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Volumn 10, Issue 7, 2014, Pages 1147-1155

Ofatumumab as front-line therapy in untreated chronic lymphocytic leukemia

Author keywords

chronic lymphocytic leukemia; immunotherapy; monoclonal antibodies; ofatumumab; untreated

Indexed keywords

ALEMTUZUMAB; BENDAMUSTINE; CASPASE; CD20 ANTIBODY; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; FLUDARABINE; FLUDARABINE PHOSPHATE; IBRUTINIB; IDELALISIB; LENALIDOMIDE; MEMBRANE ANTIGEN; OFATUMUMAB; PENTOSTATIN; RITUXIMAB; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

EID: 84903167043     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.14.73     Document Type: Article
Times cited : (8)

References (47)
  • 1
    • 84903143381 scopus 로고    scopus 로고
    • The Leukemia & Lymphoma Society. Facts 2013
    • The Leukemia & Lymphoma Society. Facts 2013. www.lls.org/content/ nationalcontent/resourcecenter/freeeducat ion materials/generalcancer/pdf/facts. pdf
  • 2
    • 4444250628 scopus 로고    scopus 로고
    • Risk of non-Hodgkin's lymphoma and family history of lymphatic, hematologic, and other cancers
    • Chatterjee N, Hartge P, Cerhan JR et al. Risk of non-Hodgkin's lymphoma and family history of lymphatic, hematologic, and other cancers. Cancer Epidemiol. Biomarkers Prev. 13, 1415-1421 (2004).
    • (2004) Cancer Epidemiol. Biomarkers Prev. , vol.13 , pp. 1415-1421
    • Chatterjee, N.1    Hartge, P.2    Cerhan, J.R.3
  • 3
    • 33846252870 scopus 로고    scopus 로고
    • Non-Hodgkin's lymphoma and family history of hematologic malignancy
    • Mensah FK, Willett EV, Ansell P et al. Non-Hodgkin's lymphoma and family history of hematologic malignancy. Am. J. Epidemiol. 165, 126-133 (2007).
    • (2007) Am. J. Epidemiol. , vol.165 , pp. 126-133
    • Mensah, F.K.1    Willett, E.V.2    Ansell, P.3
  • 4
    • 77958182539 scopus 로고    scopus 로고
    • Association between red blood cell transfusions and development of non-Hodgkin lymphoma: A meta-analysis of observational studies
    • Castillo JJ, Dalia S, Pascual SK. Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies. Blood 116, 2897-2907 (2010).
    • (2010) Blood , vol.116 , pp. 2897-2907
    • Castillo, J.J.1    Dalia, S.2    Pascual, S.K.3
  • 5
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fudarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, Phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G et al. Addition of rituximab to fudarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, Phase 3 trial. Lancet 376, 1164-1174 (2010).
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 6
    • 84860630561 scopus 로고    scopus 로고
    • Minimal residual disease quantifcation is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: A multivariate analysis from the randomized GCLLSG CLL8 trial
    • Bottcher S, Ritgen M, Fischer K et al. Minimal residual disease quantifcation is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: a multivariate analysis from the randomized GCLLSG CLL8 trial. J. Clin. Oncol. 30, 980-988 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 980-988
    • Bottcher, S.1    Ritgen, M.2    Fischer, K.3
  • 7
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as frst-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T et al. Alemtuzumab compared with chlorambucil as frst-line therapy for chronic lymphocytic leukemia. J. Clin. Oncol. 25, 5616-5623 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 8
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J. Clin. Oncol. 27, 4378-4384 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 9
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N. Engl. J. Med. 343, 1750-1757 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 10
    • 69849107362 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab in fudarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
    • Stilgenbauer S, Zenz T, Winkler D et al. Subcutaneous alemtuzumab in fudarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J. Clin. Oncol. 27, 3994-4001 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3994-4001
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3
  • 11
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 369, 32-42 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 12
    • 77950478885 scopus 로고    scopus 로고
    • Rituximab plus fudarabine and cyclophosphamide prolongs progression-free survival compared with fudarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia
    • Robak T, Dmoszynska A, Solal-Celigny P et al. Rituximab plus fudarabine and cyclophosphamide prolongs progression-free survival compared with fudarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J. Clin. Oncol. 28, 1756-1765 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1756-1765
    • Robak, T.1    Dmoszynska, A.2    Solal-Celigny, P.3
  • 13
    • 84887058701 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) plus chlorambucil (Clb) or rituximab (R) plus Clb versus Clb alone in patients with chronic lymphocytic leukemia (CLL) and preexisting medical conditions (comorbidities): Fnal stage 1 results of the CLL11 (BO21004) Phase III trial
    • Goede V, Fischer K, Humphrey K et al. Obinutuzumab (GA101) plus chlorambucil (Clb) or rituximab (R) plus Clb versus Clb alone in patients with chronic lymphocytic leukemia (CLL) and preexisting medical conditions (comorbidities): fnal stage 1 results of the CLL11 (BO21004) Phase III trial. ASCO Meeting Abstracts 31, 7004 (2013).
