Targeting aurora kinase a inhibits hypoxia-mediated neuroblastoma cell tumorigenesis

Anticancer Research

Volumn 34, Issue 5, 2014, Pages 2269-2274

  Romain, Carmelle V ^a   Paul, Pritha ^a,b   Lee, Sora ^a,b   Qiao, Jingbo ^a   Chung, Dai H ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AURKA; Hypoxia; Neuroblastoma; Tumorigenesis

Indexed keywords

ALISERTIB; AURORA A KINASE; COBALT (II)CHLORIDE; COBALT CHLORIDE; FOCAL ADHESION KINASE; UNCLASSIFIED DRUG; AURKA PROTEIN, HUMAN;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; HYPOXIA; NEUROBLASTOMA CELL; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATORY MECHANISM; TUMOR GROWTH; UPREGULATION; AURKA; CELL HYPOXIA; CELL MOTION; GENETIC TRANSFECTION; IMMUNOBLOTTING; METABOLISM; NEUROBLASTOMA; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE;

AURKA; HYPOXIA; NEUROBLASTOMA; TUMORIGENESIS;

AURORA KINASE A; CARCINOGENESIS; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; IMMUNOBLOTTING; NEUROBLASTOMA; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSFECTION;

EID: 84902996793     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Casazza A, Di Conza G, Wenes M, Finisguerra V, Deschoemaeker S and Mazzone M: Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment. Oncogene 2013. This publication is an Epub ahead of print. There is no further information available as to its volume and page number.
2. Dungwa JV, Hunt LP, and Ramani P: Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas. Human pathology 43: 1651-1660, 2012.
3. Jogi A, Ora I, Nilsson H, Lindeheim A, Makino Y, Poellinger L, Axelson H and Pahlman S: Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crestlike phenotype. Proceedings of the National Academy of Sciences of the United States of America 99: 7021-7026, 2002.
4. Dungwa JV, Hunt LP and Ramani P: HIF-1alpha up-regulation is associated with adverse clinicopathological and biological factors in neuroblastomas. Histopathology 61: 417-427, 2012.
5. Shang X, Burlingame SM, Okcu MF, Ge N, Russell HV, Egler RA, David RD, Vasudevan SA, Yang J and Nuchtern JG: Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma. Molecular cancer therapeutics 8: 2461-2469, 2009.
6. Romain C, Paul P, Kim KW, Lee S, Qiao J and Chung DH: Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma. Journal of pediatric surgery 49: 159-165, 2014.
7. Klein A, Flugel D and Kietzmann T: Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1. Molecular biology of the cell 19: 3667-3675, 2008.
8. Xu J, Li H, Wang B, Xu Y, Yang J, Zhang X, Harten SK, Shukla D, Maxwell PH, Pei D and Esteban MA: VHL inactivation induces HEF1 and Aurora kinase A. Journal of the American Society of Nephrology: JASN 21: 2041-2046, 2010.
9. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW and Giaccia AJ: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379: 88-91, 1996.
10. Otto T, Horn S, Brockmann M, Eilers U, Schuttrumpf L, Popov N, Kenney AM, Schulte JH, Beijersbergen R, Christiansen H, Berwanger B and Eilers M: Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer cell 15: 67-78, 2009.
11. Teppo S, Sundquist E, Vered M, Holappa H, Parkkisenniemi J, Rinaldi T, Lehenkari P, Grenman R, Dayan D, Risteli J, Salo T and Nyberg P: The hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cells. Experimental cell research 319: 376-389, 2013.
12. Cox BD, Natarajan M, Stettner MR and Gladson CL: New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. Journal of cellular biochemistry 99: 35-52, 2006.
13. Owens LV, Xu L, Craven RJ, Dent GA, Weiner TM, Kornberg L, Liu ET and Cance WG: Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer research 55: 2752-2755, 1995.
14. Zhang H, Chen X, Liu B and Zhou L: Effects of stable knockdown of Aurora kinase A on proliferation, migration, chromosomal instability, and expression of focal adhesion kinase and matrix metalloproteinase-2 in HEp-2 cells. Molecular and cellular biochemistry 357: 95-106, 2011.
15. Lee S, Qiao J, Paul P, O'Connor KL, Evers MB and Chung DH: FAK is a critical regulator of neuroblastoma liver metastasis. Oncotarget 3: 1576-1587, 2012.
16. Dai Y, Bae K and Siemann DW: Impact of hypoxia on the metastatic potential of human prostate cancer cells. International journal of radiation oncology, biology, physics 81: 521-528, 2011.
17. Hanna SC, Krishnan B, Bailey ST, Moschos SJ, Kuan PF, Shimamura T, Osborne LD, Siegel MB, Duncan LM, O'Brien ET, 3rd, Superfine R, Miller CR, Simon MC, Wong KK and Kim WY: HIF1alpha and HIF2alpha independently activate SRC to promote melanoma metastases. The Journal of clinical investigation 123: 2078-2093, 2013.
18. Guadamillas MC, Cerezo A, and Del Pozo MA: Overcoming anoikis-pathways to anchorage-independent growth in cancer. Journal of cell science 124: 3189-3197, 2011.
19. Li S and Hua ZC: FAK expression regulation and therapeutic potential. Advances in cancer research 101: 45-61, 2008.
20. Lee SH, Lee YJ, Song CH, Ahn YK and Han HJ: Role of FAK phosphorylation in hypoxia-induced hMSCS migration: involvement of VEGF as well as MAPKS and eNOS pathways. American journal of physiology Cell physiology 298: C847-856, 2010.
21. Lee SH, Lee YJ and Han HJ: Role of hypoxia-induced fibronectin-integrin beta1 expression in embryonic stem cell proliferation and migration: Involvement of PI3K/Akt and FAK. Journal of cellular physiology 226: 484-493, 2011.
22. Dar AA, Goff LW, Majid S, Berlin J and El-Rifai W: Aurora kinase inhibitors-rising stars in cancer therapeutics? Molecular cancer therapeutics 9: 268-278, 2010.