Clinical significance of RKIP mRNA expression in non-small cell lung cancer

Tumor Biology

Volumn 35, Issue 5, 2014, Pages 4377-4380

  Wang, Qin ^a   Wu, Xiaodong ^b   Wu, Ting ^b   Li, Gui Mei ^c   Shi, Yi ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c No 81 Hospital of PLA   (China)

Author keywords

Non small cell lung cancers; Raf 1 kinase inhibitor protein; Real Time PCR

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PEBP1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER STAGING; CLINICAL FEATURE; DNA SYNTHESIS; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; RNA, MESSENGER;

EID: 84902997186     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-1575-4     Document Type: Article

References (14)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30.
2. Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83:584-94. (Pubitemid 351720831)
3. Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD. Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidencebased clinical practice guidelines. Chest. 2013;143(5 Suppl):e1S-e29S.
4. National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in Oncology: Non-Small Cell Lung Cancer, Version 2, 2013. http://www.nccn.org/ professionals/physician-gls/f-guidelines.asp#nscl
5. Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, et al. Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 2000;20:3079-85. (Pubitemid 30215020)
6. Granovsky AE, Rosner MR. Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor. Cell Res. 2008;18(4):452-7. (Pubitemid 351498852)
7. Beshir AB, Ren G, Magpusao AN, Barone LM,Yeung KC, Fenteany G. Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer Lett. 2010;299(2):137-49.
8. Zeng L, Imamoto A, Rosner MR. Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target. Expert Opin Ther Targets. 2008;12(10):1275-87. doi:10.1517/14728222.12.10.1275.
9. Fu Z, Smith PC, Zhang L, Rubin MA, Dunn RL, Yao Z, et al. Effects of Raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst. 2003;95(12):878-89. (Pubitemid 36833879)
10. Xu YF, Yi Y, Qiu SJ, Gao Q, Li YW, Dai CX, et al. PEBP1 downregulation is associated to poor prognosis in HCC related to hepatitis B infection. J Hepatol. 2010;53(5):872-9.
11. Lin K, Baritaki S, Militello L, Malaponte G, Bevelacqua Y, Bonavida B. The role of B-RAF mutations in melanoma and the induction of EMT via dysregulation of the NF-kappaB/Snail/RKIP/PTEN circuit. Genes Cancer. 2010;1(5):409-20.
12. Al-Mulla F, Hagan S, Al-Ali W, Jacob SP, Behbehani AI, Bitar MS, et al. Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability. J Clin Pathol. 2008;61(4):524-9. (Pubitemid 351518239)
13. Li HZ, Gao Y, Zhao XL, Liu YX, Sun BC, Yang J, et al. Effects of Raf kinase inhibitor protein expression onmetastasis and progression of human breast cancer. Mol Cancer Res. 2009;7(6):832-40.
14. Beach S, Tang H, Park S, Dhillon AS, Keller ET, Kolch W, et al. Snail is a repressor ofRKIP transcription inmetastatic prostate cancer cells. Oncogene. 2008;27(15):2243-8. (Pubitemid 351483382)