Exposure of hepatocellular carcinoma cells to low-level As2O3[U+200E] causes an extra toxicity pathway via L1 retrotransposition [U+200E]induction

Toxicology Letters

Volumn 229, Issue 1, 2014, Pages 111-117

  Karimi, Abbas ^a   Madjd, Zahra ^a   Habibi, Laleh ^b   Akrami, Seyed Mohammad ^b  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytotoxicity; Human hepatocellular carcinoma cell; LINE 1; Retrotransposition

Indexed keywords

ARSENIC TRIOXIDE; ENHANCED GREEN FLUORESCENT PROTEIN;

ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA TRANSPOSITION; FLUORESCENCE ACTIVATED CELL SORTING; GENE ACTIVATION; GENE DOSAGE; GENE FREQUENCY; GENE INDUCTION; HEP 2 CELL LINE; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MTT ASSAY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RETROPOSON;

AS(2)O(3); CYTOTOXICITY; HUMAN HEPATOCELLULAR CARCINOMA CELL; LINE-1; RETROTRANSPOSITION;

ANIMALS; ARSENICALS; CELL LINE, TUMOR; CELL SURVIVAL; COLORING AGENTS; DEOXYRIBONUCLEASE I; DNA; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; HUMANS; INDICATORS AND REAGENTS; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MICROSCOPY, FLUORESCENCE; OXIDES; PLASMIDS; REAL-TIME POLYMERASE CHAIN REACTION; RETROELEMENTS; TETRAZOLIUM SALTS; THIAZOLES; TRANSFECTION;

EID: 84903127326     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.05.025     Document Type: Article

References (34)

