Dose-responsive effect of psychotropic drug use and subsequent dementia: A nationwide propensity score matched case-control study in Taiwan

Journal of the American Medical Directors Association

Volumn 15, Issue 7, 2014, Pages 509-513

  Hsiao, Fei Yuan ^a,b   Peng, Li Ning ^c,d   Lin, Ming Hsien ^c,d   Chen, Liang Kung ^c,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Case control study; Cognition; Dementia; National health insurance database; Psychotropic agents

Indexed keywords

ALPRAZOLAM; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; ESTAZOLAM; FLUNITRAZEPAM; FLUOXETINE; HALOPERIDOL; HYPNOTIC AGENT; IMIPRAMINE; LITHIUM; LORAZEPAM; NEUROLEPTIC AGENT; PROCHLORPERAZINE; QUETIAPINE; TRAZODONE; TRIAZOLAM; ZALEPLON; ZOLPIDEM; ZOPICLONE; PSYCHOTROPIC AGENT;

AGED; ARTICLE; COGNITION; CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG SAFETY; DRUG USE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION BASED CASE CONTROL STUDY; PROPENSITY SCORE; TAIWAN; CASE CONTROL STUDY; CHEMICALLY INDUCED; FACTUAL DATABASE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; DATABASES, FACTUAL; DEMENTIA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; PROPENSITY SCORE; PSYCHOTROPIC DRUGS; TAIWAN;

EID: 84903196734     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2014.02.009     Document Type: Article

References (32)

1. Woo J. Meeting the needs of an aging population in China: Public health and policy implications. JClin Gerontol Geriatr 2013, 4:31-32.
2. Miu D.K.S., Szeto S.S.L. Sleep disturbances among a group of dementia participants. JClin Gerontol Geriatr 2012, 3:105-109.
3. Chu C.L., Chen L.K. Insomnia of older people and use of benzodiazepines in Taiwan. JClin Gerontol Geriatr 2013, 4:67-68.
4. Hsiao F.Y., Hsieh P.H., Gau C.S. Ten-year trend in prescriptions of z-hypnotics among the elderly: A nationwide, cross-sectional study in Taiwan. JClin Gerontol Geriatr 2013, 4:37-41.
5. Gustafsson M., Karlsson S., Lovheim H. Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units. BMC Pharmacol Toxicol 2013, 14:10.
6. Koyama A., Steinman M., Ensrud K., et al. Ten-year trajectory of potentially inappropriate medications in very old women: Importance of cognitive status. JAm Geriatr Soc 2013, 61:258-263.
7. Fick D.M., Cooper J.W., Wade W.E., et al. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 2003, 163:2716-2724.
8. Billioti de Gage S., Begaud B., Bazin F., et al. Benzodiazepine use and risk of dementia: prospective population based study. BMJ 2012, 345:e6231.
9. Bocti C., Roy-Desruisseaux J., Hudon C., Roberge P. Benzodiazepine and dementia: A time for reflection. Maturitas 2013, 75:105-106.
10. Bocti C., Roy-Desruisseaux J., Roberge P. Research paper most likely shows that benzodiazepines are used to treat early symptoms of dementia. BMJ 2012, 345:e7986. author reply e93.
11. Barbui C., Gastaldon C., Cipriani A. Benzodiazepines and risk of dementia: true association or reverse causation?. Epidemiol Psychiatr Sci 2013, 22:307-308.
12. Gallacher J., Elwood P., Pickering J., et al. Benzodiazepine use and risk of dementia: Evidence from the Caerphilly Prospective Study (CaPS). JEpidemiol Community Health 2012, 66:869-873.
13. Paterniti S., Dufouil C., Alperovitch A. Long-term benzodiazepine use and cognitive decline in the elderly: The Epidemiology of Vascular Aging Study. JClin Psychopharmacol 2002, 22:285-293.
14. Wu C.S., Wang S.C., Chang I.S., Lin K.M. The association between dementia and long-term use of benzodiazepine in the elderly: Nested case-control study using claims data. Am J Geriatr Psychiatry 2009, 17:614-620.
15. Verdoux H., Lagnaoui R., Begaud B. Is benzodiazepine use a risk factor for cognitive decline and dementia? A literature review of epidemiological studies. Psychol Med 2005, 35:307-315.
16. Lagnaoui R., Begaud B., Moore N., et al. Benzodiazepine use and risk of dementia: a nested case-control study. JClin Epidemiol 2002, 55:314-318.
17. Gallacher J., Bayer A., Fish M., et al. Does anxiety affect risk of dementia? Findings from the Caerphilly Prospective Study. Psychosom Med 2009, 71:659-666.
18. Amieva H., Le Goff M., Millet X., et al. Prodromal Alzheimer's disease: Successive emergence of the clinical symptoms. Ann Neurol 2008, 64:492-498.
19. Ntaional Health Research Institute. National Health Insurance Database (NHIRD). Available at: Acessed July 15,2013. http://nhird.nhri.org.tw/en/Data_Subsets.html#S3.
20. International Classification of Diseases, Ninth Revision (ICD-9). World Health Organization2011.
21. Hsiao F.Y., Yang C.L., Huang Y.T., Huang W.F. Using Taiwan's national health insurance research databases for pharmacoepidemiology research. JFood Drug Anal 2007, 15:99-108.
22. Chen Y.M., Chen D.Y., Chen L.K., et al. Alendronate and risk of esophageal cancer: a nationwide population-based study in Taiwan. JAm Geriatr Soc 2011, 59:2379-2381.
23. Hsiao F.Y., Huang W.F., Chen Y.M., et al. Hip and subtrochanteric or diaphyseal femoral fractures in alendronate users: A 10-year, nationwide retrospective cohort study in Taiwanese women. Clin Ther 2011, 33:1659-1667.
24. Huang W.F., Tsai Y.W., Wen Y.W., et al. Osteoporosis treatment and atrial fibrillation: alendronate versus raloxifene. Menopause 2010, 17:57-63.
25. Lin C.F., Wu F.L., Lin S.W., et al. Age, dementia and care patterns after admission for acute coronary syndrome: An analysis from a nationwide cohort under the national health insurance coverage. Drugs Aging 2012, 29:819-828.
26. WHO Collaborating Center for Drug Statistics Methodology, Anatomical Therapeutic Chemical (ATC) classification index with defined daily doses (DDDs), 2013. Oslo2013.
27. Mazzucco S., Cipriani A., Barbui C., Monaco S. Antipsychotic drugs and cerebrovascular events in elderly patients with dementia: A systematic review. Mini Rev Med Chem 2008, 8:776-783.
28. Lagnaoui R., Tournier M., Moride Y., et al. The risk of cognitive impairment in older community-dwelling women after benzodiazepine use. Age Ageing 2009, 38:226-228.
29. Potvin O., Hudon C., Dion M., et al. Anxiety disorders, depressive episodes and cognitive impairment no dementia in community-dwelling older men and women. Int J Geriatr Psychiatry 2011, 26:1080-1088.
30. Wu K.Y., Chang C.M., Liang H.Y., et al. Increased risk of developing dementia in patients with bipolar disorder: A nested matched case-control study. Bipolar Disord 2013, 15:787-794.
31. Liperoti R., Pedone C., Corsonello A. Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD). Curr Neuropharmacol 2008, 6:117-124.
32. Sink K.M., Holden K.F., Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA 2005, 293:596-608.