Botulinum toxin versus botulinum toxin with low-dose glyceryltrinitrate for healing of chronic anal fissure: A prospective, randomised trial

New Zealand Medical Journal

Volumn 127, Issue 1393, 2014, Pages 80-86

  Asim, Muhammad ^a   Lowrie, Neil ^a   Stewart, Joanna ^b   Lolohea, Simi ^a   Van Dalen, Ralph ^a  

^a WAIKATO HOSPITAL   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; GLYCERYL TRINITRATE; ANTIPARKINSON AGENT; VASODILATOR AGENT;

ADULT; AGED; ANORECTAL PRESSURE; ANUS FISSURE; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG POTENTIATION; DRUG WITHDRAWAL; EVALUATION AND FOLLOW UP; FECES INCONTINENCE; FEMALE; FLATULENCE; HEADACHE; HUMAN; LOW DRUG DOSE; MALE; MIDDLE AGED; PAIN ASSESSMENT; QUESTIONNAIRE; SCORING SYSTEM; SENSITIVITY ANALYSIS; WOUND HEALING; ADOLESCENT; CHRONIC DISEASE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DRUG COMBINATION; DRUG EFFECT; INJECTION; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VERY ELDERLY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-DYSKINESIA AGENTS; BOTULINUM TOXINS; CHRONIC DISEASE; DRUG THERAPY, COMBINATION; FEMALE; FISSURE IN ANO; HUMANS; INJECTIONS; MALE; MIDDLE AGED; NITROGLYCERIN; PAIN MEASUREMENT; TREATMENT OUTCOME; VASODILATOR AGENTS; WOUND HEALING;

EID: 84903147619     PISSN: 00288446     EISSN: 11758716     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Shub HA, Salvati EP, Rubin RJ. Conservative treatment of anal fissure: an unselected, retrospective and continuous study. Dis Colon Rectum 1978;21:582.
2. Fleshman JW. Anorectal motor physiology and pathophysiology. Surg Clin North Am. 1993 Dec;73(6):1245–1265.
3. Nelson R. Operative procedures for fissure in ano. Cochrane Database Syst Rev 2005;CD002199.
4. Chakder S, Rattan S. Release of nitric oxide by activation of nonadrenergic noncholinergic neurons of internal anal sphincter. Am J Physiol. 1993 Jan;264(1 Pt 1):G7–12.
5. Lund JN, Armitage NC, Scholefield JH. Use of glyceryl trinitrate ointment in the treatment of anal fissure. Br J Surg. 1996 Jun;83(6):776–777.
6. Maria G, Cassetta E, Gui D, et al. A comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med. 1998 Jan 22;338(4):217–220
7. Lysy J, Israelit-Yatzkan Y, Sestiery-Ittah M, et al. Topical nitrates potentiates the effect of botulinum toxin in the treatment of patients with refractory anal fissure. Gut 2001;48:221.
8. Scholefield JH, Bock JU, Marla B, et al. A dose finding study with 0.1%, 0.2% and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures. GUT. 2003 February; 52(2):264-269
9. Lund JN, Scholefield JH. Glyceryl trinitrate ointment for chronic anal fissure (letter). Lancet 1997;349:573.
10. Jorge J, Wexner S. Etiology and management of fecal incontinence. Dis Colon Rectum 1993;36:77-97.
11. Kennedy ML, Sowter S, Nguyen H, et al. Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up. Dis Colon Rectum. 1999 Aug;42(8):1000-6.
12. Altomare DF, Rinaldi M, Milito G, et al. Glyceryl trinitrate for chronic anal fissure—healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. Dis Colon Rectum 2000; 43:174.