Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. clopidogrel in patients with acute coronary syndromes managed without revascularization: Insights from the TRILOGY ACS trial

American Heart Journal

Volumn 168, Issue 1, 2014, Pages

  Cornel, Jan H ^a   Ohman, E Magnus ^b,c   Neely, Benjamin ^b   Clemmensen, Peter ^d   Sritara, Piyamitr ^e   Zamoryakhin, Dmitry ^f   Armstrong, Paul W ^g   Prabhakaran, Dorairaj ^h   White, Harvey D ⁱ   Fox, Keith A A ^j   Gurbel, Paul A ^k   Roe, Matthew T ^b,c  

^a Northwest Clinics   (Netherlands)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e MAHIDOL UNIVERSITY   (Thailand)

^f DAIICHI SANKYO CO   (Japan)

^g UNIVERSITY OF ALBERTA   (Canada)

^h CENTRE FOR CHRONIC DISEASE CONTROL   (India)

ⁱ AUCKLAND CITY HOSPITAL   (New Zealand)

^j UNIVERSITY OF EDINBURGH   (United Kingdom)

^k SINAI CENTER FOR THROMBOSIS RESEARCH   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; PRASUGREL;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; COMORBIDITY; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PLATELET REACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION; SMOKING; THROMBOCYTE FUNCTION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ACUTE CORONARY SYNDROME; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL REVASCULARIZATION; PIPERAZINES; PLATELET AGGREGATION INHIBITORS; PROGNOSIS; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RETROSPECTIVE STUDIES; SMOKING; SURVIVAL RATE; THIOPHENES; TICLOPIDINE; TIME FACTORS; TREATMENT OUTCOME; UNITED STATES;

EID: 84903130512     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2014.04.011     Document Type: Article

References (24)

1. D. Waters, J. Lesperance, and P. Gladstone et al. Effects of cigarette smoking on the angiographic evolution of coronary atherosclerosis: a Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) Substudy Circulation 94 1996 614 621 (Pubitemid 26289213)
2. R.E. Vlietstra, R.A. Kronmal, and A. Oberman et al. Effect of cigarette smoking on survival of patients with angiographically documented coronary artery disease: report from the CASS registry JAMA 255 1986 1023 1027 (Pubitemid 16164149)
3. D. Hasdai, K.N. Garratt, and D.E. Grill et al. Effect of smoking status on the long-term outcome after successful percutaneous coronary revascularization N Engl J Med 336 1997 755 761 (Pubitemid 27113969)
4. J.A. Ambrose, and R.S. Barua The pathophysiology of cigarette smoking and cardiovascular disease: an update J Am Coll Cardiol 43 2004 1731 1737 (Pubitemid 38622506)
5. C. Willi, P. Bodenmann, and W.A. Ghali et al. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis JAMA 298 2007 2654 2664 (Pubitemid 350254957)
6. S.A. Harding, J. Sarma, and D.H. Josephs et al. Upregulation of the CD40/CD40 ligand dyad and platelet-monocyte aggregation in cigarette smokers Circulation 109 2004 1926 1929 (Pubitemid 38544479)
7. J. Hung, J.Y.T. Lam, and L. Lacoste et al. Cigarette smoking acutely increases platelet thrombus formation in patients with coronary artery disease taking aspirin Circulation 92 1995 2432 2436
8. J.H. Cornel, R.C. Becker, and S.G. Goodman et al. Prior smoking status, clinical outcomes, and the comparison of ticagrelor with clopidogrel in acute coronary syndromes-Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial Am Heart J 164 2012 334 342
9. S. Matetzky, B. Shenkman, and V. Guetta et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction Circulation 109 2004 3171 3175
10. K.P. Bliden, J. Dichiara, and L. Lawal et al. The association of cigarette smoking with enhanced platelet inhibition by clopidogrel J Am Coll Cardiol 52 2008 531 533
11. L.A. Kroon Drug interactions with smoking Am J Health Syst Pharm 64 2007 1917 1921 (Pubitemid 47462906)
12. N.R. Desai, J.L. Mega, and S. Jiang et al. Interaction between cigarette smoking and clinical benefit of clopidogrel J Am Coll Cardiol 53 2009 1273 1278
13. 12 receptor antagonist activity Semin Thromb Hemost 31 2005 184 194 (Pubitemid 40605193)
14. S.D. Wiviott, E. Braunwald, and C.H. McCabe et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes N Engl J Med 357 2007 2001 2015 (Pubitemid 350106708)
15. P.A. Gurbel, K.P. Bliden, and D.K. Logan et al. The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: The PARADOX study J Am Coll Cardiol 62 2013 505 512
16. C.T. Chin, M.T. Roe, and K.A. Fox et al. Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial Am Heart J 160 2010 16 22.e1
17. M.T. Roe, P.W. Armstrong, and K.A.A. Fox et al. Prasugrel versus clopidogrel for ACS patients managed without revascularization N Engl J Med 367 2012 1297 1309
18. P.A. Gurbel, D. Erlinge, and M. Ohman et al. The relationship of serial platelet function measurements with clinical outcomes during long-term treatment with prasugrel and clopidogrel therapy for patients with acute coronary syndromes managed without revascularization; Insights from the TRILOGY-ACS trial JAMA 308 2012 1785 1794
19. W. Hochholzer, D. Trenk, and J.L. Mega et al. Impact of smoking on antiplatelet effect of clopidogrel and prasugrel after loading dose and on maintenance therapy Am Heart J 162 2011 518 526.e5
20. G. Shanker, J.L. Kontos, and D.M. Eckman et al. Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts J Thromb Thrombolysis 22 2006 213 220 (Pubitemid 44857783)
21. K.W. Park, J.J. Park, and K.H. Jeon et al. Enhanced clopidogrel responsiveness in smokers: smokers' paradox is dependent on cytochrome P450 CYP1A2 status Arterioscler Thromb Vasc Biol 31 2011 665 671
22. J.L. Ferreiro, D.L. Bhatt, and M. Ueno et al. Impact of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: Insights from the CAPRIE trial (Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events) J Am Coll Cardiol 63 2014 769 777
23. M. Sibbald, A.T. Yan, and W. Huang et al. Association between smoking, outcomes, and early clopidogrel use in patients with acute coronary syndrome: insights from the global registry of acute coronary events Am Heart J 160 2010 855 861
24. M.T. Roe, S.G. Goodman, and E.M. Ohman et al. Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel Circulation 128 2013 823 833