    • ASCO Meeting Abstracts , vol.31 , Issue.7004 , pp. 2013
    • Goede, V.1    Fischer, K.2    Humphrey, K.3
  • 14
    • 33947243663 scopus 로고    scopus 로고
    • Clinical effcacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a Phase II st udy
    • Chanan-Khan A, Miller KC, Musial L et al. Clinical effcacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a Phase II st udy. J. Clin. Oncol. 24, 5343-5349 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5343-5349
    • Chanan-Khan, A.1    Miller, K.C.2    Musial, L.3
  • 15
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman RR, Sharman JP, Coutre SE et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 370(11), 997-1007 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , Issue.11 , pp. 997-1007
    • Furman, R.R.1    Sharman, J.P.2    Coutre, S.E.3
  • 16
    • 77950331000 scopus 로고    scopus 로고
    • CD20 as a target for therapeutic type i and II monoclonal antibodies
    • Beers SA, Chan CHT, French RR et al. CD20 as a target for therapeutic type I and II monoclonal antibodies. Semin. Hematol. 47, 107-114 (2010).
    • (2010) Semin. Hematol. , vol.47 , pp. 107-114
    • Beers, S.A.1    Cht, C.2    French, R.R.3
  • 17
    • 0035760902 scopus 로고    scopus 로고
    • CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: Further regulation by CD55 and CD59
    • Golay J, Lazzari M, Facchinetti V et al. CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59. Blood 98, 3383-3389 (2001).
    • (2001) Blood , vol.98 , pp. 3383-3389
    • Golay, J.1    Lazzari, M.2    Facchinetti, V.3
  • 18
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D, von Schilling C, Wilhelm M et al. Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood 98, 1326-1331 (2001).
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    Von Schilling, C.2    Wilhelm, M.3
  • 19
    • 0038811776 scopus 로고    scopus 로고
    • Single-Agent Rituximab as First-Line and Maintenance Treatment for Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma: A Phase II Trial of the Minnie Pearl Cancer Research Network
    • Hainsworth JD, Litchy S, Barton JH et al. Single-Agent Rituximab as First-Line and Maintenance Treatment for Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma: a Phase II Trial of the Minnie Pearl Cancer Research Network. J. Clin. Oncol. 21, 1746-1751 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3
  • 20
    • 1342282157 scopus 로고    scopus 로고
    • Rituximab Infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia
    • Kennedy AD, Beum PV, Solga MD et al. Rituximab Infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia. J. Immunol. 172, 3280-3288 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 3280-3288
    • Kennedy, A.D.1    Beum, P.V.2    Solga, M.D.3
  • 21
    • 32044464340 scopus 로고    scopus 로고
    • The shaving reaction: Rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes
    • Beum PV, Kennedy AD, Williams ME et al. The shaving reaction: rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes. J. Immunol. 176, 2600-2609 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 2600-2609
    • Beum, P.V.1    Kennedy, A.D.2    Williams, M.E.3
  • 22
    • 0037306946 scopus 로고    scopus 로고
    • Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts
    • Cragg MS, Morgan SM, Chan HT et al. Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts. Blood 101, 1045-1052 (2003).