1. Ahsan H., Chen Y., Parvez F., Zablotska L., Argos M., Hussain I., Momotaj H., Levy D., Cheng Z., Slavkovich V., van Geen A., Howe G.R., Graziano J.H. Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Am. J. Epidemiol. 2006, 163:1138-1148.
2. Andrew A.S., Burgess J.L., Meza M.M., Demidenko E., Waugh M.G., Hamilton J.W., Karagas M.R. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ. Health Perspect. 2006, 114:1193-1198.
3. ATSDR Agency for Toxic Substances and Disease Registry. Toxicological Profile for Arsenic, Draft for Public Comment 2007, 30333. Atlanta, Georgia.
4. Babushok D.V., Kazazian H.H. Progress in understanding the biology of the human mutagen LINE-1. Hum. Mutat. 2007, 28:527-539.
5. Bharadwaj L., Dhami K., Schneberger D., Stevens M., Renaud C., Ali A. Altered gene expression in human hepatoma HepG2 cells exposed to low-level 2,4-dichlorophenoxyacetic acid and potassium nitrate. Toxicol. In Vitro 2005, 19:603-619.
6. Breccia M., Lo-Coco F. Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease. Expert Opin. Pharmacother. 2012, 13:1031-1043.
7. Cordaux R., Batzer M.A. The impact of retrotransposons on human genome evolution. Nat. Rev. Genet. 2009, 10:691-703.
8. Dastgiri S., Mosaferi M., Fizi M.A., Olfati N., Zolali S., Pouladi N., Azarfam P. Arsenic exposure, dermatological lesions, hypertension, and chromosomal abnormalities among people in a rural community of northwest Iran. J. Health Popul. Nutr. 2010, 28:14-22.
9. Del Re B., Giorgi G. Cell-host, LINE and environment: three players in search of a balance. Mobile Gene. Elem. 2013, 3:e24040.
10. Del Re B., Marcantonio P., Capri M., Giorgi G. Evaluation of LINE-1 mobility in neuroblastoma cells by in vitro retrotransposition reporter assay: FACS analysis can detect only the tip of the iceberg of the inserted L1 elements. Exp. Cell Res. 2010, 316:3358-3367.
11. Farkash E.A., Kao G.D., Horman S.R., Prak E.T. Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay. Nucl. Acids Res. 2006, 34:1196-1204.
12. Giorgi G., Marcantonio P., Del Re B. LINE-1 retrotransposition in human neuroblastoma cells is affected by oxidative stress. Cell Tissue Res. 2011, 346:383-391.
13. Habibi L., Shokrgozar M.A., Motamedi M., Akrami S.M. Effect of heavy metals on silencing of engineered long interspersed element-1 retrotransposon retrotransposon in nondividing neuroblastoma cell line. Iran. Biomed. J. 2013, 17:171-178.
14. Habibi L., Shokrgozar M.A., Tabrizi M., Modaressi M.H., Akrami S.M. Mercury specifically induces LINE-1 activity in a human neuroblastoma cell line. Mutat. Res. 2013, 759:9-20.
15. Hedges D.J., Belancio V.P. Restless genomes humans as a model organism for understanding host-retrotransposable element dynamics. Adv. Genet. 2011, 73:219-262.
16. Ishizaka Y., Okudaira N., Tamura M., Iijima K., Shimura M., Goto M., Okamura T. Modes of retrotransposition of long interspersed element-1 by environmental factors. Front. Microbiol. 2012, 3:191.
17. Iskow R.C., McCabe M.T., Mills R.E., Torene S., Pittard W.S., Neuwald A.F., Van Meir E.G., Vertino P.M., Devine S.E. Natural mutagenesis of human genomes by endogenous retrotransposons. Cell 2010, 141:1253-1261.
18. Jarup L. Hazards of heavy metal contamination. Br. Med. Bull. 2003, 68:167-182.
19. Konkel M.K., Batzer M.A. A mobile threat to genome stability: the impact of non-LTR retrotransposons upon the human genome. Semin. Cancer Biol. 2010, 20:211-221.
20. Lau A.T., Li M., Xie R., He Q.Y., Chiu J.F. Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells. Carcinogenesis 2004, 25:21-28.
21. Lee E., Iskow R., Yang L., Gokcumen O., Haseley P., Luquette L.J., Lohr J.G., Harris C.C., Ding L., Wilson R.K., Wheeler D.A., Gibbs R.A., Kucherlapati R., Lee C., Kharchenko P.V., Park P.J. Landscape of somatic retrotransposition in human cancers. Science 2012, 337:967-971.
22. Liaw J., Marshall G., Yuan Y., Ferreccio C., Steinmaus C., Smith A.H. Increased childhood liver cancer mortality and arsenic in drinking water in northern Chile. Cancer Epidemiol. Biomarkers Prev. 2008, 17:1982-1987.
23. Liu J., Waalkes M.P. Liver is a target of arsenic carcinogenesis. Toxicol. Sci. 2008, 105:24-32.
24. Markopoulos G., Noutsopoulos D., Mantziou S., Vartholomatos G., Monokrousos N., Angelidis C., Tzavaras T. Arsenic induces VL30 retrotransposition: the involvement of oxidative stress and heat-shock protein 70. Toxicol. Sci. 2013, 134:312-322.
25. Miller W.H. Molecular targets of arsenic trioxide in malignant cells. Oncologist 2002, 7(Suppl. 1):14-19.
26. Mills R.E., Bennett E.A., Iskow R.C., Devine S.E. Which transposable elements are active in the human genome?. Trends Genet.: TIG 2007, 23:183-191.
27. Okudaira N., Iijima K., Koyama T., Minemoto Y., Kano S., Mimori A., Ishizaka Y. Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct. Proc. Natl. Acad. Sci. USA 2010, 107:18487-18492.
28. Okudaira N., Okamura T., Tamura M., Iijma K., Goto M., Matsunaga A., Ochiai M., Nakagama H., Kano S., Fujii-Kuriyama Y., Ishizaka Y. Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor. Oncogene 2013, 32:4903-4912.
29. Ostertag E.M., Prak E.T., DeBerardinis R.J., Moran J.V., Kazazian H.H. Determination of L1 retrotransposition kinetics in cultured cells. Nucl. Acids Res. 2000, 28:1418-1423.
30. Petit A., Delaune A., Falluel-Morel A., Goulle J.P., Vannier J.P., Dubus I., Vasse M. Importance of ERK activation in AsO-induced differentiation and promyelocytic leukemia nuclear bodies formation in neuroblastoma cells. Pharmacol. Res. 2013, 77c:11-21.
31. Rangwala S.H., Kazazian H.H. The L1 retrotransposition assay: a retrospective and toolkit. Methods 2009, 49:219-226.
32. Reichard J.F., Puga A. Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics 2010, 2:87-104.
33. Tse W.P., Cheng C.H., Che C.T., Lin Z.X. Arsenic trioxide, arsenic pentoxide, and arsenic iodide inhibit human keratinocyte proliferation through the induction of apoptosis. J. Pharmacol. Exp. Ther. 2008, 326:388-394.
34. Watanabe T., Ohta Y., Mizumura A., Kobayashi Y., Hirano S. Analysis of arsenic metabolites in HepG2 and AS3MT-transfected cells. Arch. Toxicol. 2011, 85:577-588.