel 2-Arylalkylthio-5-iodine-6- substituted-benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside reverse transcriptase inhibitors

Molecules

Volumn 19, Issue 6, 2014, Pages 7104-7121

  Zhang, Liang ^a   Tang, Xiaowan ^a   Cao, Yuanyuan ^a   Wu, Shaotong ^a   Zhang, Yu ^a   Zhao, Jianxiong ^a   Guo, Ying ^a   Tian, Chao ^a   Zhang, Zhili ^a   Liu, Junyi ^a,b   Wang, Xiaowei ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Docking; HIV; IC50; NNRTIs; S DABOs

Indexed keywords

RNA DIRECTED DNA POLYMERASE INHIBITOR;

CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IC50; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903308128     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19067104     Document Type: Article

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