    • (2003) Blood , vol.101 , pp. 1045-1052
    • Cragg, M.S.1    Morgan, S.M.2    Chan, H.T.3
  • 23
    • 0141704595 scopus 로고    scopus 로고
    • CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100 insoluble membrane rafts
    • Chan HTC, Hughes D, French RR et al. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100 insoluble membrane rafts. Cancer Res. 63, 5480-5489 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 5480-5489
    • Htc, C.1    Hughes, D.2    French, R.R.3
  • 24
    • 0036464611 scopus 로고    scopus 로고
    • The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
    • Byrd JC, Kitada S, Flinn IW et al. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. Blood 99, 1038-1043 (2002).
    • (2002) Blood , vol.99 , pp. 1038-1043
    • Byrd, J.C.1    Kitada, S.2    Flinn, I.W.3
  • 25
    • 84885671483 scopus 로고    scopus 로고
    • Preclinical activity of the Type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
    • Herter S, Herting F, Mundigl O et al. Preclinical activity of the Type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models. Mol. Cancer Ther. 12, 2031-2042 (2013).
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 2031-2042
    • Herter, S.1    Herting, F.2    Mundigl, O.3
  • 26
    • 84874835426 scopus 로고    scopus 로고
    • Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties
    • Rafq S, Butchar JP, Cheney C et al. Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties. J. Immunol. 190, 2702-2711 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 2702-2711
    • Rafq, S.1    Butchar, J.P.2    Cheney, C.3
  • 27
    • 4444343395 scopus 로고    scopus 로고
    • Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
    • Teeling JL, French RR, Cragg MS et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 104, 1793-1800 (2004).
    • (2004) Blood , vol.104 , pp. 1793-1800
    • Teeling, J.L.1    French, R.R.2    Cragg, M.S.3
  • 28
    • 77956250271 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration approval: Ofatumumab for the treatment of patients with chronic lymphocytic leukemia refractory to fudarabine and alemtuzumab
    • Lemery SJ, Zhang J, Rothmann MD et al. U.S. Food and Drug Administration approval: ofatumumab for the treatment of patients with chronic lymphocytic leukemia refractory to fudarabine and alemtuzumab. Clin. Cancer Res. 16, 4331-4338 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4331-4338
    • Lemery, S.J.1    Zhang, J.2    Rothmann, M.D.3
  • 29
    • 33745324686 scopus 로고    scopus 로고
    • The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    • Teeling JL, Mackus WJ, Wiegman LJ et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J. Immunol. 177, 362-371 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 362-371
    • Teeling, J.L.1    Mackus, W.J.2    Wiegman, L.J.3
  • 30
    • 84896716648 scopus 로고    scopus 로고
    • Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia
    • Baig NA, Taylor RP, Lindorfer MA et al. Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia. J. Immunol. 192, 1620-1629 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 1620-1629
    • Baig, N.A.1    Taylor, R.P.2    Lindorfer, M.A.3
  • 31
    • 84871831846 scopus 로고    scopus 로고
    • Ofatumumab is more effcient than rituximab in lysing B chronic lymphocytic leukemia cells in whole blood and in combination with chemotherapy
    • Bologna L, Gotti E, Da Roit F et al. Ofatumumab is more effcient than rituximab in lysing B chronic lymphocytic leukemia cells in whole blood and in combination with chemotherapy. J. Immunol. 190, 231-239 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 231-239
    • Bologna, L.1    Gotti, E.2    Da Roit, F.3
  • 32
    • 68949129063 scopus 로고    scopus 로고
    • Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): Considerably higher levels of CDC are induced by OFA than by RTX
    • Pawluczkowycz AW, Beurskens FJ, Beum PV et al. Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX. J. Immunol. 183, 749-758 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 749-758
    • Pawluczkowycz, A.W.1    Beurskens, F.J.2    Beum, P.V.3
  • 33
    • 84886816138 scopus 로고    scopus 로고
    • Killing of CLL and NHL cells by rituximab and ofatumumab under limited availability of complement
    • Okroj M, Eriksson I, Osterborg A, Blom AM. Killing of CLL and NHL cells by rituximab and ofatumumab under limited availability of complement. Med. Oncol. 30, 759 (2013).
