The proliferation arrest of primary tumor cells out-of-niche is associated with widespread downregulation of mitotic and transcriptional genes

Hematology

Volumn 19, Issue 5, 2014, Pages 286-292

  Cohen, Yossi ^a   Gutwein, Odit ^a   Garach Jehoshua, Osnat ^a   Bar Haim, Adina ^a   Kornberg, Abraham ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Gene expression profile; IL8; Leukemia; Myeloma; Niche; SPP1

Indexed keywords

ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CASE REPORT; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS RATE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RNA EXTRACTION; TRANSCRIPTION INITIATION; TUMOR CELL; TUMOR MICROENVIRONMENT; BIOLOGY; BONE MARROW; CELL CYCLE CHECKPOINT; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MITOSIS; MOLECULAR GENETICS; MULTIPLE MYELOMA; NEOPLASM; PATHOLOGY;

BONE MARROW; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOSIS; MOLECULAR SEQUENCE ANNOTATION; MULTIPLE MYELOMA; NEOPLASMS;

EID: 84902837005     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1179/1607845413Y.0000000125     Document Type: Article

References (10)

1. Cohen Y, Garach-Jehoshua O, Bar-Chaim A, Kornberg A. Niche-modulated and niche-modulating genes in bone marrow cells. Blood Cancer J. 2012;14(2):e97.
2. Haylock DN, Nilsson SK. Osteopontin: a bridge between bone and blood. Br J Haematol. 2006;134:467-74.
3. Berger S, Dyugovskaya L, Polyakov A, Lavie L. Short-term fibronectin treatment induces endothelial-like and angiogenic properties in monocyte-derived immature dendritic cells: involvement of intracellular VEGF and MAPK regulation. Eur J Cell Biol. 2012;91:640-53.
4. Kline M, Donovan K, Wellik L, Lust C, Jin W, Moon-Tasson L, et al. Cytokine and chemokine profiles in multiple myeloma: significance of stromal interaction and correlation of IL-8 production with disease progression. Leuk Res. 2007;31:591-8.
5. Crouser ED, Culver DA, Knox KS, Julian MW, Shao G, Abraham S, et al. Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis. Am J Respir Crit Care Med. 2009;179: 929-38.
6. Caserman S, Lah TT. Comparison of expression of cathepsins B and L and MMP2 in endothelial cells and in capillary sprouting in collagen gel. Int J Biol Markers 2004;19:120-9.
7. McMellen ME, Wakeman D, Erwin CR, Guo J, Warner BW. Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection. Surgery 2010;148:364-70.
8. Liu Q, Li G, Li R, Shen J, He Q, Deng L, et al. IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines. J Neurooncol. 2010;100:165-76.
9. Bowcock H, Dickson RW. Mitotic leukoblasts in the peripheral blood of a case of acute leukemia. Ann Intern Med. 1931;4: 1344-6.
10. Matsuoka A, Tochigi A, Kishimoto M, Nakahara T, Kondo T, Tsujioka T, et al. Lenalidomide induces cell death in an MDSderived cell line with deletion of chromosome 5q by inhibition of cytokinesis. Leukemia 2010;24:748-55.