HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region

Circulation Research

Volumn 115, Issue 1, 2014, Pages 23-31

  Dykes, Iain M ^a,f   Van Bueren, Kelly Lammerts ^a   Ashmore, Rebekah J ^a   Floss, Thomas ^b,c   Wurst, Wolfgang ^b,c,d,e   Szumska, Dorota ^f   Bhattacharya, Shoumo ^f   Scambler, Peter J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

22q11 deletion syndrome; developmental biology; genetics; heart septal defects, ventricular; HIC2 protein, human; Mesp1 protein, mouse; models, animal

Indexed keywords

TRANSCRIPTION FACTOR;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BMP10 GENE; CELL LINEAGE; CHROMOSOME DELETION 22Q11; CONGENITAL HEART DISEASE; CONTROLLED STUDY; EMBRYO; GENE; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; GENE MAPPING; HAPLOINSUFFICIENCY; HEART DEVELOPMENT; HEART VENTRICLE SEPTUM DEFECT; HEMIZYGOSITY; HETEROZYGOSITY; HIC2 GENE; HOMOZYGOSITY; LETHALITY; MESP1 GENE; MICROARRAY ANALYSIS; MOUSE; NKX2.5 GENE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PRIORITY JOURNAL; PROGENITOR CELL LINE; REPORTER GENE; TBX1 GENE;

22Q11 DELETION SYNDROME; DEVELOPMENTAL BIOLOGY; GENETICS; HEART SEPTAL DEFECTS, VENTRICULAR; HIC2 PROTEIN, HUMAN; MESP1 PROTEIN, MOUSE; MODELS, ANIMAL;

22Q11 DELETION SYNDROME; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE MORPHOGENETIC PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEART; HEART DEFECTS, CONGENITAL; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MORPHOGENESIS; MUTAGENESIS; NUCLEAR PROTEINS; T-BOX DOMAIN PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 84903169684     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.303300     Document Type: Article

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