    • Med. Oncol. , vol.30 , Issue.759 , pp. 2013
    • Okroj, M.1    Eriksson, I.2    Osterborg, A.3    Blom, A.M.4
  • 34
    • 84889808921 scopus 로고    scopus 로고
    • Complement factor H-derived short consensus repeat 18-20 enhanced complement-dependent cytotoxicity of ofatumumab on chronic lymphocytic leukemia cells
    • Hörl S, Banki Z, Huber G et al. Complement factor H-derived short consensus repeat 18-20 enhanced complement-dependent cytotoxicity of ofatumumab on chronic lymphocytic leukemia cells. Haematologica 98, 1939-1947 (2013).
    • (2013) Haematologica , vol.98 , pp. 1939-1947
    • Hörl, S.1    Banki, Z.2    Huber, G.3
  • 35
    • 77953517111 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacokinetic/pharmacodynamic associations of ofatumumab, a human monoclonal CD20 antibody, in patients with relapsed or refractory chronic lymphocytic leukaemia: A Phase 1-2 study
    • Coiffer B, Losic N, Rønn BB et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic associations of ofatumumab, a human monoclonal CD20 antibody, in patients with relapsed or refractory chronic lymphocytic leukaemia: a Phase 1-2 study. Br. J. Haematol. 150, 58-71 (2010).
    • (2010) Br. J. Haematol. , vol.150 , pp. 58-71
    • Coiffer, B.1    Losic, N.2    Rønn, B.B.3
  • 36
    • 84902003421 scopus 로고    scopus 로고
    • Population pharmacokinetics of ofatumumab in patients with chronic lymphocytic leukemia, follicular lymphoma, and rheumatoid arthritis
    • doi:10.1002/jcph.268 Epub ahead of print
    • Struemper H, Sale M, Patel BR et al. Population pharmacokinetics of ofatumumab in patients with chronic lymphocytic leukemia, follicular lymphoma, and rheumatoid arthritis. J. Clin. Pharmacol. doi:10.1002/jcph.268 (2014) (Epub ahead of print).
    • (2014) J. Clin. Pharmacol
    • Struemper, H.1    Sale, M.2    Patel, B.R.3
  • 37
    • 38949185742 scopus 로고    scopus 로고
    • Safety and effcacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A Phase 1-2 study
    • Coiffer B, Lepretre S, Pedersen LM et al. Safety and effcacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a Phase 1-2 study. Blood 111, 1094-1100 (2008).
    • (2008) Blood , vol.111 , pp. 1094-1100
    • Coiffer, B.1    Lepretre, S.2    Pedersen, L.M.3
  • 38
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-agent CD20 immunotherapy in fudarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J et al. Ofatumumab as single-agent CD20 immunotherapy in fudarabine-refractory chronic lymphocytic leukemia. J. Clin. Oncol. 28, 1749-1755 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1749-1755
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 39
    • 84903148562 scopus 로고    scopus 로고
    • Phase II trial of ofatumumab (OFA) for older patients and patients who refuse fudarabine-based regimens with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
    • Atlanta, GA, USA, 8-11 December 2012 (Abstract 719
    • Flinn IW, Harwin WN, Ward P et al. Phase II trial of ofatumumab (OFA) for older patients and patients who refuse fudarabine-based regimens with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Presented at: 54th ASH Annual Meeting and Exposition. Atlanta, GA, USA, 8-11 December 2012 (Abstract 719).
    • Presented At: 54th ASH Annual Meeting and Exposition
    • Flinn, I.W.1    Harwin, W.N.2    Ward, P.3
  • 40
    • 79959190996 scopus 로고    scopus 로고
    • Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Dürig J et al. Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia. Blood 117, 6450-6458 (2011).
    • (2011) Blood , vol.117 , pp. 6450-6458
    • Wierda, W.G.1    Kipps, T.J.2    Dürig, J.3
  • 41
    • 84886099199 scopus 로고    scopus 로고
    • Ofatumumab-based chemoimmunotherapy is effective and well tolerated in patients with previously untreated chronic lymphocytic leukemia (CLL)
    • Shanafelt T, Lanasa MC, Call TG et al. Ofatumumab-based chemoimmunotherapy is effective and well tolerated in patients with previously untreated chronic lymphocytic leukemia (CLL). Cancer 119, 3788-3796 (2013).
    • (2013) Cancer , vol.119 , pp. 3788-3796
    • Shanafelt, T.1    Lanasa, M.C.2    Call, T.G.3
  • 42
    • 84903140769 scopus 로고    scopus 로고
    • A Phase II multi-center trial of pentostatin plus cyclophosphamide with ofatumumab (PCO) in older previously untreated chronic lymphocytic leukemia (CLL) patients
    • New Orleans, LA, USA, 7-10 December 2013 (Abstract 4177
    • Montillo M, Rossi D, Motta M et al. A Phase II multi-center trial of pentostatin plus cyclophosphamide with ofatumumab (PCO) In older previously untreated chronic lymphocytic leukemia (CLL) patients. Presented at: 55th ASH Annual Meeting and Exposition. New Orleans, LA, USA, 7-10 December 2013 (Abstract 4177).
    • Presented At: 55th ASH Annual Meeting and Exposition
    • Montillo, M.1    Rossi, D.2    Motta, M.3
  • 43
    • 84903122103 scopus 로고    scopus 로고
    • Early ofatumumab treatment for high-risk, treatment-naive patients with chronic lymphocytic leukemia
    • New Orleans, LA, USA, 7-10 December 2013 (Abstract 5307
    • Keating MJ, Ferrajoli A, Konopleva M et al. Early ofatumumab treatment for high-risk, treatment-naive patients with chronic lymphocytic leukemia. Presented at: 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA 7-10 December 2013 (Abstract 5307).
    • Presented At: 55th ASH Annual Meeting and Exposition
    • Keating, M.J.1    Ferrajoli, A.2    Konopleva, M.3
  • 44
    • 84896345679 scopus 로고    scopus 로고
    • Ofatumumab + chlorambucil versus chlorambucil alone in patients with untreated chronic lymphocytic leukemia (CLL): Results of the Phase III study complement 1 (OMB110911)
    • New Orleans, LA, USA, 7-10 December 2013 (Abstract 528
    • Hillmen P, Robak T, Janssens A et al. Ofatumumab + chlorambucil versus chlorambucil alone in patients with untreated chronic lymphocytic leukemia (CLL): results of the Phase III study complement 1 (OMB110911). Presented at: 55th ASH Annual Meeting and Exposition. New Orleans, LA, USA, 7-10 December 2013 (Abstract 528)
    • Presented At: 55th ASH Annual Meeting and Exposition
    • Hillmen, P.1    Robak, T.2    Janssens, A.3
  • 45
    • 84903198038 scopus 로고    scopus 로고
    • UpToDate: Ofatumumab: drug information
    • UpToDate: Ofatumumab: drug information. www.uptodate.com/contents/ ofatumumab-drug-information?source = see-link
  • 46
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows signifcant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • Kay NE, Geyer SM, Call TG et al. Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows signifcant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood 109, 405-411 (2007).
    • (2007) Blood , vol.109 , pp. 405-411
    • Kay, N.E.1    Geyer, S.M.2    Call, T.G.3
  • 47
    • 84896443806 scopus 로고    scopus 로고
    • A multicenter Phase IV observational study of ofatumumab in chronic lymphocytic leukemia (CLL): A European Research Initiative on CLL (ERIC) study
    • Moreno C, Montillo M, Panayiotis P et al. A multicenter, Phase IV observational study of ofatumumab in chronic lymphocytic leukemia (CLL): a European Research Initiative On CLL (ERIC) study. Blood 122(21), Abstract 1645 (2013).
    • (2013) Blood , vol.122 , Issue.21 , pp. 1645
    • Moreno, C.1    Montillo, M.2    Panayiotis, P.3


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